Descripción del proyecto
Mejora de la eficacia de los nanogeles inhalables para el tratamiento de los carcinomas broncopulmonares
Los nanogeles son sistemas portadores de fármacos prometedores que pueden administrar medicamentos en células específicas del organismo. Recientemente, su versatilidad se ha demostrado en el tratamiento de trastornos y enfermedades, incluido el cáncer. La administración de fármacos en los pulmones mediante nanogeles inhalables se considera beneficiosa para el tratamiento de carcinomas broncopulmonares, pero es necesario superar varios escollos antes de generalizar su uso. El objetivo del proyecto PuDeRegels, financiado con fondos europeos, es mejorar la eficacia de los nanogeles para que puedan administrar fármacos antineoplásicos de forma segura y precisa en los pulmones a través del aparato respiratorio. El equipo de PuDeRegels, que combina conocimientos especializado en la ciencia de polímeros y la biología química, se propone superar los escollos relacionados con la encapsulación de fármacos antineoplásicos, la administración dirigida, la liberación de fármacos, la biocompatibilidad y la evasión de macrófagos.
Objetivo
In this project, I will investigate and develop nanogels incorporated into microgels containing encapsulated anticancer drugs. These nanogels will be delivered via the respiratory system to the lung, selectively swell and deliberate the therapeutic. Importance will be given to targeting moieties, stealth moieties, and biocompatibility. The delivery of drugs for lung cancer is limited but is under investigation and on the rise of inquiry. Some of the challenges this type of technology faces are the efficient encapsulation of the bioactive compound inside a nanocarrier, the targeted delivery, the release of the drug, the biocompatibility with the lung, and the avoidance of the macrophages. New methodologies for better delivery of therapeutics are of great importance at the National and International levels. New materials and technologies are emerging every year. The delivery of therapeutics for lung cancer is based mainly on intravenous therapies. Another way of introducing drugs into the area of importance in the lung could be pulmonary drug delivery as a good alternative. Pulmonary delivery is not a new technology but is strictly limited to specific conditions/illnesses. The research capitalizes on the existing strengths of the experienced researcher (ER) in polymer science and the expertise of the host institute in chemical biology in health, drug research, and biotechnology. It will lead to several publications in high-impact factor journals, transfer of knowledge and expertise that could be capitalized at an industrial level, thus contributing to the research output, distinctness, and economy of Europe. Overall, the fellowship will allow the ER to reintegrate into a long-term academic position after many years of fruitful research career in the academic sector in Spain. After this project, the ER will obtain new knowledge and training that will help him to establish a solid point for a better opportunity both in Academy and in Industry.
Ámbito científico
Programa(s)
Convocatoria de propuestas
HORIZON-WIDERA-2022-TALENTS-02
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-AG-UN - HORIZON Unit GrantCoordinador
11635 Athina
Grecia