Periodic Reporting for period 1 - Aqua-Synapse (The health benefits of deuterium depletion on synaptic function, regional metabolism, and behaviour)
Berichtszeitraum: 2023-01-01 bis 2024-12-31
The AquaSynapse project addresses significant gaps in our understanding of deuterium-depleted water (DDW) and its potential health benefits. DDW, which contains lower levels of deuterium, has been linked to a range of health effects, including better stress response, reduced disease susceptibility, cancer prevention, and even antidepressant effects similar to pharmaceutical treatments in animal models. However, despite these promising results, the mechanisms behind these effects are not well understood, and the optimal concentrations and regimens for achieving these benefits have yet to be determined. This is especially important as DDW is already being sold in Europe with various health claims, many of which lack solid scientific backing or safety data.
AquaSynapse aims to address these uncertainties by investigating how reduced deuterium levels in drinking water affect metabolism, brain function, and behavior. The project will use advanced imaging and spectroscopy techniques to study how DDW impacts metabolic processes and brain activity at different concentrations and durations. By combining molecular, cellular, and physiological research, AquaSynapse will work to uncover the mechanisms that explain DDW's effects and determine the best ways to use it to improve health.
This research is crucial, especially considering the growing market for DDW products. While these products are promoted with claims of various health benefits, there is little rigorous scientific evidence to support many of these assertions. AquaSynapse will provide solid evidence to confirm or challenge these claims, ensuring that DDW products meet safety standards and are genuinely beneficial. The findings could lead to new ways to address stress-related conditions, metabolic disorders, and mental health issues, while also helping to shape regulatory policies for DDW and guide the development of reliable, science-backed health products, that could be commercialized.
Beyond advancing scientific knowledge, AquaSynapse will also foster collaboration across disciplines, bringing together experts in chemistry, nanotechnologies, advanced materials, pharmacology, psychiatry, and imaging. The project will offer training and development opportunities for early-stage researchers, encourage international cooperation and advance innovation in the field. Ultimately, AquaSynapse has the potential to reshape our understanding of DDW, provide a strong foundation for its health benefits, and contribute to the development of safe and effective products in the healthcare and wellness industries. This will not only benefit consumers but also support industries looking to innovate and meet the demand for scientifically validated health products.
AquaSynapse aims to address these uncertainties by investigating how reduced deuterium levels in drinking water affect metabolism, brain function, and behavior. The project will use advanced imaging and spectroscopy techniques to study how DDW impacts metabolic processes and brain activity at different concentrations and durations. By combining molecular, cellular, and physiological research, AquaSynapse will work to uncover the mechanisms that explain DDW's effects and determine the best ways to use it to improve health.
This research is crucial, especially considering the growing market for DDW products. While these products are promoted with claims of various health benefits, there is little rigorous scientific evidence to support many of these assertions. AquaSynapse will provide solid evidence to confirm or challenge these claims, ensuring that DDW products meet safety standards and are genuinely beneficial. The findings could lead to new ways to address stress-related conditions, metabolic disorders, and mental health issues, while also helping to shape regulatory policies for DDW and guide the development of reliable, science-backed health products, that could be commercialized.
Beyond advancing scientific knowledge, AquaSynapse will also foster collaboration across disciplines, bringing together experts in chemistry, nanotechnologies, advanced materials, pharmacology, psychiatry, and imaging. The project will offer training and development opportunities for early-stage researchers, encourage international cooperation and advance innovation in the field. Ultimately, AquaSynapse has the potential to reshape our understanding of DDW, provide a strong foundation for its health benefits, and contribute to the development of safe and effective products in the healthcare and wellness industries. This will not only benefit consumers but also support industries looking to innovate and meet the demand for scientifically validated health products.
28 January 2023
At the kickoff meeting, the parties agreed to use water for the research in three D concentrations, with depleted, normal, and enriched D contents. The deuterium concentration of deuterium-depleted water (DDW) was decided to be 20-25 ppm, for normal test water (NW) 145-150 ppm, and for deuterium-enriched water (DEW) 270-300 ppm.
HYD LLC started the investigational water production after the kickoff meeting. HYD LLC ordered and purchased the autoclavable glass bottles for the preparations. Due to some disturbances in the supply chain, we got access to two types of bottles, 0.5 liters, and 1 liter, in limited amounts, these types were purchased and used for production.
As a first step, the DDW-producing facility was sanitized. Afterward, the production process started without any separation by the boiling point, and NW was collected. D concentration of NW was measured and documented. The produced (NW) water was divided into two parts. One part was bottled, and the other was used for the enrichment of D adding heavy water in the proper amount and bottling. D concentration of DEW was measured and documented. The production of deuterium-depleted water (DDW) started according to the validated protocol. The D concentration of DDW was measured and documented and DDW was bottled. All three types of test waters were autoclaved at 120 oC. Samples were taken from the final products and their D concentrations were measured. The D concentration of DDW was 23 ± 2 ppm, that of NW 145 ppm ± 2 ppm, and DEW was 270 ± 2 ppm. The production was documented, and the bottles of the test waters were labeled.
DDW, NW, and DEW investigational products are ready for shipping.
At the kickoff meeting, the parties agreed to use water for the research in three D concentrations, with depleted, normal, and enriched D contents. The deuterium concentration of deuterium-depleted water (DDW) was decided to be 20-25 ppm, for normal test water (NW) 145-150 ppm, and for deuterium-enriched water (DEW) 270-300 ppm.
HYD LLC started the investigational water production after the kickoff meeting. HYD LLC ordered and purchased the autoclavable glass bottles for the preparations. Due to some disturbances in the supply chain, we got access to two types of bottles, 0.5 liters, and 1 liter, in limited amounts, these types were purchased and used for production.
As a first step, the DDW-producing facility was sanitized. Afterward, the production process started without any separation by the boiling point, and NW was collected. D concentration of NW was measured and documented. The produced (NW) water was divided into two parts. One part was bottled, and the other was used for the enrichment of D adding heavy water in the proper amount and bottling. D concentration of DEW was measured and documented. The production of deuterium-depleted water (DDW) started according to the validated protocol. The D concentration of DDW was measured and documented and DDW was bottled. All three types of test waters were autoclaved at 120 oC. Samples were taken from the final products and their D concentrations were measured. The D concentration of DDW was 23 ± 2 ppm, that of NW 145 ppm ± 2 ppm, and DEW was 270 ± 2 ppm. The production was documented, and the bottles of the test waters were labeled.
DDW, NW, and DEW investigational products are ready for shipping.
DDW, NW, and DEW investigational products are ready for shipping.