Rescue Pacing for Congenital Complete Heart Block

Project Information

RescuePace

Grant agreement ID: 101081921

DOI

10.3030/101081921

Project closed

EC signature date 7 July 2022

Start date 1 August 2022

End date 31 January 2024

Funded under

• European Research Council (ERC)

Total cost

No data

EU contribution

€ 150 000,00

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

Periodic Reporting for period 1 - RescuePace (Rescue Pacing for Congenital Complete Heart Block)

Reporting period: 2022-08-01 to 2024-01-31

Summary of the context and overall objectives of the project

To enable successful implementation of cardiac gene therapies it is of critical importance to develop improved gene transfer methods to target the heart and/or vascular system. In this project we therefore explored novel gene transfer method. Our initial efforts have been directed towards the field of gene therapy-based biological pacing. Our newly identified gene transfer methods are instrumental to the broader field of cardiovascular gene therapy.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

The experimental work that we performed focused on two vector system with high tropism for the heart, adenoviral vectors (AdV) and adeno associated viral vectors (AAV). For both vector systems we identified methods and/or new variants with high potential for translational development in the context of biological pacing and the broader field of cardiovascular gene therapy.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

We identified methods and/or new vector variants with high potential for translational development in the context of biological pacing and the broader field of cardiovascular gene therapy.