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Heparanase inhibition as a multifunctional targeting approach in cancer

Deliverables

Plan for dissemination and exploitation including communication activities
Secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways

Report on the secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways (R, Month 12).

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype (R, month 18)

Publications

The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor

Author(s): Nourhan Hassan; Nico Bückreiß; Janes Efing; Marie Schulz-Fincke; Philipp König; Burkhard Greve; Gerd Bendas; Martin Götte
Published in: Cells, Issue Volume 12; Issue 6; Pages: 910, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12060910

Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets

Author(s): Oto J, Le QK, Schäfer SD, Kiesel L, Marí-Alexandre J, Gilabert-Estellés J, Medina P, Götte M.
Published in: Cancers, Issue 15(12):3125, 2023, ISSN 2072-6694
Publisher: MDPI
DOI: 10.3390/cancers15123125

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis

Author(s): Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, P. Singh, G. Bar-Sela, H. Goldberg, Martin Götte, A. D. Sharrocks, Y. Li, R. D. Sanderson, N. Ilan, I. Vlodavsky
Published in: Cell Death & Disease, Issue 232, 2024, ISSN 2041-4889
Publisher: Nature Publishing group
DOI: 10.1038/s41419-024-06596-8

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans

Author(s): Nourhan Hassan; Janes Efing; Ludwig Kiesel; Gerd Bendas; Martin Götte
Published in: Cancers, Issue 12(6):910, 2023, ISSN 2072-6694
Publisher: MDPI
DOI: 10.3390/cancers15051524

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