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Psychiatric disorders and Comorbidities caused by pollution in the Mediterranean area

Description du projet

Le lien entre les polluants anthropiques et les troubles psychiatriques

La pollution a été associée à des troubles et à des comorbidités psychiatriques. Le projet PsyCoMed, financé par l’UE, étudiera le rôle des polluants anthropiques en tant que facteurs de risque pour les troubles neuropsychiatriques et les pathologies associées, dans la région méditerranéenne. Il étudiera le rôle des réponses neuro-inflammatoires dans la progression de la maladie. Ce programme d’échange de personnel MSCA conjuguera les sciences moléculaires et cliniques, les approches mécanistes et comportementales et les stratégies intersectorielles pour comparer les effets des polluants sur les symptômes psychiatriques avec les altérations des voies inflammatoires dans des modèles animaux ainsi que chez les patients psychiatriques. En étudiant les mécanismes neuronaux à l’origine des changements pathologiques dans des modèles précliniques in vitro et in vivo, le projet a pour ambition de normaliser les protocoles et la conception expérimentale, et de proposer des stratégies thérapeutiques.

Objectif

The PSYchiatric disorders and COmorbidities caused by pollution in the MEDiterranean area (PsyCoMed) project proposes a MSCA-Staff Exchange program that aims to characterise the role of anthropogenic pollutants in the Mediterranean area as a risk factor of neuropsychiatric disorders and associated pathologies, and the role of neuroinflammatory responses in the disease progression. The consortium comprises 11 beneficiaries (8 academic, 3 SMEs) and 3 TC partners putting together complementary expertises in environmental and life sciences (academics) and analytical biology or natural therapeutic phytocompounds (SMEs). Through a multi-scale (from molecular to clinical science), multi-modal (from mechanistic to behavioural approaches), and inter-sectoral strategy, PsyCoMed will correlate the effects of pollutants on psychiatric symptoms with alterations of inflammatory pathways in animal models and psychiatric patients. We will investigate neural mechanisms underlying pathological changes in vitro and in in vivo preclinical models. Natural substances with therapeutic potential will be tested for their ability to restore healthy mechanisms and alleviate pathological symptoms in animal models. PsyCoMed offers a unique framework to build a network synergy by bringing together themes and scientific practises in the Mediterranean area. The partners will share knowledge/know-how through secondments and workshops in support of PsyCoMed scientific objectives. This will improve the skills of staff members and their opening to the academic and private sectors. By proposing common protocols and experimental design, the participants will foster standardization of experimental procedures and diffusion of good laboratory practise. At a global level, the consortium will acquire the capacity to tackle complex neurobiological challenges, while building long-lasting collaborations. PsyCoMed will provide decision-makers with the ground for public health orientations with societal impact.

Coordinateur

UNIVERSITE DE BORDEAUX
Contribution nette de l'UE
€ 262 200,00
Adresse
Place pey berland 35
33000 Bordeaux
France

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Région
Nouvelle-Aquitaine Aquitaine Gironde
Type d’activité
Higher or Secondary Education Establishments
Liens
Contribution de l’UE
Aucune donnée

Participants (9)

Partenaires (4)