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Deciphering the neonatal shift in neurovascular coupling: a multimodal approach

Project description

Neuronal-vascular association in neonates

The brain regulates its own blood flow to meet the high metabolic and energy demands through a mechanism known as neurovascular coupling. Blood oxygenation level-dependent (BOLD) technique is a non-invasive method used to measure brain activity by quantifying the changes in tissue oxygenation and blood flow. Studies in newborns using BOLD indicate an unexplained variation, potentially offering an avenue for better understanding of brain development and haemodynamics. The EU-funded 2BOLD project aims to resolve spatiotemporal changes in haemodynamics during brain development to understand neurovascular coupling. Using a mouse model, researchers will combine haemodynamic and vascular data alongside metabolic activity measurements to decipher the mechanism.


Net EU contribution
€ 172 618,56
Paco Das Escolas
3004-531 Coimbra

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Continente Centro (PT) Região de Coimbra
Activity type
Higher or Secondary Education Establishments
Other funding
No data