Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

Información del proyecto

ADDIT-CE

Identificador del acuerdo de subvención: 101087124

DOI 10.3030/101087124

Fecha de la firma de la CE 10 Noviembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total € 4 939 299,50

Aportación de la UE € 4 939 299,50

Coordinado por

Masarykova univerzita
Czechia

Publicaciones

Peer reviewed articles (4)

Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Autores: Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Publicado en: Cell Reports, Edición vol. 42, no. 11, 2023, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.113310

Illuminating the mechanism and allosteric behavior of NanoLuc luciferase

Autores: Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Publicado en: Nature Communications, Edición vol. 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-43403-y

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Autores: Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Publicado en: Molecular Neurodegeneration, 2023, ISSN 1750-1326
Editor: BMC
DOI: 10.1186/s13024-023-00620-9

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control

Autores: Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Publicado en: Stem Cell Research, Edición vol. 74, 2023, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2023.103273

Conference proceedings (3)

Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide

Autores: Krishnendu Bera, Lasorsa Alessia, Isabelle Landrieu, Jozef Hritz
Publicado en: Prague Protein Spring 2023, 2023, ISBN 978-80-86241-70-8
Editor: Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, ELIXIR Czech Republic and SCIENTIFIKA

Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation

Autores: Krishnendu Bera, Isabelle Landrieu, Jozef Hritz
Publicado en: Materials Structure in Chemistry, Biology, Physics and Technology, Edición vol. 29, no. 1, 2023, 2023, ISSN 1211-5894
Editor: Czech and Slovak Crystallographic Association (CSCA)

P-89: 14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding

Autores: Aneta Kozeleková, Lucia Ilkovičová, Radek Crha, Alena Hofrová, Jozef Hritz
Publicado en: European Biophysics Journal, Edición 52, pages 1–220 (2023), 2023
Editor: Springer Nature
DOI: 10.1007/s00249-023-01668-7