Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases

Project Information

FIBROTARGET

Grant agreement ID: 101080523

DOI

10.3030/101080523

EC signature date 24 April 2023

Start date 1 April 2023

End date 31 March 2028

Funded under

• Health

Total cost

€ 5 686 450,00

EU contribution

€ 5 686 450,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

MSOT for prognosis and diagnosis of intestinal fibrosis

Report on the results of the MSOT methods

AI solution for prognosis and diagnosis of intestinal fibrosis

Report on development of AI solution for prognosis and diagnosis model on structuring CD

Plan for the dissemination and exploitation including communication activities

Communication and Dissemination strategy, initial tactical plan & tools and strategy to build the sustainability plans

Websites, patent fillings, videos etc. (1)

Project website

Project public website available.

Publications

Peer reviewed articles (9)

Fibroblast Heterogeneity in Inflammatory Bowel Disease

Author(s): Bo-Jun Ke, Gabriele Dragoni, Gianluca Matteoli
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS252313008

Biomarkers for Personalizing IBD Therapy: The Quest Continues

Author(s): Raja Atreya, Markus F. Neurath
Published in: Clinical Gastroenterology and Hepatology, Issue 22, 2024, ISSN 1542-3565
Publisher: Elsevier BV
DOI: 10.1016/j.cgh.2024.01.026

Effect of Mutant and Engineered High-Acetate-Producing Saccharomyces cerevisiae var. boulardii Strains in Dextran Sodium Sulphate-Induced Colitis

Author(s): Sara Deleu, Inge Jacobs, Jorge F. Vazquez Castellanos, Sare Verstockt, Bruna Trindade de Carvalho, Ana Subotić, Bram Verstockt, Kaline Arnauts, Lowie Deprez, Eva Vissers, Matthias Lenfant, Greet Vandermeulen, Gert De Hertogh, Kristin Verbeke, Gianluca Matteoli, Geert R. B. Huys, Johan M. Thevelein, Jeroen Raes, Séverine Vermeire
Published in: Nutrients, Issue 16, 2024, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/NU16162668

Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications

Author(s): Victoria Gudiño; Raquel Bartolomé-Casado; Azucena Salas
Published in: Gut, 2025, ISSN 1468-3288
Publisher: BMJ Group
DOI: 10.1136/GUTJNL-2024-334165

Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease

Author(s): Bo-Jun Ke, Saeed Abdurahiman, Francesca Biscu, Gaia Zanella, Gabriele Dragoni, Sneha Santhosh, Veronica De Simone, Anissa Zouzaf, Lies van Baarle, Michelle Stakenborg, Veronika Bosáková, Yentl Van Rymenant, Emile Verhulst, Sare Verstockt, Elliott Klein, Gabriele Bislenghi, Albert Wolthuis, Jan Frič, Christine Breynaert, Andre D’Hoore, Pieter Van der Veken, Ingrid De Meester, Sara Lovisa, Lukas J.A.C. Hawinkels, Bram Verstockt, Gert De Hertogh, Séverine Vermeire, Gianluca Matteoli
Published in: Journal of Clinical Investigation, Issue 134, 2024, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI173835

Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging

Author(s): Michael Beck, Torsten Kuwert, Armin Atzinger, Maximilian Gerner, Arndt Hartmann, Marc Saake, Michael Uder, Markus Friedrich Neurath, Raja Atreya
Published in: Visceral Medicine, 2024, ISSN 2297-4725
Publisher: S. Karger AG
DOI: 10.1159/000542160

NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases

Author(s): Simone Weber, Selina Sitte, Anna-Lena Voegele, Ludmilla Sologub, Angelika Wilfer, Timo Rath, Andreas Nägel, Sebastian Zundler, Luigi Franchi, Anthony W Opipari, Sophia Sonnewald, Stephen Reid, Arndt Hartmann, Philip Eichhorn, Claudia Handtrack, Klaus Weber, Robert Grützmann, Clemens Neufert, Vera S Schellerer, Elisabeth Naschberger, Arif B Ekici, Christian Büttner, Markus F Neurath, Raja Atreya
Published in: Journal of Crohn's and Colitis, Issue 18, 2024, ISSN 1873-9946
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ecco-jcc/jjad164

Therapeutic potential of Janus kinase inhibitors for the management of fibrosis in inflammatory bowel disease

Author(s): Jie Su; Dalia A Lartey; Gaia Zanella; Lukas J A C Hawinkels; Gianluca Matteoli; Mark Löwenberg; Marieke C Barnhoorn
Published in: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Publisher: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAF087

The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

Author(s): Dragoni, Gabriele; Ke, Bo-Jun; Picariello, Lucia; Abdurahiman, Saeed; Ceni, Elisabetta; Biscu, Francesca; Mello, Tommaso; Polvani, Simone; Innocenti, Tommaso; Spalart, Valérie; Milani, Stefano; D'Hoore, André; Bislenghi, Gabriele; Scaringi, Stefano; Verstockt, Bram; De Hertogh, Gert; Martinod, Kimberly; Galli, Andrea; Matteoli, Gianluca; Vermeire, Séverine
Published in: Journal of Crohn's and Colitis, 2024, ISSN 1876-4479
Publisher: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAE121