Twinning for Promoting Excellence, Ability and Knowledge to develop novel approaches for targeting inflammatory and degenerative age-related joint diseases

Project Information

TWINFLAG

Grant agreement ID: 101079489

DOI

10.3030/101079489

Project closed

EC signature date 12 August 2022

Start date 1 January 2023

End date 30 June 2026

Funded under

• Widening participation and spreading excellence

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Lithuania

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Plan for dissemination and exploitation activities

A plan for dissemination and exploitation including communication activities

Data Management Plan (1)

Data Management Plan

Data Management plan will be prepared (M6) and updated during the project.

Publications

Peer reviewed articles (13)

Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format

Author(s): Ursule Kalvaityte, Edvardas Bagdonas, Gailute Kirdaite, Asta Kausaite-Minkstimiene, Ilona Uzieliene, Almira Ramanaviciene, Anton Popov, Greta Butkiene, Vitalijus Karabanovas, Jaroslav Denkovskij, Ali Mobasheri, Eiva Bernotiene
Published in: International Journal of Nanomedicine, Issue Volume 20, 2025, ISSN 1178-2013
Publisher: Informa UK Limited
DOI: 10.2147/IJN.S477118

Identification of Bone Marrow and Peripheral Blood Plasma Extracellular Vesicle Protein Biomarker Signatures for Multiple Myeloma Diagnosis and Staging

Author(s): Angelique Cheryl, Rebecca Sheridan, Kieran Brennan, Despina Bazou, David Matallanas, Peter O'Gorman, Luis F Iglesias-Martinez, Margaret M Mc Gee
Published in: International Journal of Nanomedicine, Issue Volume 21, 2026, ISSN 1178-2013
Publisher: Informa UK Limited
DOI: 10.2147/IJN.S576858

Effect of HIF-1α inhibitor LW6 on chondrogenic properties of mesenchymal stromal cells and chondrocytes in cell sheets under physioxia

Author(s): Ignas Lebedis, Jolita Pachaleva, Eiva Bernotiene, Daiva Bironaite, Tomas Ragauskas, Giedrius Kvedaras, Gunaras Terbetas, Ilona Uzieliene
Published in: Journal of Biological Engineering, Issue 20, 2026, ISSN 1754-1611
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13036-025-00588-8

Potential of MSCA1 for isolating osteogenic cells in a chondrocyte population

Author(s): Ausra Unguryte, Ilona Uzieliene, Edvardas Bagdonas, Aiste Zentelyte, Narūnas Porvaneckas, Eiva Bernotiene
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-91303-6

The Effect of TGF-β3 and IL-1β on L-Type Voltage-Operated Calcium Channels and Calcium Ion Homeostasis in Osteoarthritic Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells During Chondrogenesis

Author(s): Anastasiia Shelest, Aidas Alaburda, Raminta Vaiciuleviciute, Ilona Uzieliene, Paulina Bialaglovyte, Eiva Bernotiene
Published in: Pharmaceutics, Issue 17, 2025, ISSN 1999-4923
Publisher: MDPI AG
DOI: 10.3390/PHARMACEUTICS17030343

Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration

Author(s): Md.F. Kulyar, Jolita Pachaleva, Sandra Brazaite, Muhammad Akhtar, Mohammad Mehedi Hasan, Saeed Kaboli, Ignas Lebedis, Eiva Bernotiene
Published in: Journal of Orthopaedic Translation, Issue 60, 2026, ISSN 2214-031X
Publisher: Elsevier BV
DOI: 10.1016/J.JOT.2026.101178

Modeling the Effect of Annulus Fibrosus Stiffness on the Stressed State of a Vertebral L1 Body and Nucleus Pulposus

Author(s): Oleg Ardatov, Jolita Pachaleva, Viktorija Aleksiuk, Algirdas Maknickas, Ilona Uzieliene, Raminta Vaiciuleviciute, Eiva Bernotiene
Published in: Bioengineering, Issue 11, 2025, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/BIOENGINEERING11040305

Electrical Stimulation in Cartilage Tissue Engineering

Author(s): Raminta Vaiciuleviciute, Ilona Uzieliene, Paulius Bernotas, Vitalij Novickij, Aidas Alaburda, Eiva Bernotiene
Published in: Bioengineering, Issue 10, 2025, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/BIOENGINEERING10040454

Extracellular vesicles in the heart: mediators of intercellular communication in health and disease in vitro

Author(s): Raminta Vaiciuleviciute, Mario Schubert, Kaomei Guan, Eiva Bernotiene
Published in: Cell Communication and Signaling, Issue 24, 2026, ISSN 1478-811X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12964-026-02866-4

Clinical Applications of Extracellular Vesicles: Promises and Pitfalls

Author(s): Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Published in: International Journal of Molecular Sciences, Issue 27, 2026, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS27031509

The Challenges of Local Intra-Articular Therapy

Author(s): Gailute Kirdaite, Jaroslav Denkovskij, Diana Mieliauskaite, Jolita Pachaleva, Eiva Bernotiene
Published in: Medicina, Issue 60, 2025, ISSN 1648-9144
Publisher: MDPI AG
DOI: 10.3390/MEDICINA60111819

Identification of Extracellular Vesicle Signatures of Daratumumab Treated Multiple Myeloma

Author(s): Kieran Brennan, Katrine F. Iversen, Alfonso Blanco‐Fernández, Thomas Lund, Torben Plesner, Margaret M. Mc Gee
Published in: Journal of Extracellular Vesicles, Issue 15, 2026, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/JEV2.70213

Therapeutic Potential of Extracellular Vesicles: From Biogenesis, Isolation and Molecular Characterization to Addressing Translational Gaps and Regulatory Barriers

Author(s): Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Published in: International Journal of Molecular Sciences, Issue 27, 2026, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS27041676

Other (1)

Advancing Nano-Flow Cytometry: High-Precision Sorting and Analysis of Extracellular Vesicles

Author(s): Irene Castrosín, Vanessa Costa, Brandy Pickney, Ionita Ghiran, Kieran Brennan, Flor Delgado, César Reyes-Pérez, K Jensen, Alfonso Blanco, John Tigges, Margaret Mc Gee
Published in: 2026
Publisher: openRxiv
DOI: 10.64898/2026.07.27.741001