GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION

Project Information

GlycanTrigger

Grant agreement ID: 101093997

DOI

10.3030/101093997

EC signature date 5 December 2022

Start date 1 January 2023

End date 31 December 2028

Funded under

• Health

Total cost

€ 6 771 571,00

EU contribution

€ 6 771 571,00

Coordinated by

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website

Data Management Plan (1)

Development and update of the Data Management Plan 1

Documents, reports (3)

Risk assessment analysis
Definition of the gut glycome map along health to inflammation transition.
Dissemination, Communication & Exploitation Plan 1

Publications

Peer reviewed articles (13)

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Author(s): Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Man
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/S41423-023-01052-7

Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation

Author(s): Rodrigues, C. S., Gaifem, J., Pereira, M. S., Alves, M. F., Silva, M., Padrão, N., Cavadas, B., Moreira-Barbosa, C., Alves, I., Marcos-Pinto, R., Torres, J., Lavelle, A., Colombel, J. F., Sokol, H., & Pinho, S. S.
Published in: Gut Microbes, 2025, ISSN 1949-0984
Publisher: Austin, Tex. : Landes Bioscience
DOI: 10.1080/19490976.2025.2461210

TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis

Author(s): Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K. Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S. Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro
Published in: Nutrition Journal, Issue 24, 2025, ISSN 1475-2891
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12937-025-01089-6

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

Author(s): Roodline Cineus, Yanjiang Luo, Mariia Saliutina, Subhakankha Manna, Camila A. Cancino, Luis Velasco Blázquez, Lifen Wang, Diana Bösel, Aya Abdelrahman, Joanna E. Klementowicz, Alexis Scherl, Saskia Hainbuch, Béatrice Bréart, Gino Kwon, Agata Konopka, Gabriela M. Guerra, Elena von Coburg, Lorenz Gerbeth, Juliette Roels, Frederik Heinrich, Nils Müller, Pawel Durek, Nikolaus Deigendesch, James Ziai, Jeffrey Hung, Thomas Conrad, null null, Imke Atreya, Raja Atreya, Petra Bacher, Christoph Becker, Christian Bojarski, Nathalie Britzen-Laurent, Caroline Bosch-Voskens, Hyun-Dong Chang, Andreas Diefenbach, Claudia Günther, Ahmed N. Hegazy, Kai Hildner, Christoph S. N. Klose, Kristina Koop, Susanne Krug, Moritz Leppkes, Rocío López-Posadas, Leif S.-H. Ludwig, Clemens Neufert, Markus Neurath, Jay Patankar, Magdalena Prüß, Andreas Radbruch, Francesca Ronchi, Ashley Sanders, Alexander Scheffold, Jörg-Dieter Schulzke, Sebastian Schürmann, Michael Stürzl, Zlatko Trajanoski, Antigoni Triantafyllopoulou, Maximilian Waldner, Carl Weidinger, Sebastian Zundler, Anja A. Kühl, Stefan Wirtz, Max Löhning, Mary Keir, Andreas Diefenbach, Mir-Farzin Mashreghi, Britta Siegmund, Michael Schumann, Chiara Romagnani, Nathaniel R. West, Ahmed N. Hegazy
Published in: Nature Immunology, Issue 26, 2025, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02149-Z

Immunoglobulin A Glycosylation Differs between Crohn’s Disease and Ulcerative Colitis

Author(s): Florent Clerc; Karli R. Reiding; Noortje de Haan; Carolien A. M. Koeleman; Agnes L. Hipgrave Ederveen; Natalia Manetti; Viktoria Dotz; Vito Annese; Manfred Wuhrer
Published in: Journal of Proteome Research, 2023, ISSN 1535-3907
Publisher: American Chemical Society
DOI: 10.1021/ACS.JPROTEOME.3C00260

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Author(s): Lucy I. Crouch, Cláudia S. Rodrigues, Cassie R. Bakshani, Leticia Tavares-Gomes, Joana Gaifem, Salomé S. Pinho
Published in: Seminars in Immunology, Issue 73, 2024, ISSN 1044-5323
Publisher: Elsevier BV
DOI: 10.1016/j.smim.2024.101891

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Author(s): Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Published in: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Publisher: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry

Author(s): Marina Bondareva, Lisa Budzinski, Pawel Durek, Mario Witkowski, Stefan Angermair, Justus Ninnemann, Jakob Kreye, Philine Letz, Marta Ferreira-Gomes, Iaroslav Semin, Gabriela Maria Guerra, S. Momsen Reincke, Elisa Sánchez-Sendin, Selin Yilmaz, Toni Sempert, Gitta Anne Heinz, Caroline Tizian, Martin Raftery, Günther Schönrich, Daria Matyushkina, Ivan V. Smirnov, Vadim M. Govorun, Eva Schrezenmeier, Anna-Luisa Stefanski, Thomas Dörner, Silvia Zocche, Edoardo Viviano, Nele Klement, Katharina Johanna Sehmsdorf, Alexander Lunin, Hyun-Dong Chang, Marina Drutskaya, Liubov Kozlovskaya, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Prüss, Philipp Enghard, Mir-Farzin Mashreghi, Andrey A. Kruglov
Published in: Cell Host & Microbe, Issue 31, 2024, ISSN 1931-3128
Publisher: Elsevier BV
DOI: 10.1016/J.CHOM.2023.10.007

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Author(s): Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Published in: Carbohydrate Research, Issue 544, 2024, ISSN 0008-6215
Publisher: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Author(s): Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Publisher: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Author(s): Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/J.IT.2023.06.004

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Author(s): Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

Author(s): Gaifem J, Rodrigues CS, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS.
Published in: Nature immunology, ISSN 1529-2916
Publisher: New York, NY : Nature America Inc. c2000-
DOI: 10.1038/S41590-024-01916-8

Book chapters (1)

N-Glycans as fundamental immune-checkpoints at the frontiers of inflammation, autoimmunity and cancer

Author(s): Catarina M. Azevedo; Beatriz Santos-Pereira; Eduarda Leite-Gomes; Cláudia S. Rodrigues; Carolina S. Dantas; Guilherme Faria; Rafaela Nogueira; Pedro Almeida; Letícia Tavares-Gomes; Joana Gaifem; Inês Alves; Ângela Fernandes; Salomé S. Pinho
Published in: Carbohydrate Chemistry: Chemical and Biological Approaches Volume 47
Publisher: Royal Society of Chemistry
DOI: 10.1039/9781837676101-00001