Heparanase inhibition as a multifunctional targeting approach in cancer

Informazioni relative al progetto

HEPINIB

ID dell’accordo di sovvenzione: 101086322

DOI

10.3030/101086322

Data della firma CE 28 Ottobre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 437 000,00

Coordinato da

UNIVERSITAET MUENSTER
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Social media and web pages

Social media and web pages month 3

Documents, reports (7)

Plan for dissemination and exploitation including communication activities
Secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways

Report on the secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways (R, Month 12).

Biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition

Report on biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition (R, Month 24)

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype (R, month 18)

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment (R, month 28)

Specific glycosaminoglycan spectral signature

Report on the specific glycosaminoglycan spectral signature (R, month 18).

Preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG

Report on the preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG.

Data Management Plan (1)

Data management plan

Data Management plan

Pubblicazioni

Peer reviewed articles (11)

The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor

Autori: Nourhan Hassan; Nico Bückreiß; Janes Efing; Marie Schulz-Fincke; Philipp König; Burkhard Greve; Gerd Bendas; Martin Götte
Pubblicato in: Cells, Numero Volume 12; Numero 6; Pages: 910, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12060910

International Journal of Molecular Sciences

Autori: Cinzia Cocola; Edoardo Abeni; Valentina Martino; Eleonora Piscitelli; Paride Pelucchi; Ettore Mosca; Alice Chiodi; Tasnim Mohamed; Mira Palizban; Giovanni Porta; Helga Palizban; Giovanni Nano; Francesco Acquati; Antonino Bruno; Burkhard Greve; Daniela Gerovska; Valerio Magnaghi; Daniela Mazzaccaro; Giovanni Bertalot; James Kehler; Cristiana Balbino; Marcos J. Arauzo-Bravo; Martin Gtte; Ileana Zucchi; Rolland A. Reinbold
Pubblicato in: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25073967

International Journal of Molecular Sciences

Autori: Eleonora Piscitelli; Edoardo Abeni; Cristiana Balbino; Elena Angeli; Cinzia Cocola; Paride Pelucchi; Mira Palizban; Alberto Diaspro; Martin Götte; Ileana Zucchi; Rolland A. Reinbold
Pubblicato in: International Journal of Molecular Sciences, Numero 26(6), 2025, ISSN 1422-0067
Editore: MDPI
DOI: 10.3390/IJMS26062412

The Analyst

Autori: Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Pubblicato in: The Analyst, Numero 150:1280, 2025, ISSN 0003-2654
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets

Autori: Oto J, Le QK, Schäfer SD, Kiesel L, Marí-Alexandre J, Gilabert-Estellés J, Medina P, Götte M.
Pubblicato in: Cancers, Numero 15(12):3125, 2023, ISSN 2072-6694
Editore: MDPI
DOI: 10.3390/cancers15123125

Nanoparticles and Glycosaminoglycans: Progress and Applications for Cancer Therapy

Autori: Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Pubblicato in: Proteoglycan Research, Numero 3:e70024, 2025, ISSN 2832-3556
Editore: Wiley
DOI: 10.1002/PGR2.70024

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis

Autori: Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, P. Singh, G. Bar-Sela, H. Goldberg, Martin Götte, A. D. Sharrocks, Y. Li, R. D. Sanderson, N. Ilan, I. Vlodavsky
Pubblicato in: Cell Death & Disease, Numero 232, 2024, ISSN 2041-4889
Editore: Nature Publishing group
DOI: 10.1038/s41419-024-06596-8

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans

Autori: Nourhan Hassan; Janes Efing; Ludwig Kiesel; Gerd Bendas; Martin Götte
Pubblicato in: Cancers, Numero 12(6):910, 2023, ISSN 2072-6694
Editore: MDPI
DOI: 10.3390/cancers15051524

Extracellular vesicles derived from ovarian cancer cell lines discriminated by biochemical and Fourier transform infrared spectroscopy approaches

Autori: Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Pubblicato in: The Analyst, 2025, ISSN 0003-2654
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells

Autori: Jessica Oyie Sousa Onyeisi, Heba M. El-Shorafa, Burkhard Greve, Martin Götte
Pubblicato in: Matrix Biology, Numero 136, 2025, ISSN 0945-053X
Editore: Elsevier BV
DOI: 10.1016/J.MATBIO.2025.02.002

Role of TMEM230 in the Aberrant Glycosylation in Human Autoimmunity and Cancer

Autori: Elena Angeli, Cinzia Cocola, Edoardo Abeni, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Luca Lerma, Cristiana Balbino, Ileana Zucchi, Mira Palizban, Martin Götte, Alberto Diaspro, Rolland A. Reinbold
Pubblicato in: Proteoglycan Research, Numero 3, e70020, 2025, ISSN 2832-3556
Editore: Wiley
DOI: 10.1002/PGR2.70020