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Next generation Limited-Angle time-of-flight PET imager

Project description

Affordable PET technology to improve cancer diagnosis

In 2020, cancer claimed the lives of 1.3 million people in the EU, with diagnoses surpassing 2.7 million. With cases projected to rise by 24 % by 2035, cancer remains the EU’s leading cause of death. Currently, Positron Emission Tomography (PET) is the most sensitive diagnostic tool available, but is limited by its high cost, restricting access to fewer than 0.5 % of medical centres worldwide. Funded by the EIC, the PetVision project aims to revolutionise this scenario by developing a modular, cost-effective PET device using advanced Time-of-Flight technology. This innovative approach promises to enhance diagnostic accuracy and accessibility across various medical environments, from standard PET centres to emergency units.

Objective

Over 2.7 million people in the EU were diagnosed with cancer in 2020, while 1.3 million people lost their lives to it. Cancer cases are
predicted to increase by 24% by 2035, making it the leading cause of death in the EU. The current leading specific molecular imaging
diagnostic technique sensitive to cancer is based on Positron Emission Tomography (PET). Due to the high implementation cost of
PET, this high-sensitivity diagnostics, is only available to less than 0,5 % of the medical centers in the world. The critical component of
the overall cost is the cost of PET scanners. Our project proposes a radical vision to translate European breakthrough technological
advances in Time-of-Flight PET detection to a revolutionary, fully modular, cost-accessible flexible family of devices for
applications from the standard PET center to the surgery, epilepsy clinics, intensive care units and even emergency rooms and in
mobile units installed in vans. The proposed PetVision project aims to develop a simple pilot demonstrator, a modular panel PET device with a coincidence timing resolution of about 75 ps FWHM, close to the intrinsic timing limit of currently available PET scintillators. This resolution is several times better than the current gold standard of 214 ps FWHM achieved with the current clinical state-of-the-art device (Siemens Biograph Vision). With such excellent timing, the panel detectors can cover only a limited solid angle to reach the same sensitivity or improve the sensitivity in the case of a total-body imager. For the realization of the device, a package of breakthrough innovations in detector design, photo-sensor, and front-end electronics are planned. We expect that the proposed device will dramatically impact human health.

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

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(opens in new window) HORIZON-EIC-2022-PATHFINDEROPEN-01

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Coordinator

INSTITUT JOZEF STEFAN
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 832 183,00
Address
Jamova 39
1000 Ljubljana
Slovenia

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 832 183,00

Participants (5)

Partners (3)

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