Inflammation in human early life: targeting impacts on life-course health

Project Information

INITIALISE

Grant agreement ID: 101094099

DOI

10.3030/101094099

EC signature date 24 November 2022

Start date 1 January 2023

End date 31 December 2028

Funded under

• Health

Total cost

€ 7 451 043,75

EU contribution

€ 7 451 043,75

Coordinated by

TURUN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website and corporate design completed

Project website and corporate design completed.

Documents, reports (1)

Report on data already available from INITIALISE cohorts, including analytical platforms used

Report on data already available from INITIALISE cohorts, including analytical platforms used.

Publications

Peer reviewed articles (53)

Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads

Author(s): Manuel Bernabeu, Elena Cabello-Yeves, Eduard Flores, Anna Samarra, Joanna Kimberley Summers, Alberto Marina, M Carmen Collado
Published in: Current Opinion in Microbiology, ISSN 1879-0364
Publisher: Elsevier
DOI: 10.1016/J.MIB.2023.102424

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Author(s): Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Published in: Allergy, 2026, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.70218

FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

Author(s): Camille Bédard, Alicia Pageau, Anna Fijarczyk, David Mendoza-Salido, Alejandro J. Alcañiz, Philippe C. Després, Romain Durand, Samuel Plante, Emilie M. M. Alexander, François D. Rouleau, David F. Jordan, Adarsh Jay, Mathieu Giguère, Mégane Bernier, Jehoshua Sharma, Laetitia Maroc, Nicholas C. Gervais, Anagha C. T. Menon, Isabelle Gagnon-Arsenault, Sibbe Bakker, Johanna Rhodes, Philippe J. Dufresne, Amrita Bharat, Adnane Sellam, Domenica G. De Luca, Aleeza Gerstein, Rebecca S. Shapiro, Narciso M. Quijada, Christian R. Landry
Published in: Nature Microbiology, Issue 10, 2025, ISSN 2058-5276
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41564-025-02084-7

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Author(s): Trishla Sinha, Jelmer R. Prins, Asier Fernández-Pato, Marloes Kruk, Thomas Dierikx, Tim de Meij, Marjon de Boer, Jan Freark de Boer, Sicco Scherjon, Alexander Kurilshikov, Alexandra Zhernakova
Published in: Cell Host & Microbe, Issue 32, 2025, ISSN 1931-3128
Publisher: Elsevier BV
DOI: 10.1016/J.CHOM.2024.07.010

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization

Author(s): H Isokääntä, L Pinto da Silva, N Karu, T Kallonen, A-K Aatsinki, T Hankemeier, L Schimmel, E Diaz, T Hyötyläinen, P C Dorrestein, R Knight, M Orešič, R Kaddurah-Daouk, A M Dickens, S Lamichhane
Published in: Analytical Chemistry, ISSN 1520-6882
Publisher: ACS publications
DOI: 10.1021/ACS.ANALCHEM.3C04436

Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis

Author(s): Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64381-3

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Author(s): Partho Sen; Matej Orešič
Published in: Metabolites, 2023, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo13070855

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants

Author(s): Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Published in: Cell Reports, Issue 44, 2025, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115731

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Author(s): Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, null null, Aafje Dotinga, Sanne Gordijn, Soesma Jankipersadsing, Ank de Jonge, Marlou L. A. de Kroon, Gerard H. Koppelman, Lilian L. Peters, Jelmer R. Prins, Sijmen A. Reijneveld, Morris A. Swertz, Henkjan J. Verkade, Jackie Dekens, Jan Sikkema, Folkert Kuipers, Andrey N. Shkoporov, Colin Hill, Sicco Scherjon, Cisca Wijmenga, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-45257-4

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Author(s): Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Published in: Nutrients, 2024, ISSN 2072-6643
Publisher: MDPI
DOI: 10.3390/NU16111708

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Author(s): Santosh Lamichhane; Taina Härkönen; Tommi Vatanen; Tuulia Hyötyläinen; Mikael Knip; Matej Orešič
Published in: Environment international, 2023, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1101/2022.12.14.22283359

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Author(s): Lamichhane Santosh , Sen Partho , Dickens Alex M. , Kråkström Matilda , Ilonen Jorma , Lempainen Johanna , Hyöty Heikki , Lahesmaa Riitta , Veijola Riitta , Toppari Jorma , Hyötyläinen Tuulia , Knip Mikael , Orešič Matej
Published in: Frontiers in endocrinology, ISSN 1664-2392
Publisher: frontiers
DOI: 10.3389/FENDO.2023.1211015

Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition

Author(s): Karla Rio-Aige, Marta Selma-Royo, Raúl Cabrera-Rubio, Sonia González, Cecilia Martínez-Costa, Margarida Castell, María J. Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Published in: eBioMedicine, Issue 118, 2025, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105850

Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort

Author(s): Mihail Mihov, Hannah Shoctor, Alex Douglas, David C. Hay, Peter J. O'Shaughnessy, John P. Iredale, Sophie Shaw, Paul A. Fowler, Felix Grassmann
Published in: eBioMedicine, Issue 114, 2025, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105590

Host and environmental determinants of human milk oligosaccharides and microbiota in the Lifelines NEXT cohort

Author(s): Johanne E. Spreckels, Alexander Kurilshikov, Asier Fernández-Pato, Fan Liu, Siobhan Brushett, Corinna Bang, Daria V. Zhernakova, Marloes Kruk, Trishla Sinha, Sanzhima Garmaeva, Milla F. Brandao Gois, Esteban A. Lopera-Maya, Laura A. Bolte, Soesma A. Jankipersadsing, Andre Franke, Hanne L.P. Tytgat, Sara Colombo Mottaz, Jingyuan Fu, Сyrus A. Mallon, Sander S. van Leeuwen, Ranko Gacesa, Alexandra Zhernakova
Published in: Cell Reports, Issue 44, 2026, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2025.116124

Longitudinal gut microbiota tracking reveals the dynamics of horizontal gene transfer

Author(s): Haoran Peng, Sergio Andreu-Sanchez, Angel J. Ruiz-Moreno, Asier Fernández-Pato, Jiafei Wu, Ranko Gacesa, Alexandra Zhernakova, Daoming Wang, Jingyuan Fu
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66612-Z

Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life

Author(s): Karla Rio-Aige, Cecilia Martínez-Costa, Margarida Castell, María José Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Published in: International Breastfeeding Journal, Issue 20, 2025, ISSN 1746-4358
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13006-025-00770-0

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study Author links

Author(s): Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
Published in: The Lancet Planetary Health, 2024, ISSN 2542-5196
Publisher: Elsevier
DOI: 10.1016/S2542-5196(23)00257-7

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Author(s): Sergio Andreu-Sánchez, Arno R. Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Angel J. Ruiz-Moreno, Shixian Hu, Trishla Sinha, Arnau Vich Vila, Shelley Klompus, Iris N. Kalka, Karina de Leeuw, Suzanne Arends, Iris Jonkers, Sebo Withoff, El
Published in: Immunity, ISSN 1074-7613
Publisher: Elsevier
DOI: 10.1016/J.IMMUNI.2023.04.003

Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

Author(s): Bruzzaniti S, Piemonte E, Bruzzese D, Lepore MT, Strollo R, Izzo L, Di Candia F, Franzese A, Bifulco M, Mozzillo E, Ludvigsson J, Matarese G, Galgani M
Published in: Diabetologia, ISSN 1432-0428
Publisher: Springer
DOI: 10.1007/S00125-023-06075-3

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Author(s): Fernández-Pato A, Sinha T, Gacesa R, Andreu-Sánchez S, Gois MFB, Gelderloos-Arends J, Jansen DBH, Kruk M, Jaeger M, Joosten LAB, Netea MG, Weersma RK, Wijmenga C, Harmsen HJM, Fu J, Zhernakova A, Kurilshikov A
Published in: Scientific Reports, ISSN 2045-2322
Publisher: Nature
DOI: 10.1038/S41598-024-54353-W

Comprehensive Targeted and Quantitative Profiling of the Human Milk Metabolome: Impact of Delivery Mode, Breastfeeding Practices, and Maternal Diet

Author(s): Joaquim Calvo‐Lerma, Raúl Cabrera‐Rubio, Carles Lerin, Sonia González, Marta Selma‐Royo, Cecilia Martínez‐Costa, Teodoro Bottiglieri, Maria Carmen Collado
Published in: Molecular Nutrition & Food Research, Issue 68, 2024, ISSN 1613-4125
Publisher: Wiley
DOI: 10.1002/MNFR.202400424

The inflammatory path toward type 1 diabetes begins during pregnancy

Author(s): Angelica P. Ahrens, Raquel Dias, Tuulia Hyötyläinen, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67712-6

Recent advances towards mass spectrometry-based clinical lipidomics

Author(s): Samira Salihovic, Santosh Lamichane, Tuulia Hyötyläinen, Matej Orešič
Published in: Current Opinion in Chemical Biology, 2023, ISSN 1367-5931
Publisher: Elsevier
DOI: 10.1016/J.CBPA.2023.102370

Advantages of anti‐endomysial evaluation in children with low titers of anti‐transglutaminase antibodies: A retrospective study

Author(s): Roberta Mandile, Chiara Esposito, Maria Pia Basile, Mariantonia Maglio, Riccardo Troncone, Renata Auricchio
Published in: Journal of Pediatric Gastroenterology and Nutrition, Issue 81, 2025, ISSN 0277-2116
Publisher: Wiley
DOI: 10.1002/JPN3.70214

Dynamics of gut metabolome and microbiota maturation during early life

Author(s): Anna-Katariina Aatsinki, Santosh Lamichhane, Heidi Isokääntä, Partho Sen, Matilda Kråkström, Marina Amaral Alves, Anniina Keskitalo, Eveliina Munukka, Hasse Karlsson, Laura Perasto, Minna Lukkarinen, Matej Oresic, Henna-Maria Kailanto, Linnea Karlsson, Leo Lahti, Alex M. Dickens
Published in: iScience, Issue 28, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2025.113596

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Author(s): Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Published in: Immunity, Issue VOLUME=56;ISSUE=6;STARTPAGE=1;ENDPAGE=17;ISSN=1074-7613, 2023, ISSN 1074-7613
Publisher: Elsevier
DOI: 10.1016/j.immuni.2023.04.017

Infant microbes and metabolites point to childhood neurodevelopmental disorders

Author(s): Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Published in: Cell, ISSN 1097-4172
Publisher: Elsevier
DOI: 10.1016/J.CELL.2024.02.035

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming

Author(s): Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado
Published in: Cell Host & Microbe, Issue 33, 2025, ISSN 1931-3128
Publisher: Elsevier BV
DOI: 10.1016/J.CHOM.2025.05.014

Immune development differs between preterm newborns fed mothers’ own milk and donor milk

Author(s): Ziyang Tan, Wen Zhong, Hanna Danielsson, Aron Arzoomand, Tadepally Lakshmikanth, Qi Chen, Jaromir Mikes, Jun Wang, Yang Chen, Anna James, Anders K. Nilsson, Anders Elfvin, Nele Brusselaers, Theo Portlock, Pia Lundgren, Karin Sävman, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Mathias Uhlén, Ann Hellström, Petter Brodin
Published in: iScience, Issue 28, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112918

Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation

Author(s): Jiafei Wu, Victoria Palasantzas, Sergio Andreu-Sánchez, Torsten Plösch, Sam Leonard, Shuang Li, Marc Jan Bonder, Harm-Jan Westra, Joyce van Meurs, Mohsen Ghanbari, Lude Franke, Alexandra Zhernakova, Jingyuan Fu, Joanne A. Hoogerland, Daria V. Zhernakova
Published in: Clinical Epigenetics, Issue 16, 2024, ISSN 1868-7083
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13148-024-01718-7

Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome

Author(s): Anna Samarra, Alejandro J. Alcañiz, Cecilia Martínez-Costa, Alberto Marina, Iñaki Comas, Nicola Segata, Narciso M. Quijada, Maria Carmen Collado
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61154-W

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Author(s): Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Published in: Allergy, 2026, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.70218

A set of serum proteomic biomarkers differentiates celiac children from age and human leukocyte antigen‐matched healthy controls

Author(s): Roberta Mandile, Michele Francesco di Tolla, Martina Carpinelli, Janneke Nicoline Samsom, Rossella De Cegli, Maria Vittoria Barone, Riccardo Troncone, Pietro Formisano, Luigi Greco, Renata Auricchio
Published in: Journal of Pediatric Gastroenterology and Nutrition, Issue 82, 2026, ISSN 0277-2116
Publisher: Wiley
DOI: 10.1002/JPN3.70261

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Author(s): Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Published in: Nutrients, Issue 16, 2025, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/NU16111708

Proteomic Biomarkers in Serum Predict Villous Atrophy Development in Asymptomatic Potential Celiac Disease Children at Time of Diagnosis

Author(s): Renata Auricchio, Roberta Mandile, Janneke Samsom, Chiara Esposito, Rossella de Cegli, Luigi Greco, Riccardo Troncone, Maria Vittoria Barone, Mariantonia Maglio
Published in: Gastroenterology, Issue 168, 2025, ISSN 0016-5085
Publisher: Elsevier BV
DOI: 10.1053/J.GASTRO.2024.09.001

Identification and characterization of <i>Faecalibacterium</i> prophages rich in diversity-generating retroelements

Author(s): Anastasia Gulyaeva, Lei Liu, Sanzhima Garmaeva, Marloes Kruk, Rinse K. Weersma, Hermie J. M. Harmsen, Alexandra Zhernakova
Published in: Microbiology Spectrum, Issue 13, 2025, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/SPECTRUM.01066-24

Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

Author(s): Maria Teresa Lepore, Sara Bruzzaniti, Claudia La Rocca, Clorinda Fusco, Fortunata Carbone, Maria Mottola, Bruno Zuccarelli, Roberta Lanzillo, Vincenzo Brescia Morra, Giorgia Teresa Maniscalco, Salvatore De Simone, Claudio Procaccini, Antonio Porcellini, Veronica De Rosa, Mario Galgani, Silvana Cassano, Giuseppe Matarese
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-68098-Z

The maternal gut microbiome in pregnancy: implications for the developing immune system

Author(s): Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar & Maria Carmen Collado
Published in: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5053
Publisher: nature
DOI: 10.1038/S41575-023-00864-2

Host genetic regulation of human gut microbial structural variation

Author(s): Daria V. Zhernakova, Daoming Wang, Lei Liu, Sergio Andreu-Sánchez, Yue Zhang, Angel J. Ruiz-Moreno, Haoran Peng, Niels Plomp, Ángela Del Castillo-Izquierdo, Ranko Gacesa, Esteban A. Lopera-Maya, Godfrey S. Temba, Vesla I. Kullaya, Sander S. van Leeuwen, L
Published in: nature, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/S41586-023-06893-W

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Author(s): Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke
Published in: Genome Biology, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/S13059-023-03151-0

A reconceptualized framework for human microbiome transmission in early life

Author(s): Seth Rakoff-Nahoum, Justine Debelius, Mireia Valles-Colomer, Hanna Theodora Noordzij, Maria Esteban-Torres, Alexandra Zhernakova, Nele Brusselaers, Veronika Kuchařová Pettersen
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61998-2

Negativeome characterization and decontamination in early-life virome studies

Author(s): Nataliia Kuzub, Alexander Kurilshikov, Alexandra Zhernakova, Sanzhima Garmaeva
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61478-7

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Author(s): Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Extracorporeal Photopheresis Enhances the Frequency and Function of Highly Suppressive FoxP3+ Treg Subsets in Heart Transplanted Individuals

Author(s): Maria Mottola, Sara Bruzzaniti, Erica Piemonte, Maria Teresa Lepore, Andrea Petraio, Renata Romano, Antonella Castiglione, Lavinia Izzo, Francesco Perna, Chiara De Falco, Federico Brighel, Luigi Formisano, Maria Teresa Gravina, Marina Marino, Marisa De Feo, Giuseppe Matarese, Mario Galgani
Published in: Transplantation, Issue 109, 2025, ISSN 0041-1337
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/TP.0000000000005201

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Author(s): Santosh Lamichhane, Taina Härkönen, Tommi Vatanen, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
Published in: Environment International, Issue 176, 2025, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.107965

Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study

Author(s): Aaron Barron, Alex M Dickens, Jetro J Tuulari, Tuulia Hyötylainen, Susanna Kortesluoma, Harri Merisaari, Elmo P Pulli, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, John D Lewis, Linnea Karlsson, Matej Orešič, Hasse Karlsson
Published in: The Lancet Planetary Health, Issue 9, 2025, ISSN 2542-5196
Publisher: Elsevier BV
DOI: 10.1016/J.LANPLH.2025.101309

Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis

Author(s): Gianmarco Abbadessa, Maria Teresa Lepore, Sara Bruzzaniti, Erica Piemont, Giuseppina Miele, Elisabetta Signoriello, Francesco Perna, Chiara De Falco, G. Lus, Giuseppe Matarese, Simona Bonavita, Mario Galgani
Published in: Neurology: neuroimmunology and neuroinflammation, ISSN 2332-7812
Publisher: American Academy of Neurology
DOI: 10.1212/NXI.0000000000200250

Global genetic diversity of human gut microbiome species is related to geographic location and host health

Author(s): Sergio Andreu-Sánchez, Aitor Blanco-Míguez, Daoming Wang, Davide Golzato, Paolo Manghi, Vitor Heidrich, Gloria Fackelmann, Daria V. Zhernakova, Alexander Kurilshikov, Mireia Valles-Colomer, Rinse K. Weersma, Alexandra Zhernakova, Jingyuan Fu, Nicola Segata
Published in: Cell, Issue 188, 2025, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2025.04.014

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity

Author(s): Santosh Lamichhane, Alex M. Dickens, Tanja Buchacher, Tianai Lou, Vincent Charron-Lamoureux, Roosa Kattelus, Pragya Karmacharya, Lucas Pinto da Silva, Matilda Kråkström, Omid Rasool, Partho Sen, Corinn Walker, Abubaker Patan, Emily C. Gentry, Simone Zuffa, Aron Arzoomand, Tadepally Lakshmikanth, Jaromir Mikeš, Aman Mebrahtu, Tommi Vatanen, Manuela Raffatellu, Karsten Zengler, Tuulia Hyötyläinen, Ramnik J. Xavier, Petter Brodin, Riitta Lahesmaa, Pieter C. Dorrestein, Mikael Knip, Matej Orešič
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66619-6

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Author(s): Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, Lifelines NEXT cohort study, Jackie Dekens, Jan Sikkema, Folkert Kuipers, And
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-45257-4

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

Author(s): Bagavathy Shanmugam Karthikeyan, Tuulia Hyötyläinen, Tannaz Ghaffarzadegan, Eric Triplett, Matej Orešič, Johnny Ludvigsson
Published in: Journal of Exposure Science & Environmental Epidemiology, ISSN 1559-064X
Publisher: Springer Nature
DOI: 10.1038/S41370-024-00680-Z

The influence of pre- and postnatal exposure to air pollution and green spaces on infant’s gut microbiota: Results from the MAMI birth cohort study

Author(s): Adrià Cruells, Raúl Cabrera-Rubio, Mariona Bustamante, Dolors Pelegrí , Marta Cirach, Pol Jimenez-Arenas, Anna Samarra, Cecilia Martínez-Costa, Maria Carmen Collado, Mireia Gascon
Published in: Environmental Research, ISSN 1096-0953
Publisher: Elsevier
DOI: 10.1016/J.ENVRES.2024.119283