Preventing lifetime obesity by early risk-factor identification, prognosis and intervention

Project Information

eprObes

Grant agreement ID: 101080219

DOI

10.3030/101080219

EC signature date 11 April 2023

Start date 1 May 2023

End date 30 April 2028

Funded under

• Health

Total cost

€ 9 875 071,25

EU contribution

€ 9 875 071,25

Coordinated by

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

D/C/E Plan of eprObes

Generation of Dissemination, Communication & Exploita-tion (D/C/E) Plan for eprObes

Websites, patent fillings, videos etc. (2)

Project website & Observatory

Development of eprObes website, incl. a repository of all the result (Observatory)

Project Handbook

Development of eprObes handbook

Publications

Peer reviewed articles (37)

Multiomics and eXplainable artificial intelligence for decision support in insulin resistance early diagnosis: A pediatric population-based longitudinal study

Author(s): Álvaro Torres-Martos, Augusto Anguita-Ruiz, Mireia Bustos-Aibar, Alberto Ramírez-Mena, María Arteaga, Gloria Bueno, Rosaura Leis, Concepción M. Aguilera, Rafael Alcalá, Jesús Alcalá-Fdez
Published in: Artificial Intelligence in Medicine, Issue 156, 2024, ISSN 0933-3657
Publisher: Elsevier BV
DOI: 10.1016/j.artmed.2024.102962

Probiotic and prebiotic interventions in eating disorders: A narrative review

Author(s): Isabel Baenas, Lucía Camacho‐Barcia, Romina Miranda‐Olivos, Neus Solé‐Morata, Alejandra Misiolek, Susana Jiménez‐Murcia, Fernando Fernández‐Aranda
Published in: European Eating Disorders Review, Issue 32, 2024, ISSN 1072-4133
Publisher: Wiley
DOI: 10.1002/erv.3069

The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin

Author(s): María S. Avendaño, Cecilia Perdices-Lopez, Yolanda Guerrero-Ruiz, Francisco Ruiz-Pino, Ana B. Rodriguez-Sanchez, María J. Sanchez-Tapia, Verónica Sobrino, Rafael Pineda, Alexia Barroso, Alejandro Correa-Sáez, Maribel Lara-Chica, José C. Fernandez-Garcia, Ana B. García-Redondo, Raquel Hernanz, Miguel Ruiz-Cruz, David Garcia-Galiano, Nelly Pitteloud, Marco A. Calzado, Ana M. Briones, María J. Vázquez, Manuel Tena-Sempere
Published in: Metabolism, Issue 157, 2024, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.155932

Kisspeptins centrally modulate food intake and locomotor activity in mice independently of gonadal steroids in a sexually dimorphic manner

Author(s): Inmaculada Velasco; Silvia DazaDueas; Encarnacin Torres; Francisco RuizPino; Mara J. Vzquez; Manuel TenaSempere
Published in: Journal of Neuroendocrinology, 2024, ISSN 1365-2826
Publisher: Wiley
DOI: 10.1111/jne.13433

<scp>STING</scp> inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis

Author(s): Vanessa Marchant, Jorge García‐Giménez, Guadalupe T González‐Mateo, Pilar Sandoval, Lucía Tejedor‐Santamaria, Sandra Rayego‐Mateos, Ricardo Ramos, José A Jiménez‐Heffernan, Alberto Ortiz, Anne‐Catherine Raby, Manuel López‐Cabrera, Adrián M Ramos, Marta Ruiz‐Ortega
Published in: The Journal of Pathology, Issue 267, 2025, ISSN 0022-3417
Publisher: Wiley
DOI: 10.1002/PATH.6462

Serum DLK1 During Minipuberty and Pubertal Transition in Healthy Girls and in Girls With Precocious Puberty

Author(s): Lea Vilmann, Kaspar Sørensen, Alexander S Busch, Marie L Ljubicic, Emmie N Upners, Margit B Fischer, Trine H Johannsen, Stine A Holmboe, Anders Juul, Casper P Hagen
Published in: The Journal of Clinical Endocrinology &amp; Metabolism, 2024, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgae762

Determinants of Parents' and Adolescents' Motivation Before Pediatric Weight Management—Data From the <scp>STARKIDS</scp> Cohort

Author(s): Anne Herschbach, Rebecca Erschens, Florian Junne, Stefan Ehehalt, Johann Jacoby, Peter Martus, Isabelle Mack, Alisa Weiland, Inga Krauß, Constanze Greule, Guido Zurstiege, Annalena Wels, Sophia Helen Adam, Andreas Hoell, Wolfgang Bethge, Monika Ums, Torben Sammet, Maren Reyer, Olaf Schliesing, Stephan Zipfel, Caterina Gawrilow, Katrin Elisabeth Giel, Katrin Ziser
Published in: Obesity, 2026, ISSN 1930-7381
Publisher: Wiley
DOI: 10.1002/OBY.70185

Hypothalamic obesity: from basic mechanisms to clinical perspectives

Author(s): Jesús Argente, I Sadaf Farooqi, Julie A Chowen, Peter Kühnen, Miguel López, Eugenia Morselli, Hoong-Wei Gan, Helen A Spoudeas, Martin Wabitsch, Manuel Tena-Sempere
Published in: The Lancet Diabetes &amp; Endocrinology, Issue 13, 2026, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/S2213-8587(24)00283-3

Longitudinal dynamics of impulsivity in individuals undergoing obesity surgery – a systematic review

Author(s): Katrin Elisabeth Giel, Lucia Camacho-Barcia, Laura Schultze-Rhonhof, Fernando Fernandez-Aranda, Stephan Zipfel, Kathrin Schag
Published in: Reviews in Endocrine and Metabolic Disorders, 2025, ISSN 1389-9155
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11154-025-10000-X

Predictors of Body Weight Loss and Body Weight Loss Maintenance in Children and Adolescents following Inpatient Multidisciplinary Obesity Treatment

Author(s): Weiland, Alisa; Kasemann, Lena; Sauer, Helene; Horing, Björn; Zipfel, Stephan; Mazurak, Nazar; Enck, Paul; Mack, Isabelle
Published in: Obesity Facts, ISSN 1662-4033
Publisher: S. Karger AG
DOI: 10.1159/000548602

Cluster analysis in gambling disorder based on sociodemographic, neuropsychological, and neuroendocrine features regulating energy homeostasis

Author(s): Baenas, Isabel; Mora Maltas, Bernat; Etxandi, Mikel; Lucas, Ignacio; Granero, Roser; Fernndez Aranda, Fernando; Tovar, Sulay; Sol Morata, Neus; Gmez Pea, Mnica; Moragas, Laura; Del Pino Gutirrez, Amparo; Tapia, Javier; Diguez, Carlos; Goudriaan, Anna E.; Jimnez-Murcia, Susana
Published in: Comprehensive Psychiatry, 2024, ISSN 0000-0000
Publisher: DOAJ
DOI: 10.1016/j.comppsych.2023.152435

Beyond M1/M2: The role of reactive oxygen species in liver fibrosis and immune modulation

Author(s): Huilun Lu, Jie Huang, Ya-chao Wang, Eudald Casals, Gregori Casals, Muling Zeng
Published in: Redox Biology, Issue 88, 2026, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/J.REDOX.2025.103933

OBEClust: joining forces to prevent obesity

Author(s): Manuel Tena-Sempere, Dimitrios-Dionyssios Koutsouris, George Dedoussis, Jeroen Lakerveld, Karl-Heinz Wagner, Itziar Tueros, Philippe Froguel, Torsten Bohn, Paulo J. Oliveira
Published in: Nature Reviews Endocrinology, Issue 22, 2026, ISSN 1759-5029
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01212-X

Rethinking cutoff values for the South Oaks Gambling Screen: Sex-specific insights and DSM-5 severity adjustments in Gambling Disorder assessment

Author(s): Ignacio Lucas, Roser Granero, Bernat Mora-Maltas, Fernando Fernández-Aranda, Susana Jiménez-Murcia
Published in: Journal of Behavioral Addictions, Issue 13, 2024, ISSN 2062-5871
Publisher: Akademiai Kiado Zrt.
DOI: 10.1556/2006.2024.00053

Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions

Author(s): Valeria Kopytina, Vanessa Marchant, Raquel Rodrigues-Diez, Lucía Pascual-Antón, Nora Toggweiler, Lisa Strahl, Jamie Kane, Antonio Tejera-Muñoz, Marcelino Cortés, David Sucunza, Juan J Vaquero, Marc Vervloet, Dorothea Piecha, Etto C Eringa, Marta Ruiz-Ortega, Manuel López-Cabrera, Guadalupe T González-Mateo
Published in: Nephrology Dialysis Transplantation, 2025, ISSN 0931-0509
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NDT/GFAF249

Biofeedback Interventions for Impulsivity-related Processes in Addictive Disorders

Author(s): Ignacio Lucas; Neus Sol-Morata; Isabel Baenas; Magda Rosinska; Fernando Fernndez-Aranda; Susana Jimnez-Murcia
Published in: Current Addiction Reports, 2023, ISSN 2196-2952
Publisher: Springer Nature
DOI: 10.1007/s40429-023-00499-y

International Journal of Molecular Sciences

Author(s): Jose Bellver; Marta Gonzalez-Monfort; Sandra González; Bruno Toson; Elena Labarta; Gemma Castillón; Giulia Mariani; Carmina Vidal; Juan Giles; Fabio Cruz; Agustin Ballesteros; Marcos Ferrando; Juan Antonio García-Velasco; Diana Valbuena; Felipe Vilella; Marcos Parras-Molto; Esther Tercero-Atencia; Carlos Simon; Inmaculada Moreno
Published in: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Publisher: International journal of molecular sciences (Online)
DOI: 10.3390/IJMS252312600

Nutrients

Author(s): Lucía Camacho-Barcia; Isabel Sánchez; Ana Ibáñez-Caparrós; Noriaki Ohsako; Roser Granero; Cristina Artero; José Manuel Crespo; Georgios Paslakis; Susana Jiménez-Murcia; Fernando Fernández-Aranda
Published in: Nutrients, 2024, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/NU16142337

Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity

Author(s): Elvira Rodríguez-Vázquez, Álvaro Aranda-Torrecillas, María López-Sancho, Manuel Jiménez-Puyer, Silvia Daza-Dueñas, Alexia Barroso, Verónica Sobrino, Francisco Gaytan, Elia Obis, Juan M. Castellano, Manuel Tena-Sempere
Published in: American Journal of Physiology-Endocrinology and Metabolism, Issue 328, 2025, ISSN 0193-1849
Publisher: American Physiological Society
DOI: 10.1152/AJPENDO.00493.2024

Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

Author(s): I. Baenas; L. Camacho-Barcia; R. Granero; C. Razquin; D. Corella; C. Gmez-Martnez; O. Castaer-Nio; J. A. Martnez; . M. Alonso-Gmez; J. Wrnberg; J. Vioque; D. Romaguera; J. Lpez-Miranda; R. Estruch; F. J. Tinahones; J. Lapetra; J. L. Serra-Majem; N. Cano-Ibez; J. A. Tur; V. Martn-Snchez; X. Pint; J. J. Gaforio; P. Mata-Martn; J. Vidal; C. Vzquez; L. Daimiel; E. Ros; S. Jimnez-Murcia; S. Dalsgaard; A. Garcia-Arellano; N. Babio; J. V. Sorli; C. Lassale; M. Garca-de-la-Hera; E. Gmez-Garca; M. A. Zulet; J. Konieczna; S. Martn-Pelez; L. Tojal-Sierra; F. J. Basterra-Gortari; S. de las Heras-Delgado; O. Portoles; M. . Muoz-Prez; A. P. Arenas-Larriva; L. Compa-Gabucio; S. Eguaras; S. Shyam; M. Fit; R. M. Baos; J. Salas-Salvad; F. Fernndez-Aranda
Published in: Journal of Endocrinological Investigation, 2024, ISSN 0000-0000
Publisher: Scopus 20
DOI: 10.1007/s40618-023-02278-y

Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives

Author(s): Lucia Camacho-Barcia, Katrin Elisabeth Giel, Susana Jiménez-Murcia, Julio Álvarez Pitti, Nadia Micali, Ignacio Lucas, Romina Miranda-Olivos, Lucero Munguia, Manuel Tena-Sempere, Stephan Zipfel, Fernando Fernández-Aranda
Published in: Trends in Molecular Medicine, Issue 30, 2024, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2024.02.007

Higher peak height velocity in early maturing girls depends on insulin rather than fat mass or IGF-I

Author(s): Kaspar Sørensen, Casper P Hagen, Anders Juul
Published in: European Journal of Endocrinology, Issue 191, 2024, ISSN 0804-4643
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EJENDO/LVAE115

Independent effect of body fat content on inflammatory biomarkers in children and adolescents: The GENOBOX study

Author(s): Estela Skapino, Laura Gonzalez-Gayan, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Ma Teresa Llorente-Cereza, Rosaura Leis, Concepción M. Aguilera, Mercedes Gil-Campos, Luis A. Moreno, Gloria Bueno-Lozano
Published in: Nutrition, Metabolism and Cardiovascular Diseases, Issue 35, 2026, ISSN 0939-4753
Publisher: Elsevier BV
DOI: 10.1016/J.NUMECD.2024.103811

Hypothalamic SIRT1-mediated regulation of the hormonal trigger of ovulation and its repression in energy deficit

Author(s): María J. Vazquez, Silvia Daza-Dueñas, Inmaculada Velasco, Francisco Ruiz-Pino, María J. Sanchez-Tapia, María Manfredi-Lozano, Carmen Torres-Granados, Alexia Barroso, Juan Roa, Miguel A. Sánchez-Garrido, Carlos Dieguez, Alejandro Lomniczi, Rubén Nogueiras, Manuel Tena-Sempere
Published in: Metabolism, Issue 164, 2026, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/J.METABOL.2024.156125

The role of motivation in weight reduction programs for children and adolescents with overweight or obesity: a systematic review

Author(s): Herschbach, Anne; Wels, Annalena; Dieckmann, Pauline; Erschens, Rebecca; Junne, Florian; Ehehalt, Stefan; Zipfel, Stephan; Giel, Katrin Elisabeth; Ziser, Katrin
Published in: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2025, ISSN 1590-1262
Publisher: Springer Nature
DOI: 10.1007/S40519-025-01763-Y

Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

Author(s): Isabel Baenas; Romina Miranda-Olivos; Roser Granero; Neus Sol-Morata; Isabel Snchez; Antoni Pastor; Amparo del Pino-Gutirrez; Ester Codina; Francisco J. Tinahones; Jos A. Fernndez-Formoso; Nria Vilarrasa; Fernando Guerrero-Prez; Rafael Lopez-Urdiales; Nria Virgili; Carles Soriano-Mas; Susana Jimnez-Murcia; Rafael de la Torre; Fernando Fernndez-Aranda
Published in: European Psychiatry, 2023, ISSN 0000-0000
Publisher: Cambridge University Press
DOI: 10.1192/j.eurpsy.2023.2411

Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation

Author(s): Manuel Jimenez-Puyer, Verónica Sobrino, William H. Colledge, Susan Jones, Manuel Tena-Sempere
Published in: Reviews in Endocrine and Metabolic Disorders, 2025, ISSN 1389-9155
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11154-025-10001-W

Precocious Puberty and Risk of Psychiatric Disorders: A Nationwide Cohort Study Using Prospective Registry Data

Author(s): Trine Koch Hueg, Youn-Hee Lim, Stine Agergaard Holmboe, Nadia Micali, Anders Juul
Published in: The Journal of Clinical Endocrinology &amp; Metabolism, Issue 111, 2026, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/CLINEM/DGAF567

Journal of Behavioral Addictions

Author(s): Mikel Etxandi; Isabel Baenas; Bernat Mora-Maltas; Roser Granero; Fernando Fernández-Aranda; Sulay Tovar; Neus Solé-Morata; Ignacio Lucas; Sabela Casado; Mónica Gómez-Peña; Laura Moragas; Amparo del Pino-Gutiérrez; Javier Tapia; Eduardo Valenciano-Mendoza; Marc N. Potenza; Ashley N. Gearhardt; Carlos Diéguez; Susana Jiménez-Murcia
Published in: Journal of Behavioral Addictions, 2023, ISSN 2062-5871
Publisher: Akademiai Kiado
DOI: 10.1556/2006.2023.00051

Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlate in gambling disorder

Author(s): Isabel Baenas; Neus Sol-Morata; Roser Granero; Fernando Fernndez-Aranda; Mitona Pujadas; Bernat Mora-Maltas; Ignacio Lucas; Mnica Gmez-Pea; Laura Moragas; Amparo del Pino-Gutirrez; Javier Tapia; Rafael de la Torre; Marc N. Potenza; Susana Jimnez-Murcia
Published in: European Psychiatry, 2023, ISSN 0000-0000
Publisher: Cambridge University Press
DOI: 10.1192/j.eurpsy.2023.2460

Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

Author(s): Romina Miranda-Olivos; Isabel Baenas; Trevor Steward; Roser Granero; ANTONI PASTOR; Isabel Snchez; Asier Juaneda; Amparo Del Pino; Jose A. Fernndez-Formoso; Nuria Vilarrasa; Fernando Guerrero-Prez; Nuria Virgili; Rafael Lpez-Urdiales; Susana Jimnez-Murcia; Rafael de la Torre; Carles Soriano-Mas; Fernando Fernandez-Aranda
Published in: Molecular Psychiatry, 2023, ISSN 0000-0000
Publisher: Dipòsit Digital de la Universitat de Barcelona
DOI: 10.21203/rs.3.rs-3008676/v1

The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity

Author(s): Edyta Łuszczki, Justyna Wyszyńska, Agnieszka Dymek, Dorota Drożdż, Laura González-Ramos, Isa Hartgring, Nuria García-Carbonell, Artur Mazur, Serap Erdine, Justė Parnarauskienė, Julio Alvarez-Pitti
Published in: Metabolites, Issue 14, 2024, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14120655

Multiomics and eXplainable artificial intelligence for decision support in insulin resistance early diagnosis: A pediatric population-based longitudinal study

Author(s): Álvaro Torres-Martos, Augusto Anguita-Ruiz, Mireia Bustos-Aibar, Alberto Ramírez-Mena, María Arteaga, Gloria Bueno, Rosaura Leis, Concepción M. Aguilera, Rafael Alcalá, Jesús Alcalá-Fdez
Published in: Artificial Intelligence in Medicine, Issue 156, 2024, ISSN 0933-3657
Publisher: Elsevier BV
DOI: 10.1016/J.ARTMED.2024.102962

Endocrine nanozymology: Nanozyme applications in diabetes, obesity, and hormonal disorders

Author(s): Huilun Lu, Zizhong Liu, Ya-chao Wang, Eudald Casals, Felicia A Hanzu, Manuel Morales-Ruiz, Muling Zeng, Gregori Casals
Published in: Theranostics, Issue 16, 2025, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/THNO.122577

Biomarker and clinical data–based predictor tool (MAUXI) for ultrafiltration failure and cardiovascular outcome in peritoneal dialysis patients: a retrospective and longitudinal study

Author(s): Eva María Arriero-País, María Auxiliadora Bajo-Rubio, Roberto Arrojo-García, Pilar Sandoval, Guadalupe Tirma González-Mateo, Patricia Albar-Vizcaíno, Gloria del Peso-Gilsanz, Marta Ossorio-González, Pedro Majano, Manuel López-Cabrera
Published in: BMJ Health &amp; Care Informatics, Issue 32, 2026, ISSN 2632-1009
Publisher: BMJ
DOI: 10.1136/BMJHCI-2024-101138

Applying psycho-behavioural phenotyping in obesity characterization

Author(s): Luca Camacho-Barcia; Ignacio Lucas; Romina Miranda-Olivos; Susana Jimnez-Murcia; Fernando Fernndez-Aranda
Published in: Reviews in Endocrine and Metabolic Disorders, 2023, ISSN 1573-2606
Publisher: Springer Nature
DOI: 10.1007/s11154-023-09810-8

Longitudinal assessment of growth velocity in relation to pubertal timing, IGF-1, fasting insulin and fat mass in healthy boys

Author(s): Kaspar Sørensen, Casper P Hagen, Lise Aksglæde, Rikke Beck Jensen, Anders Juul
Published in: Endocrine Connections, Issue 15, 2026, ISSN 2049-3614
Publisher: Bioscientifica
DOI: 10.1530/EC-25-0667

Conference proceedings (1)

Leveraging Machine Learning and Genetic Risk Scores for the Prediction of Metabolic Syndrome in Children with Obesity

Author(s): Concepcin M. Aguilera; Mireia Bustos-Aibar; Augusto Anguita-Ruiz; lvaro Torres-Martos; Gloria Bueno; Rosaura Leis; Jess Alcal-Fernndez
Published in: The 14th European Nutrition Conference FENS 2023, 2024
Publisher: MDPI Proceedings
DOI: 10.3390/proceedings2023091377