3D spheroids derived from single cells for discovering stochastic patterns behind metastasis

Información del proyecto

3DSecret

Identificador del acuerdo de subvención: 101099066

DOI

10.3030/101099066

Fecha de la firma de la CE 16 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 2 591 050,25

Aportación de la UE

€ 2 591 050,25

Coordinado por

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Protocol for identification of genomic variants and quantification of gene expression levels in spheroids

This deliverable will provide a formal protocol detailing the recovery of spheroids for DNA and RNA extraction,  massive DNA and RNA sencing procedures, and the bioinformatic pipeline established for the reliable identification of genomic variants and gene expression levels in the spheroids.

Report of the selection of SERS substrates and strategy chosen for online metabolomics analysis.

A report compiling the results related to SERS performance for metabolomic sensing in droplets, selection of nanostructure composition, size and shape; preliminary results of integration in the microdroplets platform and identification of next steps for continuous monitoring without compromising SERS performance, cells viability and droplet stability.

Report for efficiency of traceable spheroid recovery from microfluidic devices.

A report compiling the results and selected final SOP for recovering spheroids from the growth platform, attained efficiencies and strategy for traceability for enabling subsequent genomic and transcriptomic analysis.

Plan for Dissemination and Exploitation Including Communication Activities

This plan provides a strategy and action plan concerning the communication and dissemination activities, channels, and target audience, project branding and KPIs/milestones. The deliverable also compiles the activities performed to grow the ecosystem and key stakeholders’ participation.

Website and logo

Project website and project logo information with also social media links.

Data Management Plan (2)

Data Management Plan

The DMP will provide an analysis of the main elements of the data management policy that will be used by the applications concerning all the datasets that will be generated by the project. The DMP is not a fixed document but evolves (if necessary) during the lifespan of the project, according to the Guidelines on Data Management.

Data Management Plan v2

Update of the DMP D1.2

Publicaciones

Peer reviewed articles (5)

Will data analytics revolution finally bring SERS to the clinic?

Autores: A Mahmoud, A Teixeira, M Aranda, M Relvas, S Quintero, M Sousa-Silva, A Chícharo, M Chen, M Hashemi, J King, J Tunnell, C Morasso, F Piccotti, F Corsi, M Henriksen-Lacey, D de Aberasturi, D Méndez-Merino, A Rodríguez-Patón, Sara Abalde-Cela, L Dieguez
Publicado en: TrAC Trends in Analytical Chemistry, Edición Volume 169, 117311, 2023, ISSN 0165-9936
Editor: Elsevier BV
DOI: 10.1016/j.trac.2023.117311

Intraline genomic heterogeneity of the triple-negative breast cancer MDA-MB-231-luc-GFP cell line

Autores: Nair Varela-Rouco, Nuria Estévez-Gómez, Cristóbal Fernández-Santiago, Laura Tomás, Miriam Pérez, Daniel García-Souto, Juan Jose Pasantes, Roberto Piñeiro, Joao M Alves, David Posada
Publicado en: Computational and Structural Biotechnology Journal, Edición 27, 2025, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1016/J.CSBJ.2025.06.033

Precision‐Engineered Plasmonic Nanostar Arrays for High‐Performance SERS Sensing

Autores: Alexandre Chícharo, Alexandra Teixeira, Diogo Moreira, Maria S. Relvas, Marta Aranda, Temple Douglas, Jerôme Borme, Jana B. Nieder, Lorena Diéguez, Sara Abalde‐Cela
Publicado en: Advanced Optical Materials, 2025, ISSN 2195-1071
Editor: Wiley
DOI: 10.1002/ADOM.202501275

Plasmonic nanoparticle sensors: current progress, challenges, and future prospects

Autores: Krishna Kant; Reshma Beeram; Yi Cao; Paulo S. S. dos Santos; Lara González-Cabaleiro; Daniel García-Lojo; Heng Guo; Younju Joung; Siddhant Kothadiya; Marta Lafuente; Yong Xiang Leong; Yiyi Liu; Yuxiong Liu; Sree Satya Bharati Moram; Sanje Mahasivam; Sonia Maniappan; Daniel Quesada-González; Divakar Raj; Pabudi Weerathunge; Xinyue Xia; Qian Yu; Sara Abalde-Cela; Ramon A. Alvarez-Puebla; Rizia Bardhan; Vipul Bansal; Jaebum Choo; Luis C. C. Coelho; José M. M. M. de Almeida; Sergio Gómez-Graña; Marek Grzelczak; Pablo Herves; Jatish Kumar; Theobald Lohmueller; Arben Merkoçi; José Luis Montaño-Priede; Xing Yi Ling; Reyes Mallada; Jorge Pérez-Juste; María P. Pina; Srikanth Singamaneni; Venugopal Rao Soma; Mengtao Sun; Limei Tian; Jianfang Wang; Lakshminarayana Polavarapu; Isabel Pastoriza Santos
Publicado en: Nanoscale Horizons, 2024, ISSN 2055-6764
Editor: RSC Publishing
DOI: 10.1039/D4NH00226A

Advanced Microfluidics for Single Cell‐Based Cancer Research

Autores: Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier
Publicado en: Advanced Science, 2025, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/ADVS.202500975