Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

Informations projet

ADDIT-CE

N° de convention de subvention: 101087124

DOI

10.3030/101087124

Date de signature de la CE 10 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 4 939 299,50

Contribution de l’UE

€ 4 939 299,50

Coordonné par

Masarykova univerzita
Czechia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

Quality Plan, Ethics Requirements and Project Visual Identity, Website and Social Media

Summary of set-up related to T7.2 and T7.3.Ethics approvals from participating institutions and templates of informed consent.

Plan of the Communication Campaign

A detailed plan for the Task T5.4.

Initial Training Plan and CDE Plan

Action plan of training activities for the 1st year of the project, (planned speakers/coaches, topics/fields of trainings, trainees for internships, and outline for industrial PhD projects).Definition of CDE measures and action plan of CDE activities for the project.

Data Management Plan (1)

Data Management Plan

Detailed guidelines of the treatment of all types of data associated with the project utilising the Horizon Europe best practices on data management.

Publications

Peer reviewed articles (14)

Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Auteurs: Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Publié dans: Cell Reports, Numéro vol. 42, no. 11, 2023, 2023, ISSN 2211-1247
Éditeur: Amsterdam Elsevier
DOI: 10.1016/J.CELREP.2023.113310

Effects of a 4‐Month Supervised Aerobic‐Strength Training on Cognitive Functions and Clinical State of Patients with Parkinson’s Disease

Auteurs: Jozef Ukropec, Lucia Slobodová, Karin Marček Malenovská, Ali Amiri, Michaela Konečná, Igor Straka, Radka Klepochová, Zuzana Košutzká, Martin Krššák, Peter Valkovič, Barbara Ukropcová
Publié dans: Alzheimer's & Dementia, Numéro 20, 2025, ISSN 1552-5260
Éditeur: Wiley
DOI: 10.1002/ALZ.089825

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Auteurs: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Publié dans: The FEBS Journal, 2025, ISSN 1742-464X
Éditeur: Wiley
DOI: 10.1111/FEBS.17405

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

Auteurs: Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Publié dans: Nature Communications, Numéro vol. 14, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/S41467-023-43403-Y

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Auteurs: Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Publié dans: Molecular Neurodegeneration, 2023, ISSN 1750-1326
Éditeur: BMC
DOI: 10.1186/S13024-023-00620-9

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Auteurs: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Publié dans: Frontiers in Aging Neuroscience, Numéro 16, 2024, ISSN 1663-4365
Éditeur: Frontiers Media SA
DOI: 10.3389/FNAGI.2024.1468602

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Auteurs: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Publié dans: Angewandte Chemie International Edition, Numéro 63, 2024, ISSN 1433-7851
Éditeur: Wiley
DOI: 10.1002/ANIE.202407821

A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single‐cell suspension

Auteurs: Mario Kandra, Tereza Vanova, Vincent A. Jongen, Jakub Pospíšil, Josef Novák, Václav Chochola, Tomáš Buryška, Zbyněk Prokop, Zdeněk Hodný, Ales Hampl, Dasa Bohaciakova, Josef Jaros
Publié dans: Biotechnology Journal, Numéro 19, 2024, ISSN 1860-6768
Éditeur: Wiley
DOI: 10.1002/BIOT.202400240

Shaping the Future of Preclinical Development of Successful Disease- Modifying Drugs Against Alzheimer's Disease – A Systematic Review of Tau Propagation Models

Auteurs: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publié dans: Acta Neuropathologica Communications, Numéro vol. 12, 2024, ISSN 2051-5960
Éditeur: Springer Nature
DOI: 10.1186/S40478-024-01748-5

Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues

Auteurs: Gao, Tadeja; Damborsky, Jiri; Janin, Yves L.; Marek, Martin
Publié dans: ChemCatChem, Numéro 2023, 15 (19), 2023, ISSN 1867-3899
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/cctc.202300745

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Auteurs: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Publié dans: International Journal of Biological Macromolecules, Numéro Volume 266, Part 2, 2024, ISSN 0141-8130
Éditeur: Elsevier B.V.
DOI: 10.1016/J.IJBIOMAC.2024.130802

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Auteurs: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS252313049

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control

Auteurs: Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Publié dans: Stem Cell Research, Numéro vol. 74, 2023, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/J.SCR.2023.103273

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Auteurs: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Publié dans: International Journal of Biological Macromolecules, 2025, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/J.IJBIOMAC.2025.141253