Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

Publications

Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Auteurs: Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Publié dans: Cell Reports, Numéro vol. 42, no. 11, 2023, 2023, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.113310

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

Auteurs: Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Publié dans: Nature Communications, Numéro vol. 14, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-43403-y

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Auteurs: Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Publié dans: Molecular Neurodegeneration, 2023, ISSN 1750-1326
Éditeur: BMC
DOI: 10.1186/s13024-023-00620-9

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control

Auteurs: Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Publié dans: Stem Cell Research, Numéro vol. 74, 2023, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2023.103273

Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide

Auteurs: Krishnendu Bera, Lasorsa Alessia, Isabelle Landrieu, Jozef Hritz
Publié dans: Prague Protein Spring 2023, 2023, ISBN 978-80-86241-70-8
Éditeur: Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, ELIXIR Czech Republic and SCIENTIFIKA

Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation

Auteurs: Krishnendu Bera, Isabelle Landrieu, Jozef Hritz
Publié dans: Materials Structure in Chemistry, Biology, Physics and Technology, Numéro vol. 29, no. 1, 2023, 2023, ISSN 1211-5894
Éditeur: Czech and Slovak Crystallographic Association (CSCA)

P-89: 14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding

Auteurs: Aneta Kozeleková, Lucia Ilkovičová, Radek Crha, Alena Hofrová, Jozef Hritz
Publié dans: European Biophysics Journal, Numéro 52, pages 1–220 (2023), 2023
Éditeur: Springer Nature
DOI: 10.1007/s00249-023-01668-7

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