GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION

Project Information

GlycanTrigger

Grant agreement ID: 101093997

DOI

10.3030/101093997

EC signature date 5 December 2022

Start date 1 January 2023

End date 31 December 2028

Funded under

• Health

Total cost

€ 6 771 571,00

EU contribution

€ 6 771 571,00

Coordinated by

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website

Data Management Plan (1)

Development and update of the Data Management Plan 1

Documents, reports (3)

Risk assessment analysis
Definition of the gut glycome map along health to inflammation transition.
Dissemination, Communication & Exploitation Plan 1

Publications

Peer reviewed articles (11)

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Author(s): Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Man
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/S41423-023-01052-7

Immunoglobulin A Glycosylation Differs between Crohn’s Disease and Ulcerative Colitis

Author(s): Florent Clerc; Karli R. Reiding; Noortje de Haan; Carolien A. M. Koeleman; Agnes L. Hipgrave Ederveen; Natalia Manetti; Viktoria Dotz; Vito Annese; Manfred Wuhrer
Published in: Journal of Proteome Research, 2023, ISSN 1535-3907
Publisher: American Chemical Society
DOI: 10.1021/ACS.JPROTEOME.3C00260

Nutrition Journal

Author(s): Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana S.; Motta, Carla Motta; Barreto, Gonçalo; Eklund, Kari K.; Alnso‑Pérez, Ana; Gómez, Rodolfo; Cicc, Francesco; Mauro, Daniele; Pinho, Salomé S.; Fonseca, João Eurico; Costa Reis, Patricia; Guerreiro, Catarina Sousa
Published in: Nutrition Journal, 2025, ISSN 1475-2891
Publisher: London : BioMed Central
DOI: 10.1186/S12937-025-01089-6

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Author(s): Lucy I. Crouch, Cláudia S. Rodrigues, Cassie R. Bakshani, Leticia Tavares-Gomes, Joana Gaifem, Salomé S. Pinho
Published in: Seminars in Immunology, Issue 73, 2024, ISSN 1044-5323
Publisher: Elsevier BV
DOI: 10.1016/j.smim.2024.101891

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Author(s): Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Published in: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Publisher: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

Gut Microbes

Author(s): Cláudia S. Rodrigues; Joana Gaifem; Márcia S. Pereira; Maria Francisca Alves; Mariana Silva; Nuno Padrão; Bruno Cavadas; Catarina Moreira-Barbosa; Inês Alves; Ricardo Marcos-Pinto; Joana Torres; Aonghus Lavelle; Jean-Frederic Colombel; Harry Sokol; Salomé S. Pinho
Published in: Gut Microbes, 2025, ISSN 1949-0976
Publisher: Taylor & Francis
DOI: 10.1080/19490976.2025.2461210

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Author(s): Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Published in: Carbohydrate Research, Issue 544, 2024, ISSN 0008-6215
Publisher: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Nature Immunology

Author(s): Joana Gaifem; Cláudia S. Rodrigues; Francesca Petralia; Inês Alves; Eduarda Leite-Gomes; Bruno Cavadas; Ana M. Dias; Catarina Moreira-Barbosa; Joana Revés; Renee M. Laird; Mislav Novokmet; Jerko Štambuk; Siniša Habazin; Berk Turhan; Zeynep H. Gümüş; Ryan Ungaro; Joana Torres; Gordan Lauc; Jean-Frederic Colombel; Chad K. Porter; Salomé S. Pinho
Published in: Nature Immunology, 2024, ISSN 1529-2908
Publisher: Nature Portfolio
DOI: 10.1038/s41590-024-01916-8

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Author(s): Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Publisher: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Author(s): Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/J.IT.2023.06.004

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Author(s): Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1