Continuous stratification for improved prevention, treatment, and rehabilitation of stroke patients using digital twins and AI

Informations projet

STRATIF-AI

N° de convention de subvention: 101080875

DOI

10.3030/101080875

Date de signature de la CE 21 Avril 2023

Date de début 1 Mai 2023

Date de fin 30 Avril 2027

Financé au titre de

• Health

Coût total

€ 5 698 475,00

Contribution de l’UE

€ 5 698 475,00

Coordonné par

LINKOPINGS UNIVERSITET
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (8)

Startup package for clinical study 3

Submission package, prior to enrolment of first subject in Clinical study 3. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Startup package for clinical study 5

Submission package, prior to enrolment of first subject in Clinical study 5. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Submitted ethical applications

Submitted ethical applications for all 6 clinical studies

Startup package for clinical study 4

Submission package, prior to enrolment of first subject in Clinical study 4. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Dissemination and Communication Plan including Home Page

Communication and dissemination plan for the project, including development of the home page.

Startup package for clinical study 2

Submission package, prior to enrolment of first subject in Clinical study 2. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Startup package for clinical study 6

Submission package, prior to enrolment of first subject in Clinical study 6. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Startup package for clinical study 1

Submission package, prior to enrolment of first subject in Clinical study 1. This contains the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities. This deliverable is available prior to enrolment of the first subject in clinical studies.

Publications

Peer reviewed articles (10)

Engineering Applications of Artificial Intelligence

Auteurs: Abad-Navarro, Francisco; Martínez Costa, Catalina; Fernández Breis, Jesualdo Tomás
Publié dans: Engineering Applications of Artificial Intelligence, 2025, ISSN 0952-1976
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/J.ENGAPPAI.2025.112671

A physiologically-based digital twin for alcohol consumption – predicting real-life drinking responses and long-term plasma PEth

Auteurs: Henrik Podéus; Christian Simonsson; William Lövfors; Patrik Nasr; Mattias Ekstedt; Peter Lundberg; Gunnar Cedersund; Stergios Kechagias; Henrik Podéus; Christian Simonsson; Patrik Nasr; Mattias Ekstedt; Stergios Kechagias; Peter Lundberg; William Lövfors; Gunnar Cedersund
Publié dans: npj Digital Medicine, Numéro 7, 2024, ISSN 2398-6352
Éditeur: Nature publishing group
DOI: 10.1038/S41746-024-01089-6

HURON: A Quantitative Framework for Assessing Human Readability in Ontologies

Auteurs: Francisco Abad-Navarro, Catalina Martínez-Costa, Jesualdo Tomás Fernández-Breis
Publié dans: IEEE Access, Numéro 11, 2023, ISSN 2169-3536
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/ACCESS.2023.3316512

Model-driven meta-analysis establishes a new consensus view: Inhibitory neurons dominate BOLD-fMRI responses

Auteurs: Nicolas Sundqvist; Henrik Podéus; Sebastian Sten; Maria Engström; Salvador Dura-Bernal; Gunnar Cedersund
Publié dans: Computers in Biology and Medicine, 2025, ISSN 1879-0534
Éditeur: Science direct
DOI: 10.1016/J.COMPBIOMED.2025.111014

How processing choices effect repeatability in BOLD–CVR imaging

Auteurs: Gustav Magnusson, Alex A Bhogal, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Maria Engström, Anders Tisell
Publié dans: Journal of Cerebral Blood Flow & Metabolism, 2026, ISSN 0271-678X
Éditeur: SAGE Publications
DOI: 10.1177/0271678X261420026

A unified framework for prediction of liver steatosis dynamics in response to different diet and drug interventions

Auteurs: Christian Simonsson, Elin Nyman, Peter Gennemark, Peter Gustafsson, Ingrid Hotz, Mattias Ekstedt, Peter Lundberg, Gunnar Cedersund
Publié dans: Clinical Nutrition, Numéro 43, 2024, ISSN 0261-5614
Éditeur: Elsevier BV
DOI: 10.1016/J.CLNU.2024.05.017

Predictors of social risk for post-ischemic stroke reintegration

Auteurs: Katryna K. Cisek, Thi Nguyet Que Nguyen, Alejandro Garcia-Rudolph, Joan Saurí, Helard Becerra Martinez, Andrew Hines, John D. Kelleher
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-60507-7

Uncertainty in cardiovascular digital twins despite non-normal errors in 4D flow MRI: identifying reliable biomarkers such as ventricular relaxation rate

Auteurs: Kajsa Tunedal; Tino Ebbers; Gunnar Cedersund
Publié dans: Computers in Biology and Medicine, 2024, ISSN 1879-0534
Éditeur: Elsevier
DOI: 10.1016/J.COMPBIOMED.2025.109878

Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation

Auteurs: Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman
Publié dans: Journal of Biological Chemistry, Numéro 299, 2023, ISSN 0021-9258
Éditeur: Journal of Biological Chemistry
DOI: 10.1016/j.jbc.2023.105205

Characterization, Outcomes, and Time to Event Predictors of Urinary Tract Infections Acquired During Postacute Stroke Inpatient Rehabilitation: A Comprehensive Cohort Study

Auteurs: Alejandro García-Rudolph; Sergiu Albu; Mark Andrew Wright; Maria del Mar Laya; Claudia Teixido; Eloy Opisso; Gunnar Cedersund; Montserrat Bernabeu
Publié dans: Archives of Physical Medicine and Rehabilitation, 2025, ISSN 1532-821X
Éditeur: ACRM
DOI: 10.1016/J.APMR.2024.10.007

Book chapters (4)

‘SNOMEDizing’ Questionnaires for Standardizing Stroke Registry Data

Auteurs: Andrea Riedel, Stefan Schulz, Catalina Martínez Costa
Publié dans: Digital Health and Informatics Innovations for Sustainable Health Care Systems, Numéro 1453
Éditeur: IOS Press
DOI: 10.3233/SHTI240687

‘SNOMEDizing’ Questionnaires for Standardizing Stroke Registry Data

Auteurs: Riedel, Andrea; Schulz, Stefan; Martínez Costa, Catalina
Publié dans: Studies in Health Technology and Informatics - Digital Health and Informatics Innovations for Sustainable Health Care Systems, 2024
Éditeur: SAGE
DOI: 10.3233/SHTI240687

Semantic Representation of Medical Data Collection Forms Using Standards

Auteurs: Schulz, Stefan; Martínez Costa, Catalina
Publié dans: Studies in Health Technology and Informatics, Intelligent Health Systems – From Technology to Data and Knowledge, 2025
Éditeur: SAGE
DOI: 10.3233/SHTI250440

Estimating Population Burden of Stroke with an Agent-Based Model

Auteurs: Elizabeth Hunter; John D. Kelleher
Publié dans: Springer Proceedings in Complexity ISBN: 9783031577840, 2024
Éditeur: Springer
DOI: 10.48550/ARXIV.2405.19934