Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Heparanase inhibition as a multifunctional targeting approach in cancer

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Plan for dissemination and exploitation including communication activities (opens in new window)
Secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways (opens in new window)

Report on the secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways (R, Month 12).

Biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition (opens in new window)

Report on biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition (R, Month 24)

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype (opens in new window)

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype (R, month 18)

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment (opens in new window)

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment (R, month 28)

Specific glycosaminoglycan spectral signature (opens in new window)

Report on the specific glycosaminoglycan spectral signature (R, month 18).

Preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG (opens in new window)

Report on the preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG.

Publications

The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor (opens in new window)

Author(s): Nourhan Hassan; Nico Bückreiß; Janes Efing; Marie Schulz-Fincke; Philipp König; Burkhard Greve; Gerd Bendas; Martin Götte
Published in: Cells, Issue Volume 12; Issue 6; Pages: 910, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12060910

International Journal of Molecular Sciences (opens in new window)

Author(s): Cinzia Cocola; Edoardo Abeni; Valentina Martino; Eleonora Piscitelli; Paride Pelucchi; Ettore Mosca; Alice Chiodi; Tasnim Mohamed; Mira Palizban; Giovanni Porta; Helga Palizban; Giovanni Nano; Francesco Acquati; Antonino Bruno; Burkhard Greve; Daniela Gerovska; Valerio Magnaghi; Daniela Mazzaccaro; Giovanni Bertalot; James Kehler; Cristiana Balbino; Marcos J. Arauzo-Bravo; Martin Gtte; Ileana Zucchi; Rolland A. Reinbold
Published in: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25073967

International Journal of Molecular Sciences (opens in new window)

Author(s): Eleonora Piscitelli; Edoardo Abeni; Cristiana Balbino; Elena Angeli; Cinzia Cocola; Paride Pelucchi; Mira Palizban; Alberto Diaspro; Martin Götte; Ileana Zucchi; Rolland A. Reinbold
Published in: International Journal of Molecular Sciences, Issue 26(6), 2025, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/IJMS26062412

The Analyst (opens in new window)

Author(s): Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Published in: The Analyst, Issue 150:1280, 2025, ISSN 0003-2654
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets (opens in new window)

Author(s): Oto J, Le QK, Schäfer SD, Kiesel L, Marí-Alexandre J, Gilabert-Estellés J, Medina P, Götte M.
Published in: Cancers, Issue 15(12):3125, 2023, ISSN 2072-6694
Publisher: MDPI
DOI: 10.3390/cancers15123125

Nanoparticles and Glycosaminoglycans: Progress and Applications for Cancer Therapy (opens in new window)

Author(s): Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Published in: Proteoglycan Research, Issue 3:e70024, 2025, ISSN 2832-3556
Publisher: Wiley
DOI: 10.1002/PGR2.70024

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis (opens in new window)

Author(s): Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, P. Singh, G. Bar-Sela, H. Goldberg, Martin Götte, A. D. Sharrocks, Y. Li, R. D. Sanderson, N. Ilan, I. Vlodavsky
Published in: Cell Death & Disease, Issue 232, 2024, ISSN 2041-4889
Publisher: Nature Publishing group
DOI: 10.1038/s41419-024-06596-8

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans (opens in new window)

Author(s): Nourhan Hassan; Janes Efing; Ludwig Kiesel; Gerd Bendas; Martin Götte
Published in: Cancers, Issue 12(6):910, 2023, ISSN 2072-6694
Publisher: MDPI
DOI: 10.3390/cancers15051524

Extracellular vesicles derived from ovarian cancer cell lines discriminated by biochemical and Fourier transform infrared spectroscopy approaches (opens in new window)

Author(s): Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Published in: The Analyst, 2025, ISSN 0003-2654
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells (opens in new window)

Author(s): Jessica Oyie Sousa Onyeisi, Heba M. El-Shorafa, Burkhard Greve, Martin Götte
Published in: Matrix Biology, Issue 136, 2025, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/J.MATBIO.2025.02.002

Role of TMEM230 in the Aberrant Glycosylation in Human Autoimmunity and Cancer (opens in new window)

Author(s): Elena Angeli, Cinzia Cocola, Edoardo Abeni, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Luca Lerma, Cristiana Balbino, Ileana Zucchi, Mira Palizban, Martin Götte, Alberto Diaspro, Rolland A. Reinbold
Published in: Proteoglycan Research, Issue 3, e70020, 2025, ISSN 2832-3556
Publisher: Wiley
DOI: 10.1002/PGR2.70020

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available

My booklet 0 0