STOP 2030: TOWARDS THE INTERRUPTION OF TRANSMISSION OF SOIL-TRANSMITTED HELMINTHS: PROMOTING IMPLEMENTATION OF RESEARCH RESULTS OF A FIXED-DOSE COMBINATION OF CO-FORMULATED IVERMECTIN AND ALBENDAZOLE

Informations projet

STOP2030

N° de convention de subvention: 101103089

DOI

10.3030/101103089

Date de signature de la CE 7 Mars 2023

Date de début 1 Juillet 2023

Date de fin 30 Juin 2027

Financé au titre de

• Health

Coût total

€ 5 046 435,75

Contribution de l’UE

€ 3 553 502,25

Coordonné par

LABORATORIOS LICONSA SA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (9)

Communication Plan

Internal Communication plan to define the internal communication channels and tools to promote the exchange of ideas and the sharing of information among the Consortium's members.

Clinical data management plan (cDMP)

Description of the data management life cycle for the data to be collected, processed and/or generated by STOP2030 project

Registration number of clinical study

Trial registration in public access trial repositories

Clinical monitoring plan

Plan establishing the guidelines for conducting monitoring visits and timelines

Terms of reference for project committees

Define the different project Committees, scope, frequency and participant

Genomic protocol

Protocol for reporting on genomic data generation and submission to open access repositories, standardisation of code description and availability

Risk management record (Y1)

List of potential risk and mitigation plans to either avoid or minimize

Data analysis and interpretation

Analyse and interpretate data in collaboration with Consortium members

Formative study on Acceptability & Feasibility completed

Protocol for the formative study on acceptability and feasibility to be implemented in Ghana and Kenya

Websites, patent fillings, videos etc. (1)

Launched Project - WEBSITE

Project Website and as per good practices, all work packages leads will be listed.

Publications

Peer reviewed articles (8)

Implications of global health funding patterns for implementation of a novel soil-transmitted helminth and lymphatic filariasis medicine: Ivermectin/albendazole fixed-dose combination

Auteurs: Israel Wuresah, Alan Brooks, Nikita Kubal, Marina Gold, Alejandro Krolewiecki, Julie Jacobson
Publié dans: PLOS Neglected Tropical Diseases, Numéro 20, 2026, ISSN 1935-2735
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014458

Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment

Auteurs: Javier Gandasegui, Berta Grau-Pujol, Valdemiro Novela, Osvaldo Muchisse, Maria Cambra-Pellejà, Anélsio Cossa, José Carlos Jamine, Charfudin Sacoor, Eric A.T. Brienen, Francesc Catala-Moll, Lisette van Lieshout, María Martínez-Valladares, Roger Paredes, José Muñoz, Stephen R. Doyle
Publié dans: International Journal for Parasitology: Drugs and Drug Resistance, Numéro 26, 2024, ISSN 2211-3207
Éditeur: Elsevier BV
DOI: 10.1016/J.IJPDDR.2024.100570

Assessing the diagnostic value of qPCR for Trichuris trichiura: sub-analysis of a multi-country clinical trial to determine the efficacy of albendazole compared to an albendazole-ivermectin fixed dose combination

Auteurs: Pedro E. Fleitas, Michel Bengtson, Augusto Messa, Brian Bartilol, Woyneshet Gelaye, Stella Kepha, Javier Gandasegui, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, Alejandro Krolewiecki, Jose Muñoz, Martin Rono, Lisette van Lieshout
Publié dans: Frontiers in Parasitology, Numéro 4, 2025, ISSN 2813-2424
Éditeur: Frontiers Media SA
DOI: 10.3389/FPARA.2025.1679294

Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis

Auteurs: Adriana Echazu, Daniela Bonanno, Pedro Emanuel Fleitas, Julie Jacobson, Gabriela Matamoros, Charles Mwandawiro, Wendemagegn Enbiale, Áuria de Jesus, Alan Brooks, Alejandro Javier Krolewiecki
Publié dans: PLOS Neglected Tropical Diseases, Numéro 19, 2025, ISSN 1935-2735
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0013059

Cost-effectiveness of soil-transmitted helminthiasis intervention programmes: A scoping review

Auteurs: Michael Odhiambo, Israel Wuresah, Geofrey Chepchieng, Nikita Kubal, Alejandro Krolewiecki, Charles Mwandawiro, Alan Brooks, Collins Okoyo
Publié dans: PLOS Neglected Tropical Diseases, Numéro 20, 2026, ISSN 1935-2735
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014317

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets

Auteurs: Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara SR Ajjampur, Roy M. Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R. Caro, David Chaima, Rubén O. Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L. Houlder, Moudachirou Ibikounlé, Timothy P. Jenkins, Khumbo Kalua, Eyrun F. Kjetland, Alejandro J. Krolewiecki, Bruno Levecke, Adrian JF Luty, Andrew S. MacDonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R. Odiere, Charfudin Sacoor, Judd L. Walson, Steven A. Williams, Stefan Witek-McManus, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61687-0

Comparison of multi-parallel quantitative real-time PCRs targeting different DNA regions and detecting soil-transmitted helminths in stool

Auteurs: Marina Papaiakovou, Rubén O. Cimino, Nils Pilotte, Julia Dunn, D. Timothy J. Littlewood, Steven A. Williams, Alejandro J. Krolewiecki, Rojelio Mejia
Publié dans: Parasites & Vectors, Numéro 17, 2024, ISSN 1756-3305
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13071-024-06464-6

Individual-level analysis of the efficacy of albendazole and albendazole-ivermectin fixed-dose coformulation (FDC) against Trichuris trichiura and hookworms

Auteurs: Pedro E. Fleitas, Javier Gandasegui, Woyneshet Gelaye, Augusto Messa, Stella Kepha, Lisette van Lieshout, Jaime Algorta, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, José Muñoz, Alejandro Krolewiecki
Publié dans: Acta Tropica, Numéro 269, 2025, ISSN 0001-706X
Éditeur: Elsevier BV
DOI: 10.1016/J.ACTATROPICA.2025.107742