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Psychiatric disorders and Comorbidities caused by pollution in the Mediterranean area

Descrizione del progetto

Nesso tra inquinanti antropogenici e disturbi psichiatrici

L’inquinamento è stato messo in relazione a disturbi psichiatrici e comorbidità. Il progetto PsyCoMed, finanziato dall’UE, esaminerà il ruolo degli inquinanti antropici come fattore di rischio per disturbi neuropsichiatrici e relative patologie nell’area del Mediterraneo, studiando il ruolo delle risposte neuroinfiammatorie nella progressione della malattia. Questo programma MSCA di scambio del personale congiungerà scienza molecolare e clinica, approcci meccanicistici e comportamentali e strategie intersettoriali per confrontare gli effetti degli inquinanti sui sintomi psichiatrici con alterazioni delle vie infiammatorie in modelli animali e pazienti psichiatrici. Studiando i meccanismi neurali alla base dei cambiamenti patologici in modelli preclinici in vitro e in vivo, il progetto si propone di standardizzare i protocolli e il disegno sperimentale, nonché di proporre strategie terapeutiche.

Obiettivo

The PSYchiatric disorders and COmorbidities caused by pollution in the MEDiterranean area (PsyCoMed) project proposes a MSCA-Staff Exchange program that aims to characterise the role of anthropogenic pollutants in the Mediterranean area as a risk factor of neuropsychiatric disorders and associated pathologies, and the role of neuroinflammatory responses in the disease progression. The consortium comprises 11 beneficiaries (8 academic, 3 SMEs) and 3 TC partners putting together complementary expertises in environmental and life sciences (academics) and analytical biology or natural therapeutic phytocompounds (SMEs). Through a multi-scale (from molecular to clinical science), multi-modal (from mechanistic to behavioural approaches), and inter-sectoral strategy, PsyCoMed will correlate the effects of pollutants on psychiatric symptoms with alterations of inflammatory pathways in animal models and psychiatric patients. We will investigate neural mechanisms underlying pathological changes in vitro and in in vivo preclinical models. Natural substances with therapeutic potential will be tested for their ability to restore healthy mechanisms and alleviate pathological symptoms in animal models. PsyCoMed offers a unique framework to build a network synergy by bringing together themes and scientific practises in the Mediterranean area. The partners will share knowledge/know-how through secondments and workshops in support of PsyCoMed scientific objectives. This will improve the skills of staff members and their opening to the academic and private sectors. By proposing common protocols and experimental design, the participants will foster standardization of experimental procedures and diffusion of good laboratory practise. At a global level, the consortium will acquire the capacity to tackle complex neurobiological challenges, while building long-lasting collaborations. PsyCoMed will provide decision-makers with the ground for public health orientations with societal impact.

Coordinatore

UNIVERSITE DE BORDEAUX
Contribution nette de l'UE
€ 262 200,00
Indirizzo
PLACE PEY BERLAND 35
33000 Bordeaux
Francia

Mostra sulla mappa

Regione
Nouvelle-Aquitaine Aquitaine Gironde
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partecipanti (9)

Partner (4)