Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

Información del proyecto

ADDIT-CE

Identificador del acuerdo de subvención: 101087124

DOI

10.3030/101087124

Fecha de la firma de la CE 10 Noviembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 4 939 299,50

Aportación de la UE

€ 4 939 299,50

Coordinado por

Masarykova univerzita
Czechia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Quality Plan, Ethics Requirements and Project Visual Identity, Website and Social Media

Summary of set-up related to T7.2 and T7.3.Ethics approvals from participating institutions and templates of informed consent.

Plan of the Communication Campaign

A detailed plan for the Task T5.4.

Initial Training Plan and CDE Plan

Action plan of training activities for the 1st year of the project, (planned speakers/coaches, topics/fields of trainings, trainees for internships, and outline for industrial PhD projects).Definition of CDE measures and action plan of CDE activities for the project.

Data Management Plan (1)

Data Management Plan

Detailed guidelines of the treatment of all types of data associated with the project utilising the Horizon Europe best practices on data management.

Publicaciones

Peer reviewed articles (14)

Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Autores: Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Publicado en: Cell Reports, Edición vol. 42, no. 11, 2023, 2023, ISSN 2211-1247
Editor: Amsterdam Elsevier
DOI: 10.1016/J.CELREP.2023.113310

Effects of a 4‐Month Supervised Aerobic‐Strength Training on Cognitive Functions and Clinical State of Patients with Parkinson’s Disease

Autores: Jozef Ukropec, Lucia Slobodová, Karin Marček Malenovská, Ali Amiri, Michaela Konečná, Igor Straka, Radka Klepochová, Zuzana Košutzká, Martin Krššák, Peter Valkovič, Barbara Ukropcová
Publicado en: Alzheimer's & Dementia, Edición 20, 2025, ISSN 1552-5260
Editor: Wiley
DOI: 10.1002/ALZ.089825

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Autores: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Publicado en: The FEBS Journal, 2025, ISSN 1742-464X
Editor: Wiley
DOI: 10.1111/FEBS.17405

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

Autores: Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Publicado en: Nature Communications, Edición vol. 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/S41467-023-43403-Y

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Autores: Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Publicado en: Molecular Neurodegeneration, 2023, ISSN 1750-1326
Editor: BMC
DOI: 10.1186/S13024-023-00620-9

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Autores: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Publicado en: Frontiers in Aging Neuroscience, Edición 16, 2024, ISSN 1663-4365
Editor: Frontiers Media SA
DOI: 10.3389/FNAGI.2024.1468602

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Autores: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Publicado en: Angewandte Chemie International Edition, Edición 63, 2024, ISSN 1433-7851
Editor: Wiley
DOI: 10.1002/ANIE.202407821

A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single‐cell suspension

Autores: Mario Kandra, Tereza Vanova, Vincent A. Jongen, Jakub Pospíšil, Josef Novák, Václav Chochola, Tomáš Buryška, Zbyněk Prokop, Zdeněk Hodný, Ales Hampl, Dasa Bohaciakova, Josef Jaros
Publicado en: Biotechnology Journal, Edición 19, 2024, ISSN 1860-6768
Editor: Wiley
DOI: 10.1002/BIOT.202400240

Shaping the Future of Preclinical Development of Successful Disease- Modifying Drugs Against Alzheimer's Disease – A Systematic Review of Tau Propagation Models

Autores: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publicado en: Acta Neuropathologica Communications, Edición vol. 12, 2024, ISSN 2051-5960
Editor: Springer Nature
DOI: 10.1186/S40478-024-01748-5

Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues

Autores: Gao, Tadeja; Damborsky, Jiri; Janin, Yves L.; Marek, Martin
Publicado en: ChemCatChem, Edición 2023, 15 (19), 2023, ISSN 1867-3899
Editor: Wiley-VCH GmbH
DOI: 10.1002/cctc.202300745

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Autores: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Publicado en: International Journal of Biological Macromolecules, Edición Volume 266, Part 2, 2024, ISSN 0141-8130
Editor: Elsevier B.V.
DOI: 10.1016/J.IJBIOMAC.2024.130802

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Autores: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS252313049

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control

Autores: Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Publicado en: Stem Cell Research, Edición vol. 74, 2023, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/J.SCR.2023.103273

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Autores: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Publicado en: International Journal of Biological Macromolecules, 2025, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/J.IJBIOMAC.2025.141253