Rescue Pacing for Congenital Complete Heart Block

Project description

Gene therapy for congenital heart block

The rhythmic pumping function of the heart muscle is mediated by a built-in electrical system. In congenital complete heart block (CCHB) this system malfunctions due to structural defects or autoimmunity, causing abnormal propagation of electrical impulses in the heart. CCHB is diagnosed in utero, at birth or during the first months of life and is associated with bradycardia. The only treatment is the implantation of a permanent pacemaker. The ERC-based RescuePace project proposes a gene therapy approach to treat CCHB. The procedure entails the administration of an adenoviral vector that expresses ion channels in the heart to increase the heart rate and allow the patient to survive until birth, when a pacemaker can be implanted.

Fields of science

• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › cardiac arrhythmia
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs

Programme(s)

• HORIZON.1.1 - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2022-POC2 - ERC PROOF OF CONCEPT GRANTS2

Call for proposal

ERC-2022-POC2

See other projects for this call

Funding Scheme

ERC-POC - Proof of Concept Grant

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Net EU contribution

€ 150 000,00

Address

Meibergdreef 15
1105AZ Amsterdam
Netherlands

Region

West-Nederland › Noord-Holland › Groot-Amsterdam

Activity type

Higher or Secondary Education Establishments

Links

Other funding

No data