Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases

Informazioni relative al progetto

FIBROTARGET

ID dell’accordo di sovvenzione: 101080523

DOI

10.3030/101080523

Data della firma CE 24 Aprile 2023

Data di avvio 1 Aprile 2023

Data di completamento 31 Marzo 2028

Finanziato da

• Health

Costo totale

€ 5 686 450,00

Contributo UE

€ 5 686 450,00

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

MSOT for prognosis and diagnosis of intestinal fibrosis

Report on the results of the MSOT methods

AI solution for prognosis and diagnosis of intestinal fibrosis

Report on development of AI solution for prognosis and diagnosis model on structuring CD

Plan for the dissemination and exploitation including communication activities

Communication and Dissemination strategy, initial tactical plan & tools and strategy to build the sustainability plans

Websites, patent fillings, videos etc. (1)

Project website

Project public website available.

Pubblicazioni

Peer reviewed articles (9)

Fibroblast Heterogeneity in Inflammatory Bowel Disease

Autori: Bo-Jun Ke, Gabriele Dragoni, Gianluca Matteoli
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS252313008

Biomarkers for Personalizing IBD Therapy: The Quest Continues

Autori: Raja Atreya, Markus F. Neurath
Pubblicato in: Clinical Gastroenterology and Hepatology, Numero 22, 2024, ISSN 1542-3565
Editore: Elsevier BV
DOI: 10.1016/j.cgh.2024.01.026

Effect of Mutant and Engineered High-Acetate-Producing Saccharomyces cerevisiae var. boulardii Strains in Dextran Sodium Sulphate-Induced Colitis

Autori: Sara Deleu, Inge Jacobs, Jorge F. Vazquez Castellanos, Sare Verstockt, Bruna Trindade de Carvalho, Ana Subotić, Bram Verstockt, Kaline Arnauts, Lowie Deprez, Eva Vissers, Matthias Lenfant, Greet Vandermeulen, Gert De Hertogh, Kristin Verbeke, Gianluca Matteoli, Geert R. B. Huys, Johan M. Thevelein, Jeroen Raes, Séverine Vermeire
Pubblicato in: Nutrients, Numero 16, 2024, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/NU16162668

Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications

Autori: Victoria Gudiño; Raquel Bartolomé-Casado; Azucena Salas
Pubblicato in: Gut, 2025, ISSN 1468-3288
Editore: BMJ Group
DOI: 10.1136/GUTJNL-2024-334165

Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease

Autori: Bo-Jun Ke, Saeed Abdurahiman, Francesca Biscu, Gaia Zanella, Gabriele Dragoni, Sneha Santhosh, Veronica De Simone, Anissa Zouzaf, Lies van Baarle, Michelle Stakenborg, Veronika Bosáková, Yentl Van Rymenant, Emile Verhulst, Sare Verstockt, Elliott Klein, Gabriele Bislenghi, Albert Wolthuis, Jan Frič, Christine Breynaert, Andre D’Hoore, Pieter Van der Veken, Ingrid De Meester, Sara Lovisa, Lukas J.A.C. Hawinkels, Bram Verstockt, Gert De Hertogh, Séverine Vermeire, Gianluca Matteoli
Pubblicato in: Journal of Clinical Investigation, Numero 134, 2024, ISSN 1558-8238
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI173835

Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging

Autori: Michael Beck, Torsten Kuwert, Armin Atzinger, Maximilian Gerner, Arndt Hartmann, Marc Saake, Michael Uder, Markus Friedrich Neurath, Raja Atreya
Pubblicato in: Visceral Medicine, 2024, ISSN 2297-4725
Editore: S. Karger AG
DOI: 10.1159/000542160

NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases

Autori: Simone Weber, Selina Sitte, Anna-Lena Voegele, Ludmilla Sologub, Angelika Wilfer, Timo Rath, Andreas Nägel, Sebastian Zundler, Luigi Franchi, Anthony W Opipari, Sophia Sonnewald, Stephen Reid, Arndt Hartmann, Philip Eichhorn, Claudia Handtrack, Klaus Weber, Robert Grützmann, Clemens Neufert, Vera S Schellerer, Elisabeth Naschberger, Arif B Ekici, Christian Büttner, Markus F Neurath, Raja Atreya
Pubblicato in: Journal of Crohn's and Colitis, Numero 18, 2024, ISSN 1873-9946
Editore: Oxford University Press (OUP)
DOI: 10.1093/ecco-jcc/jjad164

Therapeutic potential of Janus kinase inhibitors for the management of fibrosis in inflammatory bowel disease

Autori: Jie Su; Dalia A Lartey; Gaia Zanella; Lukas J A C Hawinkels; Gianluca Matteoli; Mark Löwenberg; Marieke C Barnhoorn
Pubblicato in: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Editore: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAF087

The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

Autori: Dragoni, Gabriele; Ke, Bo-Jun; Picariello, Lucia; Abdurahiman, Saeed; Ceni, Elisabetta; Biscu, Francesca; Mello, Tommaso; Polvani, Simone; Innocenti, Tommaso; Spalart, Valérie; Milani, Stefano; D'Hoore, André; Bislenghi, Gabriele; Scaringi, Stefano; Verstockt, Bram; De Hertogh, Gert; Martinod, Kimberly; Galli, Andrea; Matteoli, Gianluca; Vermeire, Séverine
Pubblicato in: Journal of Crohn's and Colitis, 2024, ISSN 1876-4479
Editore: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAE121