GLYCANS AS MASTER TRIGGERS OF HEALTH TO INTESTINAL INFLAMMATION TRANSITION

Informacje na temat projektu

GlycanTrigger

Identyfikator umowy o grant: 101093997

DOI

10.3030/101093997

Data podpisania przez KE 5 Grudnia 2022

Data rozpoczęcia 1 Stycznia 2023

Data zakończenia 31 Grudnia 2028

Finansowanie w ramach

• Health

Koszt całkowity

€ 6 771 571,00

Wkład UE

€ 6 771 571,00

Koordynowany przez

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Project website

Data Management Plan (1)

Development and update of the Data Management Plan 1

Documents, reports (3)

Risk assessment analysis
Definition of the gut glycome map along health to inflammation transition.
Dissemination, Communication & Exploitation Plan 1

Publikacje

Peer reviewed articles (13)

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Autorzy: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Man
Opublikowane w: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Wydawca: Nature Publishing Group
DOI: 10.1038/S41423-023-01052-7

Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation

Autorzy: Rodrigues, C. S., Gaifem, J., Pereira, M. S., Alves, M. F., Silva, M., Padrão, N., Cavadas, B., Moreira-Barbosa, C., Alves, I., Marcos-Pinto, R., Torres, J., Lavelle, A., Colombel, J. F., Sokol, H., & Pinho, S. S.
Opublikowane w: Gut Microbes, 2025, ISSN 1949-0984
Wydawca: Austin, Tex. : Landes Bioscience
DOI: 10.1080/19490976.2025.2461210

TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis

Autorzy: Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K. Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S. Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro
Opublikowane w: Nutrition Journal, Numer 24, 2025, ISSN 1475-2891
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S12937-025-01089-6

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

Autorzy: Roodline Cineus, Yanjiang Luo, Mariia Saliutina, Subhakankha Manna, Camila A. Cancino, Luis Velasco Blázquez, Lifen Wang, Diana Bösel, Aya Abdelrahman, Joanna E. Klementowicz, Alexis Scherl, Saskia Hainbuch, Béatrice Bréart, Gino Kwon, Agata Konopka, Gabriela M. Guerra, Elena von Coburg, Lorenz Gerbeth, Juliette Roels, Frederik Heinrich, Nils Müller, Pawel Durek, Nikolaus Deigendesch, James Ziai, Jeffrey Hung, Thomas Conrad, null null, Imke Atreya, Raja Atreya, Petra Bacher, Christoph Becker, Christian Bojarski, Nathalie Britzen-Laurent, Caroline Bosch-Voskens, Hyun-Dong Chang, Andreas Diefenbach, Claudia Günther, Ahmed N. Hegazy, Kai Hildner, Christoph S. N. Klose, Kristina Koop, Susanne Krug, Moritz Leppkes, Rocío López-Posadas, Leif S.-H. Ludwig, Clemens Neufert, Markus Neurath, Jay Patankar, Magdalena Prüß, Andreas Radbruch, Francesca Ronchi, Ashley Sanders, Alexander Scheffold, Jörg-Dieter Schulzke, Sebastian Schürmann, Michael Stürzl, Zlatko Trajanoski, Antigoni Triantafyllopoulou, Maximilian Waldner, Carl Weidinger, Sebastian Zundler, Anja A. Kühl, Stefan Wirtz, Max Löhning, Mary Keir, Andreas Diefenbach, Mir-Farzin Mashreghi, Britta Siegmund, Michael Schumann, Chiara Romagnani, Nathaniel R. West, Ahmed N. Hegazy
Opublikowane w: Nature Immunology, Numer 26, 2025, ISSN 1529-2908
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02149-Z

Immunoglobulin A Glycosylation Differs between Crohn’s Disease and Ulcerative Colitis

Autorzy: Florent Clerc; Karli R. Reiding; Noortje de Haan; Carolien A. M. Koeleman; Agnes L. Hipgrave Ederveen; Natalia Manetti; Viktoria Dotz; Vito Annese; Manfred Wuhrer
Opublikowane w: Journal of Proteome Research, 2023, ISSN 1535-3907
Wydawca: American Chemical Society
DOI: 10.1021/ACS.JPROTEOME.3C00260

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Autorzy: Lucy I. Crouch, Cláudia S. Rodrigues, Cassie R. Bakshani, Leticia Tavares-Gomes, Joana Gaifem, Salomé S. Pinho
Opublikowane w: Seminars in Immunology, Numer 73, 2024, ISSN 1044-5323
Wydawca: Elsevier BV
DOI: 10.1016/j.smim.2024.101891

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Autorzy: Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Opublikowane w: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Wydawca: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry

Autorzy: Marina Bondareva, Lisa Budzinski, Pawel Durek, Mario Witkowski, Stefan Angermair, Justus Ninnemann, Jakob Kreye, Philine Letz, Marta Ferreira-Gomes, Iaroslav Semin, Gabriela Maria Guerra, S. Momsen Reincke, Elisa Sánchez-Sendin, Selin Yilmaz, Toni Sempert, Gitta Anne Heinz, Caroline Tizian, Martin Raftery, Günther Schönrich, Daria Matyushkina, Ivan V. Smirnov, Vadim M. Govorun, Eva Schrezenmeier, Anna-Luisa Stefanski, Thomas Dörner, Silvia Zocche, Edoardo Viviano, Nele Klement, Katharina Johanna Sehmsdorf, Alexander Lunin, Hyun-Dong Chang, Marina Drutskaya, Liubov Kozlovskaya, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Prüss, Philipp Enghard, Mir-Farzin Mashreghi, Andrey A. Kruglov
Opublikowane w: Cell Host & Microbe, Numer 31, 2024, ISSN 1931-3128
Wydawca: Elsevier BV
DOI: 10.1016/J.CHOM.2023.10.007

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Autorzy: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Opublikowane w: Carbohydrate Research, Numer 544, 2024, ISSN 0008-6215
Wydawca: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Autorzy: Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Opublikowane w: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Wydawca: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Autorzy: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Opublikowane w: Trends in Immunology, 2023, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/J.IT.2023.06.004

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Autorzy: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Opublikowane w: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Wydawca: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

Autorzy: Gaifem J, Rodrigues CS, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS.
Opublikowane w: Nature immunology, ISSN 1529-2916
Wydawca: New York, NY : Nature America Inc. c2000-
DOI: 10.1038/S41590-024-01916-8

Book chapters (1)

N-Glycans as fundamental immune-checkpoints at the frontiers of inflammation, autoimmunity and cancer

Autorzy: Catarina M. Azevedo; Beatriz Santos-Pereira; Eduarda Leite-Gomes; Cláudia S. Rodrigues; Carolina S. Dantas; Guilherme Faria; Rafaela Nogueira; Pedro Almeida; Letícia Tavares-Gomes; Joana Gaifem; Inês Alves; Ângela Fernandes; Salomé S. Pinho
Opublikowane w: Carbohydrate Chemistry: Chemical and Biological Approaches Volume 47
Wydawca: Royal Society of Chemistry
DOI: 10.1039/9781837676101-00001