Descripción del proyecto
Síntesis sostenible de aminoalcoholes mediante cascadas enzimáticas
Los aminoalcoholes y las dihidroxicetonas representan productos valiosos para el sector químico y farmacéutico, pero resultan complicados de sintetizar. En la actualidad suelen producirse en países con malas condiciones laborales y normas medioambientales y de seguridad laxas. Un innovador proceso ya ha sentado la base para una alternativa sostenible, utilizando una reacción atómica y enzimática eficiente de dos pasos para la producción de aminoalcoholes a partir de materiales económicos. El objetivo del proyecto SusECAS - DemoPlant, financiado por el Consejo Europeo de Investigación, es lograr avanzar con esta innovadora idea de síntesis hasta el nivel de aplicación industrial. Una planta de demostración de varios gramos permitirá una evaluación del proceso y la comprobación de su potencial ecológico y económico. El proyecto llevará a cabo un análisis sistemático del mercado y desarrollará un plan de negocio para la comercialización y la introducción en el mercado de los productos y la tecnología.
Objetivo
The development of more environmentally friendly synthesis methods is urgently needed if humanity wants to maintain an environment worth living in. The establishment of more biocatalytic steps in chemical synthesis is a possible solution, as enzymes and whole cells offer sustainable advantages such as biodegradability, toxicity, high selectivity and much more.
Amino alcohols and 2-hydroxy ketones are valuable compounds with various applications in the chemical and pharmaceutical industry with market prices >1000 €/kg, but challenging synthesis strategies. As a result of synthesis options with disastrous footprints, these molecules are often produced in countries with poor working conditions and significantly lower safety and environmental standards than those accepted in the EU.
The idea of 'SusECAS - DemoPlant' is simple. An innovative economic and ecological competitive process will enable a sustainable production of amino alcohols in Europe. In the ERC Starting Grant project 'LightCas', Prof. Rother laid the base with an atomic and step-efficient enzymatic 2-step reaction for amino alcohols from inexpensive starting materials (<10-100 €/kg). In 'SusECAS' we will take these innovative synthesis ideas to a new level of industrial application. A multi-gram demonstration plant will enable model-based process evaluation, giving us and our customer’s clear indications of the ecological and economic potential. A systematic market analysis will provide an overview of the competitive structure of the overall market, the market volume and the requirements of potential customers. Supported by business angels, commercialization strategies will be evaluated. In 'SusECAS', we will develop a business plan for commercialization and initiate a step-by-step market introduction of our products and technologies.
Ámbito científico
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencesorganic chemistryketones
- natural scienceschemical sciencesorganic chemistryalcohols
- social scienceseconomics and businesseconomicssustainable economy
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-AG-LS - HORIZON Lump Sum GrantInstitución de acogida
52428 Julich
Alemania