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Systemic Endotoxemia as the driver of chronic inflammation - Biomarkers and novel therapeutic targets for Arthritis

Objective

Rheumatic diseases (RDs) affect more than 40% of Europe's population and cause significant disability, pain, reduced lifespan and a very high economic burden. In this project, we will explore the role of chronic systemic inflammation caused by intestinal microbiota derived immunologically active compounds, as a driver in the transition from health to disease, with a special focus on three RDs; osteoarthritis (OA), rheumatoid arthritis (RA), and spondylarthritis (SpA). We aim to explore the relationship between gut microbiota, intestinal permeability, and endotoxemia. We aim to understand their role as drivers of disease onset and disease activity in RA, SpA and OA, as well as targets of preventive and therapeutic approaches. We will study the events leading from health to disease onset by i) taking advantage of geographically diverse large cohorts of people with available blood and faeces samples, ii) search for novel risk biomarkers for RA, SpA, and OA by using high-throughput OMICS-based analyses iii) conducting targeted clinical studies, iv) performing in vitro mechanistic studies to explore the gut-joint axis using tissue explant cultures and organ-on-chip models v) conducting interventional proof of concept studies of diet, faecal transplantation and a gut permeability decreasing drug in RA and SpA patients, vi) exploring in vitro new potential drugs or nutraceuticals to cope with endotoxemia effects on target tissues. By combining all these results, machine learning and AI-informed rheumatic disease prediction tool will be developed for clinicians to help them identify patients with increased risk of developing the target diseases. It will thus assist in the choice of personalized blueprint intervention to reduce the risk of these diseases and disease activity in RA and SpA and to slow down the progression of OA.

Coordinator

HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Net EU contribution
€ 1 762 493,75
Address
Stenbackinkatu 9
00029 Helsinki
Finland

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Other funding
€ 0,00

Participants (11)

TARTU ULIKOOL
Estonia
Net EU contribution
€ 598 000,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
Net EU contribution
€ 581 875,00
Address
Viale Abramo Lincoln 5
81100 Caserta

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Region
Sud Campania Caserta
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
Net EU contribution
€ 490 038,75
Address
Avenida Prof Egas Moniz
1649 028 Lisboa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Other funding
€ 0,00
SERVIZO GALEGO DE SAUDE
Spain
Net EU contribution
€ 105 712,50
Address
Edificio Administrativo San Lázaro
15703 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 657 016,25
Address
Travesa Da Choupana
15706 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Research Organisations
Other funding
€ 0,00
HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 500 000,00
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TECHNISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 546 250,00
Address
Karlsplatz 13
1040 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
NEC LABORATORIES EUROPE GMBH
Germany
Net EU contribution
€ 471 742,50
Address
Kurfursten-anlage 36
69115 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

NEC ITALIA SPA
Italy
Net EU contribution
€ 124 066,25
Address
Via Cornaggia, 58
20092 Cinisello Balsamo (Mi)

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STEINBEIS 2I GMBH
Germany
Net EU contribution
€ 461 875,00
Address
Leuschnerstrasse 43
70176 Stuttgart

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FONDAZIONE EBRIS
Italy
Net EU contribution
€ 698 750,00
Address
Via De Renzi 1
84125 Salerno

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Region
Sud Campania Salerno
Activity type
Research Organisations
Other funding
€ 0,00

Partners (2)

SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
Net EU contribution
€ 0,00
Address
Rue Michel Servet 1 Cmu
1206 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Research Organisations
Other funding
€ 0,00
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00