STOP 2030: TOWARDS THE INTERRUPTION OF TRANSMISSION OF SOIL-TRANSMITTED HELMINTHS: PROMOTING IMPLEMENTATION OF RESEARCH RESULTS OF A FIXED-DOSE COMBINATION OF CO-FORMULATED IVERMECTIN AND ALBENDAZOLE

Informazioni relative al progetto

STOP2030

ID dell’accordo di sovvenzione: 101103089

DOI

10.3030/101103089

Data della firma CE 7 Marzo 2023

Data di avvio 1 Luglio 2023

Data di completamento 30 Giugno 2027

Finanziato da

• Health

Costo totale

€ 5 046 435,75

Contributo UE

€ 3 553 502,25

Coordinato da

LABORATORIOS LICONSA SA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (9)

Communication Plan

Internal Communication plan to define the internal communication channels and tools to promote the exchange of ideas and the sharing of information among the Consortium's members.

Clinical data management plan (cDMP)

Description of the data management life cycle for the data to be collected, processed and/or generated by STOP2030 project

Registration number of clinical study

Trial registration in public access trial repositories

Clinical monitoring plan

Plan establishing the guidelines for conducting monitoring visits and timelines

Terms of reference for project committees

Define the different project Committees, scope, frequency and participant

Genomic protocol

Protocol for reporting on genomic data generation and submission to open access repositories, standardisation of code description and availability

Risk management record (Y1)

List of potential risk and mitigation plans to either avoid or minimize

Data analysis and interpretation

Analyse and interpretate data in collaboration with Consortium members

Formative study on Acceptability & Feasibility completed

Protocol for the formative study on acceptability and feasibility to be implemented in Ghana and Kenya

Websites, patent fillings, videos etc. (1)

Launched Project - WEBSITE

Project Website and as per good practices, all work packages leads will be listed.

Pubblicazioni

Peer reviewed articles (8)

Implications of global health funding patterns for implementation of a novel soil-transmitted helminth and lymphatic filariasis medicine: Ivermectin/albendazole fixed-dose combination

Autori: Israel Wuresah, Alan Brooks, Nikita Kubal, Marina Gold, Alejandro Krolewiecki, Julie Jacobson
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 20, 2026, ISSN 1935-2735
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014458

Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment

Autori: Javier Gandasegui, Berta Grau-Pujol, Valdemiro Novela, Osvaldo Muchisse, Maria Cambra-Pellejà, Anélsio Cossa, José Carlos Jamine, Charfudin Sacoor, Eric A.T. Brienen, Francesc Catala-Moll, Lisette van Lieshout, María Martínez-Valladares, Roger Paredes, José Muñoz, Stephen R. Doyle
Pubblicato in: International Journal for Parasitology: Drugs and Drug Resistance, Numero 26, 2024, ISSN 2211-3207
Editore: Elsevier BV
DOI: 10.1016/J.IJPDDR.2024.100570

Assessing the diagnostic value of qPCR for Trichuris trichiura: sub-analysis of a multi-country clinical trial to determine the efficacy of albendazole compared to an albendazole-ivermectin fixed dose combination

Autori: Pedro E. Fleitas, Michel Bengtson, Augusto Messa, Brian Bartilol, Woyneshet Gelaye, Stella Kepha, Javier Gandasegui, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, Alejandro Krolewiecki, Jose Muñoz, Martin Rono, Lisette van Lieshout
Pubblicato in: Frontiers in Parasitology, Numero 4, 2025, ISSN 2813-2424
Editore: Frontiers Media SA
DOI: 10.3389/FPARA.2025.1679294

Fixed-dose ivermectin for Mass Drug Administration: Is it time to leave the dose pole behind? Insights from an Individual Participant Data Meta-Analysis

Autori: Adriana Echazu, Daniela Bonanno, Pedro Emanuel Fleitas, Julie Jacobson, Gabriela Matamoros, Charles Mwandawiro, Wendemagegn Enbiale, Áuria de Jesus, Alan Brooks, Alejandro Javier Krolewiecki
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 19, 2025, ISSN 1935-2735
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0013059

Cost-effectiveness of soil-transmitted helminthiasis intervention programmes: A scoping review

Autori: Michael Odhiambo, Israel Wuresah, Geofrey Chepchieng, Nikita Kubal, Alejandro Krolewiecki, Charles Mwandawiro, Alan Brooks, Collins Okoyo
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 20, 2026, ISSN 1935-2735
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PNTD.0014317

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets

Autori: Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara SR Ajjampur, Roy M. Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R. Caro, David Chaima, Rubén O. Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L. Houlder, Moudachirou Ibikounlé, Timothy P. Jenkins, Khumbo Kalua, Eyrun F. Kjetland, Alejandro J. Krolewiecki, Bruno Levecke, Adrian JF Luty, Andrew S. MacDonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R. Odiere, Charfudin Sacoor, Judd L. Walson, Steven A. Williams, Stefan Witek-McManus, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61687-0

Comparison of multi-parallel quantitative real-time PCRs targeting different DNA regions and detecting soil-transmitted helminths in stool

Autori: Marina Papaiakovou, Rubén O. Cimino, Nils Pilotte, Julia Dunn, D. Timothy J. Littlewood, Steven A. Williams, Alejandro J. Krolewiecki, Rojelio Mejia
Pubblicato in: Parasites & Vectors, Numero 17, 2024, ISSN 1756-3305
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13071-024-06464-6

Individual-level analysis of the efficacy of albendazole and albendazole-ivermectin fixed-dose coformulation (FDC) against Trichuris trichiura and hookworms

Autori: Pedro E. Fleitas, Javier Gandasegui, Woyneshet Gelaye, Augusto Messa, Stella Kepha, Lisette van Lieshout, Jaime Algorta, Áuria de Jesus, Valdemiro Novela, Inácio Mandomando, Charles Mwandawiro, Wendemagegn Enbiale, José Muñoz, Alejandro Krolewiecki
Pubblicato in: Acta Tropica, Numero 269, 2025, ISSN 0001-706X
Editore: Elsevier BV
DOI: 10.1016/J.ACTATROPICA.2025.107742