Inflammation in human early life: targeting impacts on life-course health

Project Information

INITIALISE

Grant agreement ID: 101094099

DOI

10.3030/101094099

EC signature date 24 November 2022

Start date 1 January 2023

End date 31 December 2028

Funded under

• Health

Total cost

€ 7 451 043,75

EU contribution

€ 7 451 043,75

Coordinated by

TURUN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website and corporate design completed

Project website and corporate design completed.

Documents, reports (1)

Report on data already available from INITIALISE cohorts, including analytical platforms used

Report on data already available from INITIALISE cohorts, including analytical platforms used.

Publications

Peer reviewed articles (21)

Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads

Author(s): Manuel Bernabeu, Elena Cabello-Yeves, Eduard Flores, Anna Samarra, Joanna Kimberley Summers, Alberto Marina, M Carmen Collado
Published in: Current Opinion in Microbiology, ISSN 1879-0364
Publisher: Elsevier
DOI: 10.1016/J.MIB.2023.102424

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization

Author(s): H Isokääntä, L Pinto da Silva, N Karu, T Kallonen, A-K Aatsinki, T Hankemeier, L Schimmel, E Diaz, T Hyötyläinen, P C Dorrestein, R Knight, M Orešič, R Kaddurah-Daouk, A M Dickens, S Lamichhane
Published in: Analytical Chemistry, ISSN 1520-6882
Publisher: ACS publications
DOI: 10.1021/ACS.ANALCHEM.3C04436

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Author(s): Partho Sen; Matej Orešič
Published in: Metabolites, 2023, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo13070855

Nutrients

Author(s): Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Published in: Nutrients, ISSN 2072-6643
Publisher: MDPI
DOI: 10.3390/NU16111708

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Author(s): Santosh Lamichhane; Taina Härkönen; Tommi Vatanen; Tuulia Hyötyläinen; Mikael Knip; Matej Orešič
Published in: Environment international, 2023, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1101/2022.12.14.22283359

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Author(s): Lamichhane Santosh , Sen Partho , Dickens Alex M. , Kråkström Matilda , Ilonen Jorma , Lempainen Johanna , Hyöty Heikki , Lahesmaa Riitta , Veijola Riitta , Toppari Jorma , Hyötyläinen Tuulia , Knip Mikael , Orešič Matej
Published in: Frontiers in endocrinology, ISSN 1664-2392
Publisher: frontiers
DOI: 10.3389/FENDO.2023.1211015

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study Author links

Author(s): Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
Published in: The Lancet Planetary Health, 2024, ISSN 2542-5196
Publisher: Elsevier
DOI: 10.1016/S2542-5196(23)00257-7

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Author(s): Sergio Andreu-Sánchez, Arno R. Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Angel J. Ruiz-Moreno, Shixian Hu, Trishla Sinha, Arnau Vich Vila, Shelley Klompus, Iris N. Kalka, Karina de Leeuw, Suzanne Arends, Iris Jonkers, Sebo Withoff, El
Published in: Immunity, ISSN 1074-7613
Publisher: Elsevier
DOI: 10.1016/J.IMMUNI.2023.04.003

Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

Author(s): Bruzzaniti S, Piemonte E, Bruzzese D, Lepore MT, Strollo R, Izzo L, Di Candia F, Franzese A, Bifulco M, Mozzillo E, Ludvigsson J, Matarese G, Galgani M
Published in: Diabetologia, ISSN 1432-0428
Publisher: Springer
DOI: 10.1007/S00125-023-06075-3

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Author(s): Fernández-Pato A, Sinha T, Gacesa R, Andreu-Sánchez S, Gois MFB, Gelderloos-Arends J, Jansen DBH, Kruk M, Jaeger M, Joosten LAB, Netea MG, Weersma RK, Wijmenga C, Harmsen HJM, Fu J, Zhernakova A, Kurilshikov A
Published in: Scientific Reports, ISSN 2045-2322
Publisher: Nature
DOI: 10.1038/S41598-024-54353-W

Recent advances towards mass spectrometry-based clinical lipidomics

Author(s): Samira Salihovic, Santosh Lamichane, Tuulia Hyötyläinen, Matej Orešič
Published in: Current Opinion in Chemical Biology, 2023, ISSN 1367-5931
Publisher: Elsevier
DOI: 10.1016/J.CBPA.2023.102370

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Author(s): Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Published in: Immunity, Issue VOLUME=56;ISSUE=6;STARTPAGE=1;ENDPAGE=17;ISSN=1074-7613, 2023, ISSN 1074-7613
Publisher: Elsevier
DOI: 10.1016/j.immuni.2023.04.017

Infant microbes and metabolites point to childhood neurodevelopmental disorders

Author(s): Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Published in: Cell, ISSN 1097-4172
Publisher: Elsevier
DOI: 10.1016/J.CELL.2024.02.035

The maternal gut microbiome in pregnancy: implications for the developing immune system

Author(s): Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar & Maria Carmen Collado
Published in: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5053
Publisher: nature
DOI: 10.1038/S41575-023-00864-2

Host genetic regulation of human gut microbial structural variation

Author(s): Daria V. Zhernakova, Daoming Wang, Lei Liu, Sergio Andreu-Sánchez, Yue Zhang, Angel J. Ruiz-Moreno, Haoran Peng, Niels Plomp, Ángela Del Castillo-Izquierdo, Ranko Gacesa, Esteban A. Lopera-Maya, Godfrey S. Temba, Vesla I. Kullaya, Sander S. van Leeuwen, L
Published in: nature, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/S41586-023-06893-W

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Author(s): Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke
Published in: Genome Biology, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/S13059-023-03151-0

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Author(s): Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis

Author(s): Gianmarco Abbadessa, Maria Teresa Lepore, Sara Bruzzaniti, Erica Piemont, Giuseppina Miele, Elisabetta Signoriello, Francesco Perna, Chiara De Falco, G. Lus, Giuseppe Matarese, Simona Bonavita, Mario Galgani
Published in: Neurology: neuroimmunology and neuroinflammation, ISSN 2332-7812
Publisher: American Academy of Neurology
DOI: 10.1212/NXI.0000000000200250

Nature Communications

Author(s): Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, Lifelines NEXT cohort study, Jackie Dekens, Jan Sikkema, Folkert Kuipers, And
Published in: Nature Communications, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-45257-4

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

Author(s): Bagavathy Shanmugam Karthikeyan, Tuulia Hyötyläinen, Tannaz Ghaffarzadegan, Eric Triplett, Matej Orešič, Johnny Ludvigsson
Published in: Journal of Exposure Science & Environmental Epidemiology, ISSN 1559-064X
Publisher: Springer Nature
DOI: 10.1038/S41370-024-00680-Z

The influence of pre- and postnatal exposure to air pollution and green spaces on infant’s gut microbiota: Results from the MAMI birth cohort study

Author(s): Adrià Cruells, Raúl Cabrera-Rubio, Mariona Bustamante, Dolors Pelegrí , Marta Cirach, Pol Jimenez-Arenas, Anna Samarra, Cecilia Martínez-Costa, Maria Carmen Collado, Mireia Gascon
Published in: Environmental Research, ISSN 1096-0953
Publisher: Elsevier
DOI: 10.1016/J.ENVRES.2024.119283