Project description DEENESFRITPL Advancing bone tissue research Reliable and sustainable 3D in vitro cell models of healthy and aged bone tissue are critical for advancing our understanding of bone biology and developing new treatments for bone-related diseases. Their development requires expertise from multiple disciplines, including cell biology, biomechanics, biomaterials and tissue engineering. With the support of the Marie Skłodowska-Curie Actions programme, the OSTEONET project will bring together experts from technical and medical disciplines to increase knowledge on the effects of ageing on bone biology and mechanobiology. It will train a cohort of scientists and technologists to leverage the use of 3D cell models in clinics and basic/industrial research labs. OSTEONET will contribute to the development of personalised therapies and better preventive care for the elderly. Show the project objective Hide the project objective Objective OSTEONET aims to (i) build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable 3D in vitro cell models of healthy and aged bone tissue and (ii) train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of ageing on bone biology and mechanobiology, and on bone response to drugs, to leverage the use of 3D cell models in clinics and basic/industrial research labs.Bone ageing reduces the quality of life of the elderly and puts social and economic burden on society. Ageing bones fail more easily when challenged mechanically or with toxicants or pollutants, and respond differently to drugs than healthy bone. To personalize therapies and enable better preventive care for the elderly it is essential to develop reliable and sustainable in vitro models of aged bone tissue alternative to animal tests which often fail to capture human-specific features. Several scientific studies support the idea that in vitro models of bone tissue are an outstanding resource for (i) the comprehension of bone physiology, (ii) a better understanding of pathological pathways in most bone dysfunctions, (iii) testing new or repurposed drugs for bone treatment before preclinical trials with animal models.The networking activities planned in OSTEONET will unravel and share knowledge on the mechanisms driving the information transfer from the biochemical and biomechanical levels, which drive osteosynthesis and osseointegration, to the cascade of molecular and cellular events emerging as an elaborated and physiological bone, and on the mechanisms of the different response of healthy and aged bone tissue to mechano-biological stimuli and drugs. Fields of science medical and health sciencesbasic medicinephysiology Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-SE-01-01 - MSCA Staff Exchanges 2021 Call for proposal HORIZON-MSCA-2021-SE-01 See other projects for this call Funding Scheme MSCA-SE - MSCA-SE Coordinator UNIVERSITA DELLA CALABRIA Net EU contribution € 239 200,00 Address Via pietro bucci 7/11/b 87036 Arcavacata di rende Italy See on map Region Sud Calabria Cosenza Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT GENT Belgium Net EU contribution € 220 800,00 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CONSORZIO DI RICERCA HYPATIA Italy Net EU contribution € 110 400,00 Address Viale i maggio 156 00046 Grottaferrata See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TEL AVIV UNIVERSITY Israel Net EU contribution € 110 400,00 Address Ramat aviv 69978 Tel aviv See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TECHNISCHE HOCHSCHULE MITTELHESSEN Germany Net EU contribution € 110 400,00 Address Wiesenstrasse 14 35390 Giessen See on map Region Hessen Gießen Gießen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ATHINA-EREVNITIKO KENTRO KAINOTOMIAS STIS TECHNOLOGIES TIS PLIROFORIAS, TON EPIKOINONION KAI TIS GNOSIS Greece Net EU contribution € 110 400,00 Address Artemidos 6 kai epidavrou 151 25 Maroussi See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CELLEX SRL Italy Net EU contribution € 220 800,00 Address Piazzale delle belle arti 2 00196 Rome See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 7HC SOCIETA A RESPONSABILITA LIMITATA Italy Net EU contribution € 110 400,00 Address Via giovanni paisello 55 00198 Roma See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ELVESYS France Net EU contribution € 13 800,00 Address 172 rue de charonne b2 2 eme etage 75011 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EFIIS SISTEMIKI VIOLOGIA MONOPROSOPI IKE Greece Net EU contribution € 110 400,00 Address Scientific park street 0 26332 Patra See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CTADVENTURE SPÓLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Poland Net EU contribution € 110 400,00 Address Ul leborska 3b 80-386 Gdansk See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Makroregion północny Pomorskie Trójmiejski Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LITHOZ GMBH Austria Net EU contribution € 0,00 Address Mollardgasse 85a 2 1 64-69 1060 Wien See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
