Inflammation in human early life: targeting impacts on life-course health

Informations projet

INITIALISE

N° de convention de subvention: 101094099

DOI

10.3030/101094099

Date de signature de la CE 24 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2028

Financé au titre de

• Health

Coût total

€ 7 451 043,75

Contribution de l’UE

€ 7 451 043,75

Coordonné par

TURUN YLIOPISTO
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project website and corporate design completed

Project website and corporate design completed.

Documents, reports (1)

Report on data already available from INITIALISE cohorts, including analytical platforms used

Report on data already available from INITIALISE cohorts, including analytical platforms used.

Publications

Peer reviewed articles (53)

Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads

Auteurs: Manuel Bernabeu, Elena Cabello-Yeves, Eduard Flores, Anna Samarra, Joanna Kimberley Summers, Alberto Marina, M Carmen Collado
Publié dans: Current Opinion in Microbiology, ISSN 1879-0364
Éditeur: Elsevier
DOI: 10.1016/J.MIB.2023.102424

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Auteurs: Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Publié dans: Allergy, 2026, ISSN 0105-4538
Éditeur: Wiley
DOI: 10.1111/ALL.70218

FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

Auteurs: Camille Bédard, Alicia Pageau, Anna Fijarczyk, David Mendoza-Salido, Alejandro J. Alcañiz, Philippe C. Després, Romain Durand, Samuel Plante, Emilie M. M. Alexander, François D. Rouleau, David F. Jordan, Adarsh Jay, Mathieu Giguère, Mégane Bernier, Jehoshua Sharma, Laetitia Maroc, Nicholas C. Gervais, Anagha C. T. Menon, Isabelle Gagnon-Arsenault, Sibbe Bakker, Johanna Rhodes, Philippe J. Dufresne, Amrita Bharat, Adnane Sellam, Domenica G. De Luca, Aleeza Gerstein, Rebecca S. Shapiro, Narciso M. Quijada, Christian R. Landry
Publié dans: Nature Microbiology, Numéro 10, 2025, ISSN 2058-5276
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41564-025-02084-7

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Auteurs: Trishla Sinha, Jelmer R. Prins, Asier Fernández-Pato, Marloes Kruk, Thomas Dierikx, Tim de Meij, Marjon de Boer, Jan Freark de Boer, Sicco Scherjon, Alexander Kurilshikov, Alexandra Zhernakova
Publié dans: Cell Host & Microbe, Numéro 32, 2025, ISSN 1931-3128
Éditeur: Elsevier BV
DOI: 10.1016/J.CHOM.2024.07.010

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization

Auteurs: H Isokääntä, L Pinto da Silva, N Karu, T Kallonen, A-K Aatsinki, T Hankemeier, L Schimmel, E Diaz, T Hyötyläinen, P C Dorrestein, R Knight, M Orešič, R Kaddurah-Daouk, A M Dickens, S Lamichhane
Publié dans: Analytical Chemistry, ISSN 1520-6882
Éditeur: ACS publications
DOI: 10.1021/ACS.ANALCHEM.3C04436

Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis

Auteurs: Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64381-3

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Auteurs: Partho Sen; Matej Orešič
Publié dans: Metabolites, 2023, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo13070855

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants

Auteurs: Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Publié dans: Cell Reports, Numéro 44, 2025, ISSN 2211-1247
Éditeur: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115731

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Auteurs: Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, null null, Aafje Dotinga, Sanne Gordijn, Soesma Jankipersadsing, Ank de Jonge, Marlou L. A. de Kroon, Gerard H. Koppelman, Lilian L. Peters, Jelmer R. Prins, Sijmen A. Reijneveld, Morris A. Swertz, Henkjan J. Verkade, Jackie Dekens, Jan Sikkema, Folkert Kuipers, Andrey N. Shkoporov, Colin Hill, Sicco Scherjon, Cisca Wijmenga, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-45257-4

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Auteurs: Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Publié dans: Nutrients, 2024, ISSN 2072-6643
Éditeur: MDPI
DOI: 10.3390/NU16111708

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Auteurs: Santosh Lamichhane; Taina Härkönen; Tommi Vatanen; Tuulia Hyötyläinen; Mikael Knip; Matej Orešič
Publié dans: Environment international, 2023, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1101/2022.12.14.22283359

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Auteurs: Lamichhane Santosh , Sen Partho , Dickens Alex M. , Kråkström Matilda , Ilonen Jorma , Lempainen Johanna , Hyöty Heikki , Lahesmaa Riitta , Veijola Riitta , Toppari Jorma , Hyötyläinen Tuulia , Knip Mikael , Orešič Matej
Publié dans: Frontiers in endocrinology, ISSN 1664-2392
Éditeur: frontiers
DOI: 10.3389/FENDO.2023.1211015

Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition

Auteurs: Karla Rio-Aige, Marta Selma-Royo, Raúl Cabrera-Rubio, Sonia González, Cecilia Martínez-Costa, Margarida Castell, María J. Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Publié dans: eBioMedicine, Numéro 118, 2025, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105850

Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort

Auteurs: Mihail Mihov, Hannah Shoctor, Alex Douglas, David C. Hay, Peter J. O'Shaughnessy, John P. Iredale, Sophie Shaw, Paul A. Fowler, Felix Grassmann
Publié dans: eBioMedicine, Numéro 114, 2025, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105590

Host and environmental determinants of human milk oligosaccharides and microbiota in the Lifelines NEXT cohort

Auteurs: Johanne E. Spreckels, Alexander Kurilshikov, Asier Fernández-Pato, Fan Liu, Siobhan Brushett, Corinna Bang, Daria V. Zhernakova, Marloes Kruk, Trishla Sinha, Sanzhima Garmaeva, Milla F. Brandao Gois, Esteban A. Lopera-Maya, Laura A. Bolte, Soesma A. Jankipersadsing, Andre Franke, Hanne L.P. Tytgat, Sara Colombo Mottaz, Jingyuan Fu, Сyrus A. Mallon, Sander S. van Leeuwen, Ranko Gacesa, Alexandra Zhernakova
Publié dans: Cell Reports, Numéro 44, 2026, ISSN 2211-1247
Éditeur: Elsevier BV
DOI: 10.1016/J.CELREP.2025.116124

Longitudinal gut microbiota tracking reveals the dynamics of horizontal gene transfer

Auteurs: Haoran Peng, Sergio Andreu-Sanchez, Angel J. Ruiz-Moreno, Asier Fernández-Pato, Jiafei Wu, Ranko Gacesa, Alexandra Zhernakova, Daoming Wang, Jingyuan Fu
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66612-Z

Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life

Auteurs: Karla Rio-Aige, Cecilia Martínez-Costa, Margarida Castell, María José Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Publié dans: International Breastfeeding Journal, Numéro 20, 2025, ISSN 1746-4358
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13006-025-00770-0

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study Author links

Auteurs: Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
Publié dans: The Lancet Planetary Health, 2024, ISSN 2542-5196
Éditeur: Elsevier
DOI: 10.1016/S2542-5196(23)00257-7

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Auteurs: Sergio Andreu-Sánchez, Arno R. Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Angel J. Ruiz-Moreno, Shixian Hu, Trishla Sinha, Arnau Vich Vila, Shelley Klompus, Iris N. Kalka, Karina de Leeuw, Suzanne Arends, Iris Jonkers, Sebo Withoff, El
Publié dans: Immunity, ISSN 1074-7613
Éditeur: Elsevier
DOI: 10.1016/J.IMMUNI.2023.04.003

Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

Auteurs: Bruzzaniti S, Piemonte E, Bruzzese D, Lepore MT, Strollo R, Izzo L, Di Candia F, Franzese A, Bifulco M, Mozzillo E, Ludvigsson J, Matarese G, Galgani M
Publié dans: Diabetologia, ISSN 1432-0428
Éditeur: Springer
DOI: 10.1007/S00125-023-06075-3

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Auteurs: Fernández-Pato A, Sinha T, Gacesa R, Andreu-Sánchez S, Gois MFB, Gelderloos-Arends J, Jansen DBH, Kruk M, Jaeger M, Joosten LAB, Netea MG, Weersma RK, Wijmenga C, Harmsen HJM, Fu J, Zhernakova A, Kurilshikov A
Publié dans: Scientific Reports, ISSN 2045-2322
Éditeur: Nature
DOI: 10.1038/S41598-024-54353-W

Comprehensive Targeted and Quantitative Profiling of the Human Milk Metabolome: Impact of Delivery Mode, Breastfeeding Practices, and Maternal Diet

Auteurs: Joaquim Calvo‐Lerma, Raúl Cabrera‐Rubio, Carles Lerin, Sonia González, Marta Selma‐Royo, Cecilia Martínez‐Costa, Teodoro Bottiglieri, Maria Carmen Collado
Publié dans: Molecular Nutrition & Food Research, Numéro 68, 2024, ISSN 1613-4125
Éditeur: Wiley
DOI: 10.1002/MNFR.202400424

The inflammatory path toward type 1 diabetes begins during pregnancy

Auteurs: Angelica P. Ahrens, Raquel Dias, Tuulia Hyötyläinen, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
Publié dans: Nature Communications, Numéro 17, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67712-6

Recent advances towards mass spectrometry-based clinical lipidomics

Auteurs: Samira Salihovic, Santosh Lamichane, Tuulia Hyötyläinen, Matej Orešič
Publié dans: Current Opinion in Chemical Biology, 2023, ISSN 1367-5931
Éditeur: Elsevier
DOI: 10.1016/J.CBPA.2023.102370

Advantages of anti‐endomysial evaluation in children with low titers of anti‐transglutaminase antibodies: A retrospective study

Auteurs: Roberta Mandile, Chiara Esposito, Maria Pia Basile, Mariantonia Maglio, Riccardo Troncone, Renata Auricchio
Publié dans: Journal of Pediatric Gastroenterology and Nutrition, Numéro 81, 2025, ISSN 0277-2116
Éditeur: Wiley
DOI: 10.1002/JPN3.70214

Dynamics of gut metabolome and microbiota maturation during early life

Auteurs: Anna-Katariina Aatsinki, Santosh Lamichhane, Heidi Isokääntä, Partho Sen, Matilda Kråkström, Marina Amaral Alves, Anniina Keskitalo, Eveliina Munukka, Hasse Karlsson, Laura Perasto, Minna Lukkarinen, Matej Oresic, Henna-Maria Kailanto, Linnea Karlsson, Leo Lahti, Alex M. Dickens
Publié dans: iScience, Numéro 28, 2025, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/J.ISCI.2025.113596

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Auteurs: Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Publié dans: Immunity, Numéro VOLUME=56;ISSUE=6;STARTPAGE=1;ENDPAGE=17;ISSN=1074-7613, 2023, ISSN 1074-7613
Éditeur: Elsevier
DOI: 10.1016/j.immuni.2023.04.017

Infant microbes and metabolites point to childhood neurodevelopmental disorders

Auteurs: Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Publié dans: Cell, ISSN 1097-4172
Éditeur: Elsevier
DOI: 10.1016/J.CELL.2024.02.035

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming

Auteurs: Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado
Publié dans: Cell Host & Microbe, Numéro 33, 2025, ISSN 1931-3128
Éditeur: Elsevier BV
DOI: 10.1016/J.CHOM.2025.05.014

Immune development differs between preterm newborns fed mothers’ own milk and donor milk

Auteurs: Ziyang Tan, Wen Zhong, Hanna Danielsson, Aron Arzoomand, Tadepally Lakshmikanth, Qi Chen, Jaromir Mikes, Jun Wang, Yang Chen, Anna James, Anders K. Nilsson, Anders Elfvin, Nele Brusselaers, Theo Portlock, Pia Lundgren, Karin Sävman, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Mathias Uhlén, Ann Hellström, Petter Brodin
Publié dans: iScience, Numéro 28, 2025, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112918

Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation

Auteurs: Jiafei Wu, Victoria Palasantzas, Sergio Andreu-Sánchez, Torsten Plösch, Sam Leonard, Shuang Li, Marc Jan Bonder, Harm-Jan Westra, Joyce van Meurs, Mohsen Ghanbari, Lude Franke, Alexandra Zhernakova, Jingyuan Fu, Joanne A. Hoogerland, Daria V. Zhernakova
Publié dans: Clinical Epigenetics, Numéro 16, 2024, ISSN 1868-7083
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13148-024-01718-7

Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome

Auteurs: Anna Samarra, Alejandro J. Alcañiz, Cecilia Martínez-Costa, Alberto Marina, Iñaki Comas, Nicola Segata, Narciso M. Quijada, Maria Carmen Collado
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61154-W

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Auteurs: Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Publié dans: Allergy, 2026, ISSN 0105-4538
Éditeur: Wiley
DOI: 10.1111/ALL.70218

A set of serum proteomic biomarkers differentiates celiac children from age and human leukocyte antigen‐matched healthy controls

Auteurs: Roberta Mandile, Michele Francesco di Tolla, Martina Carpinelli, Janneke Nicoline Samsom, Rossella De Cegli, Maria Vittoria Barone, Riccardo Troncone, Pietro Formisano, Luigi Greco, Renata Auricchio
Publié dans: Journal of Pediatric Gastroenterology and Nutrition, Numéro 82, 2026, ISSN 0277-2116
Éditeur: Wiley
DOI: 10.1002/JPN3.70261

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Auteurs: Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Publié dans: Nutrients, Numéro 16, 2025, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/NU16111708

Proteomic Biomarkers in Serum Predict Villous Atrophy Development in Asymptomatic Potential Celiac Disease Children at Time of Diagnosis

Auteurs: Renata Auricchio, Roberta Mandile, Janneke Samsom, Chiara Esposito, Rossella de Cegli, Luigi Greco, Riccardo Troncone, Maria Vittoria Barone, Mariantonia Maglio
Publié dans: Gastroenterology, Numéro 168, 2025, ISSN 0016-5085
Éditeur: Elsevier BV
DOI: 10.1053/J.GASTRO.2024.09.001

Identification and characterization of <i>Faecalibacterium</i> prophages rich in diversity-generating retroelements

Auteurs: Anastasia Gulyaeva, Lei Liu, Sanzhima Garmaeva, Marloes Kruk, Rinse K. Weersma, Hermie J. M. Harmsen, Alexandra Zhernakova
Publié dans: Microbiology Spectrum, Numéro 13, 2025, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/SPECTRUM.01066-24

Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

Auteurs: Maria Teresa Lepore, Sara Bruzzaniti, Claudia La Rocca, Clorinda Fusco, Fortunata Carbone, Maria Mottola, Bruno Zuccarelli, Roberta Lanzillo, Vincenzo Brescia Morra, Giorgia Teresa Maniscalco, Salvatore De Simone, Claudio Procaccini, Antonio Porcellini, Veronica De Rosa, Mario Galgani, Silvana Cassano, Giuseppe Matarese
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-68098-Z

The maternal gut microbiome in pregnancy: implications for the developing immune system

Auteurs: Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar & Maria Carmen Collado
Publié dans: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5053
Éditeur: nature
DOI: 10.1038/S41575-023-00864-2

Host genetic regulation of human gut microbial structural variation

Auteurs: Daria V. Zhernakova, Daoming Wang, Lei Liu, Sergio Andreu-Sánchez, Yue Zhang, Angel J. Ruiz-Moreno, Haoran Peng, Niels Plomp, Ángela Del Castillo-Izquierdo, Ranko Gacesa, Esteban A. Lopera-Maya, Godfrey S. Temba, Vesla I. Kullaya, Sander S. van Leeuwen, L
Publié dans: nature, ISSN 1476-4687
Éditeur: Nature
DOI: 10.1038/S41586-023-06893-W

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Auteurs: Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke
Publié dans: Genome Biology, ISSN 1474-760X
Éditeur: Springer Nature
DOI: 10.1186/S13059-023-03151-0

A reconceptualized framework for human microbiome transmission in early life

Auteurs: Seth Rakoff-Nahoum, Justine Debelius, Mireia Valles-Colomer, Hanna Theodora Noordzij, Maria Esteban-Torres, Alexandra Zhernakova, Nele Brusselaers, Veronika Kuchařová Pettersen
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61998-2

Negativeome characterization and decontamination in early-life virome studies

Auteurs: Nataliia Kuzub, Alexander Kurilshikov, Alexandra Zhernakova, Sanzhima Garmaeva
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61478-7

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Auteurs: Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Extracorporeal Photopheresis Enhances the Frequency and Function of Highly Suppressive FoxP3+ Treg Subsets in Heart Transplanted Individuals

Auteurs: Maria Mottola, Sara Bruzzaniti, Erica Piemonte, Maria Teresa Lepore, Andrea Petraio, Renata Romano, Antonella Castiglione, Lavinia Izzo, Francesco Perna, Chiara De Falco, Federico Brighel, Luigi Formisano, Maria Teresa Gravina, Marina Marino, Marisa De Feo, Giuseppe Matarese, Mario Galgani
Publié dans: Transplantation, Numéro 109, 2025, ISSN 0041-1337
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/TP.0000000000005201

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Auteurs: Santosh Lamichhane, Taina Härkönen, Tommi Vatanen, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
Publié dans: Environment International, Numéro 176, 2025, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.107965

Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study

Auteurs: Aaron Barron, Alex M Dickens, Jetro J Tuulari, Tuulia Hyötylainen, Susanna Kortesluoma, Harri Merisaari, Elmo P Pulli, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, John D Lewis, Linnea Karlsson, Matej Orešič, Hasse Karlsson
Publié dans: The Lancet Planetary Health, Numéro 9, 2025, ISSN 2542-5196
Éditeur: Elsevier BV
DOI: 10.1016/J.LANPLH.2025.101309

Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis

Auteurs: Gianmarco Abbadessa, Maria Teresa Lepore, Sara Bruzzaniti, Erica Piemont, Giuseppina Miele, Elisabetta Signoriello, Francesco Perna, Chiara De Falco, G. Lus, Giuseppe Matarese, Simona Bonavita, Mario Galgani
Publié dans: Neurology: neuroimmunology and neuroinflammation, ISSN 2332-7812
Éditeur: American Academy of Neurology
DOI: 10.1212/NXI.0000000000200250

Global genetic diversity of human gut microbiome species is related to geographic location and host health

Auteurs: Sergio Andreu-Sánchez, Aitor Blanco-Míguez, Daoming Wang, Davide Golzato, Paolo Manghi, Vitor Heidrich, Gloria Fackelmann, Daria V. Zhernakova, Alexander Kurilshikov, Mireia Valles-Colomer, Rinse K. Weersma, Alexandra Zhernakova, Jingyuan Fu, Nicola Segata
Publié dans: Cell, Numéro 188, 2025, ISSN 0092-8674
Éditeur: Elsevier BV
DOI: 10.1016/J.CELL.2025.04.014

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity

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