Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

Project Information

ADDIT-CE

Grant agreement ID: 101087124

DOI 10.3030/101087124

EC signature date 10 November 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Widening participation and spreading excellence

Total cost € 4 939 299,50

EU contribution € 4 939 299,50

Coordinated by

Masarykova univerzita
Czechia

Publications

Peer reviewed articles (4)

Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Author(s): Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Published in: Cell Reports, Issue vol. 42, no. 11, 2023, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113310

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

Author(s): Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Published in: Nature Communications, Issue vol. 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43403-y

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Author(s): Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Published in: Molecular Neurodegeneration, 2023, ISSN 1750-1326
Publisher: BMC
DOI: 10.1186/s13024-023-00620-9

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control

Author(s): Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Published in: Stem Cell Research, Issue vol. 74, 2023, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2023.103273

Conference proceedings (3)

Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide

Author(s): Krishnendu Bera, Lasorsa Alessia, Isabelle Landrieu, Jozef Hritz
Published in: Prague Protein Spring 2023, 2023, ISBN 978-80-86241-70-8
Publisher: Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, ELIXIR Czech Republic and SCIENTIFIKA

Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation

Author(s): Krishnendu Bera, Isabelle Landrieu, Jozef Hritz
Published in: Materials Structure in Chemistry, Biology, Physics and Technology, Issue vol. 29, no. 1, 2023, 2023, ISSN 1211-5894
Publisher: Czech and Slovak Crystallographic Association (CSCA)

P-89: 14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding

Author(s): Aneta Kozeleková, Lucia Ilkovičová, Radek Crha, Alena Hofrová, Jozef Hritz
Published in: European Biophysics Journal, Issue 52, pages 1–220 (2023), 2023
Publisher: Springer Nature
DOI: 10.1007/s00249-023-01668-7