FUnctional Nucleic Acids as Versatile SMart BUilding BLocks in Non-ConventIonal SolvenTs

Información del proyecto

FUNAMBULIST

Identificador del acuerdo de subvención: 101099652

DOI

10.3030/101099652

Proyecto cerrado

Fecha de la firma de la CE 8 Marzo 2023

Fecha de inicio 1 Mayo 2023

Fecha de finalización 30 Abril 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 2 533 255,25

Aportación de la UE

€ 2 533 255,00

Coordinado por

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain

Periodic Reporting for period 1 - FUNAMBULIST (FUnctional Nucleic Acids as Versatile SMart BUilding BLocks in Non-ConventIonal SolvenTs)

Período documentado: 2023-05-01 hasta 2024-04-30

Resumen del contexto y de los objetivos generales del proyecto

The main objective of FUNAMBULIST is to create a modular transversal toolkit allowed to control estereoselectivity for fine chemicals synthesis by leveraging the helical chirality of nucleic acids. This is achieved by replacing water with (chiral) ionic liquids or deep eutectic solvents as the bulk solvent. Despite initial hiring challenges, the project is now on track with strong collaboration and coordination among partners.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Objective 1: Achieve semi-preparative scale synthesis of unnatural XNA oligomers.
Successfully introduced biotin and primary amine modifications, key factor to facilitate the further immobilization -and its evaluation- on membranes.

Objective 2: Synthesize sequence-defined polymers and assessed their interaction with model ionic liquids. Initial studies of interactions between sequence-controlled polymers and ionic liquids, finding that their fundamental physico-chemical properties remain unaltered.

Objective 3: Develop a screening method for nucleic acid scaffolds and evaluated bi-molecular systems in ionic liquids. Implemented new microfluidic device designs and hydrogel beads for handling modified DNAs and XNAs.

Objective 4: Synthesized new compounds capable of enhance the catalysis monitoring in the Diels-Alder reaction. Initial studies regarding membrane modification by DNA-scaffolds

Objective 5: Created a Data Management Plan and developed the FUNAMBULIST website as a communication tool. Consortium meetings were carried out and future meetings are planned.

Objective 6: Designed a Quality Management Plan and established efficient document sharing through One-Drive folder created for FUNAMBULIST.
Held regular consortium meetings to monitor progress.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Development of a novel screening method for nucleic acid scaffolds with chemical base modifications, capable of catalyzing reactions.
Innovative microfluidic device designs compatible with the properties of ionic liquids.
Develop of a several sequence-defined polymers that can serve as platform for the membrane.
New fluorescent -and more reactive- compounds were created to control de monitoring of the catalysis.
Initial studies regarding DNA-immobilization over a membrane were carried out.

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