Heparanase inhibition as a multifunctional targeting approach in cancer

Información del proyecto

HEPINIB

Identificador del acuerdo de subvención: 101086322

DOI

10.3030/101086322

Fecha de la firma de la CE 28 Octubre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 437 000,00

Coordinado por

UNIVERSITAET MUENSTER
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Social media and web pages

Social media and web pages month 3

Documents, reports (7)

Plan for dissemination and exploitation including communication activities
Secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways

Report on the secretome of two tumour cell lines in response to latent and active HPSE and impact of HSPG cleavage and interference with signalling pathways (R, Month 12).

Biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition

Report on biosensor data to derive a potential receptor activity in HPSE signalling and its inhibition (R, Month 24)

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype

Evaluation of HPSE and HPSE inhibitor impact on the breast and colon cancer CSC phenotype (R, month 18)

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment

Report on the impact of HS/HPSE inhibitor treatment on the inflammatory microenvironment (R, month 28)

Specific glycosaminoglycan spectral signature

Report on the specific glycosaminoglycan spectral signature (R, month 18).

Preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG

Report on the preparation of at least 4 new inhibitors, and of SPION@DA-BSA/DA-GAG.

Data Management Plan (1)

Data management plan

Data Management plan

Publicaciones

Peer reviewed articles (11)

The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor

Autores: Nourhan Hassan; Nico Bückreiß; Janes Efing; Marie Schulz-Fincke; Philipp König; Burkhard Greve; Gerd Bendas; Martin Götte
Publicado en: Cells, Edición Volume 12; Edición 6; Pages: 910, 2023, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12060910

International Journal of Molecular Sciences

Autores: Cinzia Cocola; Edoardo Abeni; Valentina Martino; Eleonora Piscitelli; Paride Pelucchi; Ettore Mosca; Alice Chiodi; Tasnim Mohamed; Mira Palizban; Giovanni Porta; Helga Palizban; Giovanni Nano; Francesco Acquati; Antonino Bruno; Burkhard Greve; Daniela Gerovska; Valerio Magnaghi; Daniela Mazzaccaro; Giovanni Bertalot; James Kehler; Cristiana Balbino; Marcos J. Arauzo-Bravo; Martin Gtte; Ileana Zucchi; Rolland A. Reinbold
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25073967

International Journal of Molecular Sciences

Autores: Eleonora Piscitelli; Edoardo Abeni; Cristiana Balbino; Elena Angeli; Cinzia Cocola; Paride Pelucchi; Mira Palizban; Alberto Diaspro; Martin Götte; Ileana Zucchi; Rolland A. Reinbold
Publicado en: International Journal of Molecular Sciences, Edición 26(6), 2025, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/IJMS26062412

The Analyst

Autores: Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Publicado en: The Analyst, Edición 150:1280, 2025, ISSN 0003-2654
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets

Autores: Oto J, Le QK, Schäfer SD, Kiesel L, Marí-Alexandre J, Gilabert-Estellés J, Medina P, Götte M.
Publicado en: Cancers, Edición 15(12):3125, 2023, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/cancers15123125

Nanoparticles and Glycosaminoglycans: Progress and Applications for Cancer Therapy

Autores: Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Publicado en: Proteoglycan Research, Edición 3:e70024, 2025, ISSN 2832-3556
Editor: Wiley
DOI: 10.1002/PGR2.70024

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis

Autores: Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, P. Singh, G. Bar-Sela, H. Goldberg, Martin Götte, A. D. Sharrocks, Y. Li, R. D. Sanderson, N. Ilan, I. Vlodavsky
Publicado en: Cell Death & Disease, Edición 232, 2024, ISSN 2041-4889
Editor: Nature Publishing group
DOI: 10.1038/s41419-024-06596-8

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans

Autores: Nourhan Hassan; Janes Efing; Ludwig Kiesel; Gerd Bendas; Martin Götte
Publicado en: Cancers, Edición 12(6):910, 2023, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/cancers15051524

Extracellular vesicles derived from ovarian cancer cell lines discriminated by biochemical and Fourier transform infrared spectroscopy approaches

Autores: Lefkothea Pantazi, Valérie Untereiner, Paolo Rosales, Romain Rivet, Sandra Audonnet, Isabelle Proult, Laurent Ramont, Ganesh D. Sockalingum, Stéphane Brézillon
Publicado en: The Analyst, 2025, ISSN 0003-2654
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5AN00024F

Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells

Autores: Jessica Oyie Sousa Onyeisi, Heba M. El-Shorafa, Burkhard Greve, Martin Götte
Publicado en: Matrix Biology, Edición 136, 2025, ISSN 0945-053X
Editor: Elsevier BV
DOI: 10.1016/J.MATBIO.2025.02.002

Role of TMEM230 in the Aberrant Glycosylation in Human Autoimmunity and Cancer

Autores: Elena Angeli, Cinzia Cocola, Edoardo Abeni, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Luca Lerma, Cristiana Balbino, Ileana Zucchi, Mira Palizban, Martin Götte, Alberto Diaspro, Rolland A. Reinbold
Publicado en: Proteoglycan Research, Edición 3, e70020, 2025, ISSN 2832-3556
Editor: Wiley
DOI: 10.1002/PGR2.70020