STOP 2030: TOWARDS THE INTERRUPTION OF TRANSMISSION OF SOIL-TRANSMITTED HELMINTHS: PROMOTING IMPLEMENTATION OF RESEARCH RESULTS OF A FIXED-DOSE COMBINATION OF CO-FORMULATED IVERMECTIN AND ALBENDAZOLE

Información del proyecto

STOP2030

Identificador del acuerdo de subvención: 101103089

DOI

10.3030/101103089

Fecha de la firma de la CE 7 Marzo 2023

Fecha de inicio 1 Julio 2023

Fecha de finalización 30 Junio 2027

Financiado con arreglo a

• Health

Coste total

€ 5 046 435,75

Aportación de la UE

€ 3 553 502,25

Coordinado por

LABORATORIOS LICONSA SA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (9)

Communication Plan

Internal Communication plan to define the internal communication channels and tools to promote the exchange of ideas and the sharing of information among the Consortium's members.

Clinical data management plan (cDMP)

Description of the data management life cycle for the data to be collected, processed and/or generated by STOP2030 project

Registration number of clinical study

Trial registration in public access trial repositories

Clinical monitoring plan

Plan establishing the guidelines for conducting monitoring visits and timelines

Terms of reference for project committees

Define the different project Committees, scope, frequency and participant

Genomic protocol

Protocol for reporting on genomic data generation and submission to open access repositories, standardisation of code description and availability

Risk management record (Y1)

List of potential risk and mitigation plans to either avoid or minimize

Data analysis and interpretation

Analyse and interpretate data in collaboration with Consortium members

Formative study on Acceptability & Feasibility completed

Protocol for the formative study on acceptability and feasibility to be implemented in Ghana and Kenya

Websites, patent fillings, videos etc. (1)

Launched Project - WEBSITE

Project Website and as per good practices, all work packages leads will be listed.

Publicaciones

Peer reviewed articles (8)

Implications of global health funding patterns for implementation of a novel soil-transmitted helminth and lymphatic filariasis medicine: Ivermectin/albendazole fixed-dose combination

Autores: Israel Wuresah, Alan Brooks, Nikita Kubal, Marina Gold, Alejandro Krolewiecki, Julie Jacobson
Publicado en: PLOS Neglected Tropical Diseases, Edición 20, 2026, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014458

Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment

Autores: Javier Gandasegui, Berta Grau-Pujol, Valdemiro Novela, Osvaldo Muchisse, Maria Cambra-Pellejà, Anélsio Cossa, José Carlos Jamine, Charfudin Sacoor, Eric A.T. Brienen, Francesc Catala-Moll, Lisette van Lieshout, María Martínez-Valladares, Roger Paredes, José Muñoz, Stephen R. Doyle
Publicado en: International Journal for Parasitology: Drugs and Drug Resistance, Edición 26, 2024, ISSN 2211-3207
Editor: Elsevier BV
DOI: 10.1016/J.IJPDDR.2024.100570

Assessing the diagnostic value of qPCR for Trichuris trichiura: sub-analysis of a multi-country clinical trial to determine the efficacy of albendazole compared to an albendazole-ivermectin fixed dose combination

Autores: Pedro E. Fleitas, Michel Bengtson, Augusto Messa, Brian Bartilol, Woyneshet Gelaye, Stella Kepha, Javier Gandasegui, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, Alejandro Krolewiecki, Jose Muñoz, Martin Rono, Lisette van Lieshout
Publicado en: Frontiers in Parasitology, Edición 4, 2025, ISSN 2813-2424
Editor: Frontiers Media SA
DOI: 10.3389/FPARA.2025.1679294

Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis

Autores: Adriana Echazu, Daniela Bonanno, Pedro Emanuel Fleitas, Julie Jacobson, Gabriela Matamoros, Charles Mwandawiro, Wendemagegn Enbiale, Áuria de Jesus, Alan Brooks, Alejandro Javier Krolewiecki
Publicado en: PLOS Neglected Tropical Diseases, Edición 19, 2025, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0013059

Cost-effectiveness of soil-transmitted helminthiasis intervention programmes: A scoping review

Autores: Michael Odhiambo, Israel Wuresah, Geofrey Chepchieng, Nikita Kubal, Alejandro Krolewiecki, Charles Mwandawiro, Alan Brooks, Collins Okoyo
Publicado en: PLOS Neglected Tropical Diseases, Edición 20, 2026, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014317

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets

Autores: Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara SR Ajjampur, Roy M. Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R. Caro, David Chaima, Rubén O. Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L. Houlder, Moudachirou Ibikounlé, Timothy P. Jenkins, Khumbo Kalua, Eyrun F. Kjetland, Alejandro J. Krolewiecki, Bruno Levecke, Adrian JF Luty, Andrew S. MacDonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R. Odiere, Charfudin Sacoor, Judd L. Walson, Steven A. Williams, Stefan Witek-McManus, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61687-0

Comparison of multi-parallel quantitative real-time PCRs targeting different DNA regions and detecting soil-transmitted helminths in stool

Autores: Marina Papaiakovou, Rubén O. Cimino, Nils Pilotte, Julia Dunn, D. Timothy J. Littlewood, Steven A. Williams, Alejandro J. Krolewiecki, Rojelio Mejia
Publicado en: Parasites & Vectors, Edición 17, 2024, ISSN 1756-3305
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13071-024-06464-6

Individual-level analysis of the efficacy of albendazole and albendazole-ivermectin fixed-dose coformulation (FDC) against Trichuris trichiura and hookworms

Autores: Pedro E. Fleitas, Javier Gandasegui, Woyneshet Gelaye, Augusto Messa, Stella Kepha, Lisette van Lieshout, Jaime Algorta, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, José Muñoz, Alejandro Krolewiecki
Publicado en: Acta Tropica, Edición 269, 2025, ISSN 0001-706X
Editor: Elsevier BV
DOI: 10.1016/J.ACTATROPICA.2025.107742