Description du projet
Renforcer la capacité de la génomique à gérer les épidémies en Afrique
Les infections pathogènes constituent un défi important en Afrique, soulignant la nécessité d’améliorer le diagnostic, le suivi et la gestion clinique des épidémies actuelles et futures sur le continent. Le projet GenPath Africa, financé par l’UE, se consacre à la lutte contre les infections pathogènes en Afrique. Il entend renforcer les capacités en génomique et lutter contre le VIH-1 et la tuberculose résistants aux médicaments grâce à la médecine de précision. Il se propose également de faire appel à l’épidémiologie génomique pour éclairer les stratégies de santé publique. GenPath Africa utilisera des méthodes de pointe pour détecter de nouveaux agents pathogènes, assurera une formation en Afrique du Sud, transférera des technologies à l’Institut national de santé publique du Mozambique et établira des liens entre l’initiative de génomique des agents pathogènes d’Africa CDC (Africa PGI) et les installations publiques de génomique d’Afrique du Sud et du Kenya.
Objectif
The overall goal of GenPath Africa is to control pathogen infections in Africa. Our consortium of African and European investigators proposes to build on our collective experience in responding to SARS-CoV-2 to better diagnose, monitor and clinically manage current and future epidemics in Africa. We propose to expand genomics capacity to combat drug resistant HIV-1 and TB through precision medicine and by using genomic epidemiology to guide the public health response. GenPath Africa will also apply recent developments in wastewater and one health surveillance to detect emerging pathogens. Capacity development activities will include degree training in South Africa and the transfer of technology to the National Public Health Institute of Mozambique.
The consortium’s objectives will be achieved by connecting the specialized genomics facilities of the Africa CDC Pathogen Genomics Initiative (Africa PGI) in South Africa and Kenya with African national public health institutes to translate scientific advances into public health actions. Long-term collaborations with Germany and Belgium will be leveraged to help achieve these objectives and make precision medicine and precision public health a reality in southern and East Africa. The consortium will also contribute to the long-term capacity building objectives of Africa PGI by contributing to harmonising training resources and collaboration with existing networks to ensure that all data are of high quality and available in public databases.
GenPath Africa will advance the EDTCP3 work program by: i) providing researchers and public health professionals with skills in genomic epidemiology to better understand infectious disease epidemiology and drug resistance, ii) strengthening capability in southern and East Africa to rapidly respond to current and emerging epidemics, and iii) providing researchers with training to advance their scientific careers in Africa and establish themselves as scientific and public health leaders.
Champ scientifique
- natural sciencesbiological sciencesgenetics
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance
- medical and health scienceshealth sciencespersonalized medicine
Programme(s)
- HORIZON.2.1 - Health Main Programme
Régime de financement
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinateur
7600 Stellenbosch
Afrique du Sud