Twinning for Promoting Excellence, Ability and Knowledge to develop novel approaches for targeting inflammatory and degenerative age-related joint diseases

Informazioni relative al progetto

TWINFLAG

ID dell’accordo di sovvenzione: 101079489

DOI

10.3030/101079489

Progetto chiuso

Data della firma CE 12 Agosto 2022

Data di avvio 1 Gennaio 2023

Data di completamento 30 Giugno 2026

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Lithuania

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Plan for dissemination and exploitation activities

A plan for dissemination and exploitation including communication activities

Data Management Plan (1)

Data Management Plan

Data Management plan will be prepared (M6) and updated during the project.

Pubblicazioni

Peer reviewed articles (13)

Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format

Autori: Ursule Kalvaityte, Edvardas Bagdonas, Gailute Kirdaite, Asta Kausaite-Minkstimiene, Ilona Uzieliene, Almira Ramanaviciene, Anton Popov, Greta Butkiene, Vitalijus Karabanovas, Jaroslav Denkovskij, Ali Mobasheri, Eiva Bernotiene
Pubblicato in: International Journal of Nanomedicine, Numero Volume 20, 2025, ISSN 1178-2013
Editore: Informa UK Limited
DOI: 10.2147/IJN.S477118

Identification of Bone Marrow and Peripheral Blood Plasma Extracellular Vesicle Protein Biomarker Signatures for Multiple Myeloma Diagnosis and Staging

Autori: Angelique Cheryl, Rebecca Sheridan, Kieran Brennan, Despina Bazou, David Matallanas, Peter O'Gorman, Luis F Iglesias-Martinez, Margaret M Mc Gee
Pubblicato in: International Journal of Nanomedicine, Numero Volume 21, 2026, ISSN 1178-2013
Editore: Informa UK Limited
DOI: 10.2147/IJN.S576858

Effect of HIF-1α inhibitor LW6 on chondrogenic properties of mesenchymal stromal cells and chondrocytes in cell sheets under physioxia

Autori: Ignas Lebedis, Jolita Pachaleva, Eiva Bernotiene, Daiva Bironaite, Tomas Ragauskas, Giedrius Kvedaras, Gunaras Terbetas, Ilona Uzieliene
Pubblicato in: Journal of Biological Engineering, Numero 20, 2026, ISSN 1754-1611
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13036-025-00588-8

Potential of MSCA1 for isolating osteogenic cells in a chondrocyte population

Autori: Ausra Unguryte, Ilona Uzieliene, Edvardas Bagdonas, Aiste Zentelyte, Narūnas Porvaneckas, Eiva Bernotiene
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-91303-6

The Effect of TGF-β3 and IL-1β on L-Type Voltage-Operated Calcium Channels and Calcium Ion Homeostasis in Osteoarthritic Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells During Chondrogenesis

Autori: Anastasiia Shelest, Aidas Alaburda, Raminta Vaiciuleviciute, Ilona Uzieliene, Paulina Bialaglovyte, Eiva Bernotiene
Pubblicato in: Pharmaceutics, Numero 17, 2025, ISSN 1999-4923
Editore: MDPI AG
DOI: 10.3390/PHARMACEUTICS17030343

Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration

Autori: Md.F. Kulyar, Jolita Pachaleva, Sandra Brazaite, Muhammad Akhtar, Mohammad Mehedi Hasan, Saeed Kaboli, Ignas Lebedis, Eiva Bernotiene
Pubblicato in: Journal of Orthopaedic Translation, Numero 60, 2026, ISSN 2214-031X
Editore: Elsevier BV
DOI: 10.1016/J.JOT.2026.101178

Modeling the Effect of Annulus Fibrosus Stiffness on the Stressed State of a Vertebral L1 Body and Nucleus Pulposus

Autori: Oleg Ardatov, Jolita Pachaleva, Viktorija Aleksiuk, Algirdas Maknickas, Ilona Uzieliene, Raminta Vaiciuleviciute, Eiva Bernotiene
Pubblicato in: Bioengineering, Numero 11, 2025, ISSN 2306-5354
Editore: MDPI AG
DOI: 10.3390/BIOENGINEERING11040305

Electrical Stimulation in Cartilage Tissue Engineering

Autori: Raminta Vaiciuleviciute, Ilona Uzieliene, Paulius Bernotas, Vitalij Novickij, Aidas Alaburda, Eiva Bernotiene
Pubblicato in: Bioengineering, Numero 10, 2025, ISSN 2306-5354
Editore: MDPI AG
DOI: 10.3390/BIOENGINEERING10040454

Extracellular vesicles in the heart: mediators of intercellular communication in health and disease in vitro

Autori: Raminta Vaiciuleviciute, Mario Schubert, Kaomei Guan, Eiva Bernotiene
Pubblicato in: Cell Communication and Signaling, Numero 24, 2026, ISSN 1478-811X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12964-026-02866-4

Clinical Applications of Extracellular Vesicles: Promises and Pitfalls

Autori: Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Pubblicato in: International Journal of Molecular Sciences, Numero 27, 2026, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS27031509

The Challenges of Local Intra-Articular Therapy

Autori: Gailute Kirdaite, Jaroslav Denkovskij, Diana Mieliauskaite, Jolita Pachaleva, Eiva Bernotiene
Pubblicato in: Medicina, Numero 60, 2025, ISSN 1648-9144
Editore: MDPI AG
DOI: 10.3390/MEDICINA60111819

Identification of Extracellular Vesicle Signatures of Daratumumab Treated Multiple Myeloma

Autori: Kieran Brennan, Katrine F. Iversen, Alfonso Blanco‐Fernández, Thomas Lund, Torben Plesner, Margaret M. Mc Gee
Pubblicato in: Journal of Extracellular Vesicles, Numero 15, 2026, ISSN 2001-3078
Editore: Wiley
DOI: 10.1002/JEV2.70213

Therapeutic Potential of Extracellular Vesicles: From Biogenesis, Isolation and Molecular Characterization to Addressing Translational Gaps and Regulatory Barriers

Autori: Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Pubblicato in: International Journal of Molecular Sciences, Numero 27, 2026, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS27041676

Other (1)

Advancing Nano-Flow Cytometry: High-Precision Sorting and Analysis of Extracellular Vesicles

Autori: Irene Castrosín, Vanessa Costa, Brandy Pickney, Ionita Ghiran, Kieran Brennan, Flor Delgado, César Reyes-Pérez, K Jensen, Alfonso Blanco, John Tigges, Margaret Mc Gee
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.64898/2026.07.27.741001