Inflammation in human early life: targeting impacts on life-course health

Informazioni relative al progetto

INITIALISE

ID dell’accordo di sovvenzione: 101094099

DOI

10.3030/101094099

Data della firma CE 24 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2028

Finanziato da

• Health

Costo totale

€ 7 451 043,75

Contributo UE

€ 7 451 043,75

Coordinato da

TURUN YLIOPISTO
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Project website and corporate design completed

Project website and corporate design completed.

Documents, reports (1)

Report on data already available from INITIALISE cohorts, including analytical platforms used

Report on data already available from INITIALISE cohorts, including analytical platforms used.

Pubblicazioni

Peer reviewed articles (53)

Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads

Autori: Manuel Bernabeu, Elena Cabello-Yeves, Eduard Flores, Anna Samarra, Joanna Kimberley Summers, Alberto Marina, M Carmen Collado
Pubblicato in: Current Opinion in Microbiology, ISSN 1879-0364
Editore: Elsevier
DOI: 10.1016/J.MIB.2023.102424

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Autori: Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Pubblicato in: Allergy, 2026, ISSN 0105-4538
Editore: Wiley
DOI: 10.1111/ALL.70218

FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

Autori: Camille Bédard, Alicia Pageau, Anna Fijarczyk, David Mendoza-Salido, Alejandro J. Alcañiz, Philippe C. Després, Romain Durand, Samuel Plante, Emilie M. M. Alexander, François D. Rouleau, David F. Jordan, Adarsh Jay, Mathieu Giguère, Mégane Bernier, Jehoshua Sharma, Laetitia Maroc, Nicholas C. Gervais, Anagha C. T. Menon, Isabelle Gagnon-Arsenault, Sibbe Bakker, Johanna Rhodes, Philippe J. Dufresne, Amrita Bharat, Adnane Sellam, Domenica G. De Luca, Aleeza Gerstein, Rebecca S. Shapiro, Narciso M. Quijada, Christian R. Landry
Pubblicato in: Nature Microbiology, Numero 10, 2025, ISSN 2058-5276
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41564-025-02084-7

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Autori: Trishla Sinha, Jelmer R. Prins, Asier Fernández-Pato, Marloes Kruk, Thomas Dierikx, Tim de Meij, Marjon de Boer, Jan Freark de Boer, Sicco Scherjon, Alexander Kurilshikov, Alexandra Zhernakova
Pubblicato in: Cell Host & Microbe, Numero 32, 2025, ISSN 1931-3128
Editore: Elsevier BV
DOI: 10.1016/J.CHOM.2024.07.010

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization

Autori: H Isokääntä, L Pinto da Silva, N Karu, T Kallonen, A-K Aatsinki, T Hankemeier, L Schimmel, E Diaz, T Hyötyläinen, P C Dorrestein, R Knight, M Orešič, R Kaddurah-Daouk, A M Dickens, S Lamichhane
Pubblicato in: Analytical Chemistry, ISSN 1520-6882
Editore: ACS publications
DOI: 10.1021/ACS.ANALCHEM.3C04436

Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis

Autori: Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64381-3

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Autori: Partho Sen; Matej Orešič
Pubblicato in: Metabolites, 2023, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo13070855

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants

Autori: Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Pubblicato in: Cell Reports, Numero 44, 2025, ISSN 2211-1247
Editore: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115731

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Autori: Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, null null, Aafje Dotinga, Sanne Gordijn, Soesma Jankipersadsing, Ank de Jonge, Marlou L. A. de Kroon, Gerard H. Koppelman, Lilian L. Peters, Jelmer R. Prins, Sijmen A. Reijneveld, Morris A. Swertz, Henkjan J. Verkade, Jackie Dekens, Jan Sikkema, Folkert Kuipers, Andrey N. Shkoporov, Colin Hill, Sicco Scherjon, Cisca Wijmenga, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-45257-4

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Autori: Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Pubblicato in: Nutrients, 2024, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/NU16111708

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Autori: Santosh Lamichhane; Taina Härkönen; Tommi Vatanen; Tuulia Hyötyläinen; Mikael Knip; Matej Orešič
Pubblicato in: Environment international, 2023, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1101/2022.12.14.22283359

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Autori: Lamichhane Santosh , Sen Partho , Dickens Alex M. , Kråkström Matilda , Ilonen Jorma , Lempainen Johanna , Hyöty Heikki , Lahesmaa Riitta , Veijola Riitta , Toppari Jorma , Hyötyläinen Tuulia , Knip Mikael , Orešič Matej
Pubblicato in: Frontiers in endocrinology, ISSN 1664-2392
Editore: frontiers
DOI: 10.3389/FENDO.2023.1211015

Maternal diet shapes infant microbiota and defensive capacity against infections in early life via differential human milk composition

Autori: Karla Rio-Aige, Marta Selma-Royo, Raúl Cabrera-Rubio, Sonia González, Cecilia Martínez-Costa, Margarida Castell, María J. Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Pubblicato in: eBioMedicine, Numero 118, 2025, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105850

Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort

Autori: Mihail Mihov, Hannah Shoctor, Alex Douglas, David C. Hay, Peter J. O'Shaughnessy, John P. Iredale, Sophie Shaw, Paul A. Fowler, Felix Grassmann
Pubblicato in: eBioMedicine, Numero 114, 2025, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105590

Host and environmental determinants of human milk oligosaccharides and microbiota in the Lifelines NEXT cohort

Autori: Johanne E. Spreckels, Alexander Kurilshikov, Asier Fernández-Pato, Fan Liu, Siobhan Brushett, Corinna Bang, Daria V. Zhernakova, Marloes Kruk, Trishla Sinha, Sanzhima Garmaeva, Milla F. Brandao Gois, Esteban A. Lopera-Maya, Laura A. Bolte, Soesma A. Jankipersadsing, Andre Franke, Hanne L.P. Tytgat, Sara Colombo Mottaz, Jingyuan Fu, Сyrus A. Mallon, Sander S. van Leeuwen, Ranko Gacesa, Alexandra Zhernakova
Pubblicato in: Cell Reports, Numero 44, 2026, ISSN 2211-1247
Editore: Elsevier BV
DOI: 10.1016/J.CELREP.2025.116124

Longitudinal gut microbiota tracking reveals the dynamics of horizontal gene transfer

Autori: Haoran Peng, Sergio Andreu-Sanchez, Angel J. Ruiz-Moreno, Asier Fernández-Pato, Jiafei Wu, Ranko Gacesa, Alexandra Zhernakova, Daoming Wang, Jingyuan Fu
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66612-Z

Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life

Autori: Karla Rio-Aige, Cecilia Martínez-Costa, Margarida Castell, María José Rodríguez-Lagunas, María Carmen Collado, Francisco J. Pérez-Cano
Pubblicato in: International Breastfeeding Journal, Numero 20, 2025, ISSN 1746-4358
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13006-025-00770-0

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study Author links

Autori: Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
Pubblicato in: The Lancet Planetary Health, 2024, ISSN 2542-5196
Editore: Elsevier
DOI: 10.1016/S2542-5196(23)00257-7

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Autori: Sergio Andreu-Sánchez, Arno R. Bourgonje, Thomas Vogl, Alexander Kurilshikov, Sigal Leviatan, Angel J. Ruiz-Moreno, Shixian Hu, Trishla Sinha, Arnau Vich Vila, Shelley Klompus, Iris N. Kalka, Karina de Leeuw, Suzanne Arends, Iris Jonkers, Sebo Withoff, El
Pubblicato in: Immunity, ISSN 1074-7613
Editore: Elsevier
DOI: 10.1016/J.IMMUNI.2023.04.003

Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

Autori: Bruzzaniti S, Piemonte E, Bruzzese D, Lepore MT, Strollo R, Izzo L, Di Candia F, Franzese A, Bifulco M, Mozzillo E, Ludvigsson J, Matarese G, Galgani M
Pubblicato in: Diabetologia, ISSN 1432-0428
Editore: Springer
DOI: 10.1007/S00125-023-06075-3

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Autori: Fernández-Pato A, Sinha T, Gacesa R, Andreu-Sánchez S, Gois MFB, Gelderloos-Arends J, Jansen DBH, Kruk M, Jaeger M, Joosten LAB, Netea MG, Weersma RK, Wijmenga C, Harmsen HJM, Fu J, Zhernakova A, Kurilshikov A
Pubblicato in: Scientific Reports, ISSN 2045-2322
Editore: Nature
DOI: 10.1038/S41598-024-54353-W

Comprehensive Targeted and Quantitative Profiling of the Human Milk Metabolome: Impact of Delivery Mode, Breastfeeding Practices, and Maternal Diet

Autori: Joaquim Calvo‐Lerma, Raúl Cabrera‐Rubio, Carles Lerin, Sonia González, Marta Selma‐Royo, Cecilia Martínez‐Costa, Teodoro Bottiglieri, Maria Carmen Collado
Pubblicato in: Molecular Nutrition & Food Research, Numero 68, 2024, ISSN 1613-4125
Editore: Wiley
DOI: 10.1002/MNFR.202400424

The inflammatory path toward type 1 diabetes begins during pregnancy

Autori: Angelica P. Ahrens, Raquel Dias, Tuulia Hyötyläinen, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67712-6

Recent advances towards mass spectrometry-based clinical lipidomics

Autori: Samira Salihovic, Santosh Lamichane, Tuulia Hyötyläinen, Matej Orešič
Pubblicato in: Current Opinion in Chemical Biology, 2023, ISSN 1367-5931
Editore: Elsevier
DOI: 10.1016/J.CBPA.2023.102370

Advantages of anti‐endomysial evaluation in children with low titers of anti‐transglutaminase antibodies: A retrospective study

Autori: Roberta Mandile, Chiara Esposito, Maria Pia Basile, Mariantonia Maglio, Riccardo Troncone, Renata Auricchio
Pubblicato in: Journal of Pediatric Gastroenterology and Nutrition, Numero 81, 2025, ISSN 0277-2116
Editore: Wiley
DOI: 10.1002/JPN3.70214

Dynamics of gut metabolome and microbiota maturation during early life

Autori: Anna-Katariina Aatsinki, Santosh Lamichhane, Heidi Isokääntä, Partho Sen, Matilda Kråkström, Marina Amaral Alves, Anniina Keskitalo, Eveliina Munukka, Hasse Karlsson, Laura Perasto, Minna Lukkarinen, Matej Oresic, Henna-Maria Kailanto, Linnea Karlsson, Leo Lahti, Alex M. Dickens
Pubblicato in: iScience, Numero 28, 2025, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2025.113596

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Autori: Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Pubblicato in: Immunity, Numero VOLUME=56;ISSUE=6;STARTPAGE=1;ENDPAGE=17;ISSN=1074-7613, 2023, ISSN 1074-7613
Editore: Elsevier
DOI: 10.1016/j.immuni.2023.04.017

Infant microbes and metabolites point to childhood neurodevelopmental disorders

Autori: Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Pubblicato in: Cell, ISSN 1097-4172
Editore: Elsevier
DOI: 10.1016/J.CELL.2024.02.035

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming

Autori: Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado
Pubblicato in: Cell Host & Microbe, Numero 33, 2025, ISSN 1931-3128
Editore: Elsevier BV
DOI: 10.1016/J.CHOM.2025.05.014

Immune development differs between preterm newborns fed mothers’ own milk and donor milk

Autori: Ziyang Tan, Wen Zhong, Hanna Danielsson, Aron Arzoomand, Tadepally Lakshmikanth, Qi Chen, Jaromir Mikes, Jun Wang, Yang Chen, Anna James, Anders K. Nilsson, Anders Elfvin, Nele Brusselaers, Theo Portlock, Pia Lundgren, Karin Sävman, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Mathias Uhlén, Ann Hellström, Petter Brodin
Pubblicato in: iScience, Numero 28, 2025, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112918

Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation

Autori: Jiafei Wu, Victoria Palasantzas, Sergio Andreu-Sánchez, Torsten Plösch, Sam Leonard, Shuang Li, Marc Jan Bonder, Harm-Jan Westra, Joyce van Meurs, Mohsen Ghanbari, Lude Franke, Alexandra Zhernakova, Jingyuan Fu, Joanne A. Hoogerland, Daria V. Zhernakova
Pubblicato in: Clinical Epigenetics, Numero 16, 2024, ISSN 1868-7083
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13148-024-01718-7

Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome

Autori: Anna Samarra, Alejandro J. Alcañiz, Cecilia Martínez-Costa, Alberto Marina, Iñaki Comas, Nicola Segata, Narciso M. Quijada, Maria Carmen Collado
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61154-W

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development

Autori: Courtney M. Jackson, Maria Carmen Collado, David C. Dallas, Richard A. Insel, Andrew J. Macpherson, Debra J. Palmer, Antti E. Seppo, Valerie Verhasselt, Kirsi M. Järvinen
Pubblicato in: Allergy, 2026, ISSN 0105-4538
Editore: Wiley
DOI: 10.1111/ALL.70218

A set of serum proteomic biomarkers differentiates celiac children from age and human leukocyte antigen‐matched healthy controls

Autori: Roberta Mandile, Michele Francesco di Tolla, Martina Carpinelli, Janneke Nicoline Samsom, Rossella De Cegli, Maria Vittoria Barone, Riccardo Troncone, Pietro Formisano, Luigi Greco, Renata Auricchio
Pubblicato in: Journal of Pediatric Gastroenterology and Nutrition, Numero 82, 2026, ISSN 0277-2116
Editore: Wiley
DOI: 10.1002/JPN3.70261

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet

Autori: Roberta Mandile, Federica Lerro, Martina Carpinelli, Lorenzo D’Antonio, Luigi Greco, Riccardo Troncone, Renata Auricchio
Pubblicato in: Nutrients, Numero 16, 2025, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/NU16111708

Proteomic Biomarkers in Serum Predict Villous Atrophy Development in Asymptomatic Potential Celiac Disease Children at Time of Diagnosis

Autori: Renata Auricchio, Roberta Mandile, Janneke Samsom, Chiara Esposito, Rossella de Cegli, Luigi Greco, Riccardo Troncone, Maria Vittoria Barone, Mariantonia Maglio
Pubblicato in: Gastroenterology, Numero 168, 2025, ISSN 0016-5085
Editore: Elsevier BV
DOI: 10.1053/J.GASTRO.2024.09.001

Identification and characterization of <i>Faecalibacterium</i> prophages rich in diversity-generating retroelements

Autori: Anastasia Gulyaeva, Lei Liu, Sanzhima Garmaeva, Marloes Kruk, Rinse K. Weersma, Hermie J. M. Harmsen, Alexandra Zhernakova
Pubblicato in: Microbiology Spectrum, Numero 13, 2025, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/SPECTRUM.01066-24

Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

Autori: Maria Teresa Lepore, Sara Bruzzaniti, Claudia La Rocca, Clorinda Fusco, Fortunata Carbone, Maria Mottola, Bruno Zuccarelli, Roberta Lanzillo, Vincenzo Brescia Morra, Giorgia Teresa Maniscalco, Salvatore De Simone, Claudio Procaccini, Antonio Porcellini, Veronica De Rosa, Mario Galgani, Silvana Cassano, Giuseppe Matarese
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-68098-Z

The maternal gut microbiome in pregnancy: implications for the developing immune system

Autori: Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar & Maria Carmen Collado
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5053
Editore: nature
DOI: 10.1038/S41575-023-00864-2

Host genetic regulation of human gut microbial structural variation

Autori: Daria V. Zhernakova, Daoming Wang, Lei Liu, Sergio Andreu-Sánchez, Yue Zhang, Angel J. Ruiz-Moreno, Haoran Peng, Niels Plomp, Ángela Del Castillo-Izquierdo, Ranko Gacesa, Esteban A. Lopera-Maya, Godfrey S. Temba, Vesla I. Kullaya, Sander S. van Leeuwen, L
Pubblicato in: nature, ISSN 1476-4687
Editore: Nature
DOI: 10.1038/S41586-023-06893-W

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Autori: Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke
Pubblicato in: Genome Biology, ISSN 1474-760X
Editore: Springer Nature
DOI: 10.1186/S13059-023-03151-0

A reconceptualized framework for human microbiome transmission in early life

Autori: Seth Rakoff-Nahoum, Justine Debelius, Mireia Valles-Colomer, Hanna Theodora Noordzij, Maria Esteban-Torres, Alexandra Zhernakova, Nele Brusselaers, Veronika Kuchařová Pettersen
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61998-2

Negativeome characterization and decontamination in early-life virome studies

Autori: Nataliia Kuzub, Alexander Kurilshikov, Alexandra Zhernakova, Sanzhima Garmaeva
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61478-7

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Autori: Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Extracorporeal Photopheresis Enhances the Frequency and Function of Highly Suppressive FoxP3+ Treg Subsets in Heart Transplanted Individuals

Autori: Maria Mottola, Sara Bruzzaniti, Erica Piemonte, Maria Teresa Lepore, Andrea Petraio, Renata Romano, Antonella Castiglione, Lavinia Izzo, Francesco Perna, Chiara De Falco, Federico Brighel, Luigi Formisano, Maria Teresa Gravina, Marina Marino, Marisa De Feo, Giuseppe Matarese, Mario Galgani
Pubblicato in: Transplantation, Numero 109, 2025, ISSN 0041-1337
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/TP.0000000000005201

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Autori: Santosh Lamichhane, Taina Härkönen, Tommi Vatanen, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
Pubblicato in: Environment International, Numero 176, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.107965

Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study

Autori: Aaron Barron, Alex M Dickens, Jetro J Tuulari, Tuulia Hyötylainen, Susanna Kortesluoma, Harri Merisaari, Elmo P Pulli, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, John D Lewis, Linnea Karlsson, Matej Orešič, Hasse Karlsson
Pubblicato in: The Lancet Planetary Health, Numero 9, 2025, ISSN 2542-5196
Editore: Elsevier BV
DOI: 10.1016/J.LANPLH.2025.101309

Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis

Autori: Gianmarco Abbadessa, Maria Teresa Lepore, Sara Bruzzaniti, Erica Piemont, Giuseppina Miele, Elisabetta Signoriello, Francesco Perna, Chiara De Falco, G. Lus, Giuseppe Matarese, Simona Bonavita, Mario Galgani
Pubblicato in: Neurology: neuroimmunology and neuroinflammation, ISSN 2332-7812
Editore: American Academy of Neurology
DOI: 10.1212/NXI.0000000000200250

Global genetic diversity of human gut microbiome species is related to geographic location and host health

Autori: Sergio Andreu-Sánchez, Aitor Blanco-Míguez, Daoming Wang, Davide Golzato, Paolo Manghi, Vitor Heidrich, Gloria Fackelmann, Daria V. Zhernakova, Alexander Kurilshikov, Mireia Valles-Colomer, Rinse K. Weersma, Alexandra Zhernakova, Jingyuan Fu, Nicola Segata
Pubblicato in: Cell, Numero 188, 2025, ISSN 0092-8674
Editore: Elsevier BV
DOI: 10.1016/J.CELL.2025.04.014

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity

Autori: Santosh Lamichhane, Alex M. Dickens, Tanja Buchacher, Tianai Lou, Vincent Charron-Lamoureux, Roosa Kattelus, Pragya Karmacharya, Lucas Pinto da Silva, Matilda Kråkström, Omid Rasool, Partho Sen, Corinn Walker, Abubaker Patan, Emily C. Gentry, Simone Zuffa, Aron Arzoomand, Tadepally Lakshmikanth, Jaromir Mikeš, Aman Mebrahtu, Tommi Vatanen, Manuela Raffatellu, Karsten Zengler, Tuulia Hyötyläinen, Ramnik J. Xavier, Petter Brodin, Riitta Lahesmaa, Pieter C. Dorrestein, Mikael Knip, Matej Orešič
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66619-6

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Autori: Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, Lifelines NEXT cohort study, Jackie Dekens, Jan Sikkema, Folkert Kuipers, And
Pubblicato in: Nature Communications, 2024, ISSN 2041-1723
Editore: Springer Nature
DOI: 10.1038/S41467-024-45257-4

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

Autori: Bagavathy Shanmugam Karthikeyan, Tuulia Hyötyläinen, Tannaz Ghaffarzadegan, Eric Triplett, Matej Orešič, Johnny Ludvigsson
Pubblicato in: Journal of Exposure Science & Environmental Epidemiology, ISSN 1559-064X
Editore: Springer Nature
DOI: 10.1038/S41370-024-00680-Z

The influence of pre- and postnatal exposure to air pollution and green spaces on infant’s gut microbiota: Results from the MAMI birth cohort study

Autori: Adrià Cruells, Raúl Cabrera-Rubio, Mariona Bustamante, Dolors Pelegrí , Marta Cirach, Pol Jimenez-Arenas, Anna Samarra, Cecilia Martínez-Costa, Maria Carmen Collado, Mireia Gascon
Pubblicato in: Environmental Research, ISSN 1096-0953
Editore: Elsevier
DOI: 10.1016/J.ENVRES.2024.119283