GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION

Informations projet

GlycanTrigger

N° de convention de subvention: 101093997

DOI

10.3030/101093997

Date de signature de la CE 5 Decembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2028

Financé au titre de

• Health

Coût total

€ 6 771 571,00

Contribution de l’UE

€ 6 771 571,00

Coordonné par

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project website

Data Management Plan (1)

Development and update of the Data Management Plan 1

Documents, reports (3)

Risk assessment analysis
Definition of the gut glycome map along health to inflammation transition.
Dissemination, Communication & Exploitation Plan 1

Publications

Peer reviewed articles (11)

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Auteurs: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Man
Publié dans: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Éditeur: Nature Publishing Group
DOI: 10.1038/S41423-023-01052-7

Immunoglobulin A Glycosylation Differs between Crohn’s Disease and Ulcerative Colitis

Auteurs: Florent Clerc; Karli R. Reiding; Noortje de Haan; Carolien A. M. Koeleman; Agnes L. Hipgrave Ederveen; Natalia Manetti; Viktoria Dotz; Vito Annese; Manfred Wuhrer
Publié dans: Journal of Proteome Research, 2023, ISSN 1535-3907
Éditeur: American Chemical Society
DOI: 10.1021/ACS.JPROTEOME.3C00260

Nutrition Journal

Auteurs: Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana S.; Motta, Carla Motta; Barreto, Gonçalo; Eklund, Kari K.; Alnso‑Pérez, Ana; Gómez, Rodolfo; Cicc, Francesco; Mauro, Daniele; Pinho, Salomé S.; Fonseca, João Eurico; Costa Reis, Patricia; Guerreiro, Catarina Sousa
Publié dans: Nutrition Journal, 2025, ISSN 1475-2891
Éditeur: London : BioMed Central
DOI: 10.1186/S12937-025-01089-6

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Auteurs: Lucy I. Crouch, Cláudia S. Rodrigues, Cassie R. Bakshani, Leticia Tavares-Gomes, Joana Gaifem, Salomé S. Pinho
Publié dans: Seminars in Immunology, Numéro 73, 2024, ISSN 1044-5323
Éditeur: Elsevier BV
DOI: 10.1016/j.smim.2024.101891

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Auteurs: Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Publié dans: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Éditeur: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

Gut Microbes

Auteurs: Cláudia S. Rodrigues; Joana Gaifem; Márcia S. Pereira; Maria Francisca Alves; Mariana Silva; Nuno Padrão; Bruno Cavadas; Catarina Moreira-Barbosa; Inês Alves; Ricardo Marcos-Pinto; Joana Torres; Aonghus Lavelle; Jean-Frederic Colombel; Harry Sokol; Salomé S. Pinho
Publié dans: Gut Microbes, 2025, ISSN 1949-0976
Éditeur: Taylor & Francis
DOI: 10.1080/19490976.2025.2461210

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Auteurs: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Publié dans: Carbohydrate Research, Numéro 544, 2024, ISSN 0008-6215
Éditeur: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Nature Immunology

Auteurs: Joana Gaifem; Cláudia S. Rodrigues; Francesca Petralia; Inês Alves; Eduarda Leite-Gomes; Bruno Cavadas; Ana M. Dias; Catarina Moreira-Barbosa; Joana Revés; Renee M. Laird; Mislav Novokmet; Jerko Štambuk; Siniša Habazin; Berk Turhan; Zeynep H. Gümüş; Ryan Ungaro; Joana Torres; Gordan Lauc; Jean-Frederic Colombel; Chad K. Porter; Salomé S. Pinho
Publié dans: Nature Immunology, 2024, ISSN 1529-2908
Éditeur: Nature Portfolio
DOI: 10.1038/s41590-024-01916-8

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Auteurs: Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Publié dans: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Éditeur: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Auteurs: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Publié dans: Trends in Immunology, 2023, ISSN 1471-4906
Éditeur: Elsevier BV
DOI: 10.1016/J.IT.2023.06.004

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Auteurs: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Publié dans: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Éditeur: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1