Electrified Liquid-Liquid Interfaces Supported in 3D Printed Platforms for Rapid Detection of Benzodiazepine Date Rape Drugs

Descripción del proyecto

Detección inmediata de drogas utilizadas para violar

Las benzodiacepinas son fármacos sedantes que actúan sobre el sistema nervioso central para ralentizar las funciones corporales y encefálicas. Aunque su uso está muy extendido para tratar la ansiedad y el insomnio, se han producido casos en que se han utilizado con fines de agresión sexual para incapacitar a otra persona. El equipo del proyecto e-gainstRapeDrugs, financiado con fondos europeos, pretende desarrollar un sensor de detección de benzodiacepinas para prevenir delitos sociales. Los investigadores aprovecharán la impresión tridimensional para generar sensores y realizar análisis exhaustivos de las especies moleculares de fármacos que se detecten. El producto obtenido puede ser utilizado fácilmente por cualquier persona para detectar drogas benzodiacepínicas al instante.

Objetivo

The main objective of this work is to develop simple sensing solutions for benzodiazepines (BDZ, date rape drugs) detection. The outcomes of this project are expected to be visible to citizens as the fully functional sensing solutions. Proposed innovation is a resultant of three main streams: (i) 3D printing for the sensors development, (ii) comprehensive electroanalysis of BDZs at the electrified liquid-liquid interface (eLLI), and (iii) very meticulous electroanalytical screening focused on BDZ and co-existing interfering species (defined based on target real samples). BDZ are psychoactive species renowned for their ability to induce sedation, aid sleep and are prescribed to treat a range of clinical conditions (e.g. anxiety). Some BDZs and their structural analogues are classified as illicit drugs and are subjected to strict control. The combination of BDZ and alcohol was mostly related to drug-facilitated crimes such as sexual assaults. Due to related health and economic issues caused by BDZs it is necessary to strengthen their on-the-spot detection. This project will develop eLLI based analytical tools to evade BDZ related social crimes and health hazards. 3D printing will be used to create sensing platforms that can be utilized on the spot. Further, the solutions proposed in this proposal are expected to be fully applicable for the presumptive analysis of BDZ drugs by non-expects and possess commercial opportunities for widespread adoption. The adviser and the researcher bring complimentary experience in the domains of eLLI and electrochemical sensors. Moreover, the goal of this project is to enhance the innovative potential of researcher who wish to acquire new skills through advanced training, mobility, new environment, and who is seeking to continue his career in research. MSCA guidelines on supervision Will be followed to foster soft and hard skills of researcher, willing to contribute to solving the challenges defined by the MSCA Green Charter.