Descripción del proyecto
Mejorar la capacidad genómica para controlar epidemias en África
Las infecciones por microorganismos patógenos constituyen todo un reto en África, lo que pone de relieve la necesidad de mejorar el diagnóstico, el seguimiento y la gestión clínica de las epidemias actuales y futuras en la región. El proyecto GenPath Africa, financiado con fondos europeos, se centra en hacer frente a las infecciones por microorganismos patógenos en África. El objetivo es mejorar la capacidad genómica y combatir el VIH-1 y la tuberculosis farmacorresistentes mediante la medicina de precisión. Además, se pretende utilizar la epidemiología genómica para fundamentar las estrategias sanitarias. En GenPath Africa se emplearán metodologías punteras para detectar microorganismos patógenos emergentes, se impartirá formación en Sudáfrica, se transferirá tecnología al Instituto Nacional de Salud Pública de Mozambique y se establecerán conexiones entre la Iniciativa de Genómica de Patógenos de los Centros para el Control y la Prevención de Enfermedades de África (Africa PGI, por sus siglas en inglés) y las instalaciones públicas de genómica de Sudáfrica y Kenia.
Objetivo
The overall goal of GenPath Africa is to control pathogen infections in Africa. Our consortium of African and European investigators proposes to build on our collective experience in responding to SARS-CoV-2 to better diagnose, monitor and clinically manage current and future epidemics in Africa. We propose to expand genomics capacity to combat drug resistant HIV-1 and TB through precision medicine and by using genomic epidemiology to guide the public health response. GenPath Africa will also apply recent developments in wastewater and one health surveillance to detect emerging pathogens. Capacity development activities will include degree training in South Africa and the transfer of technology to the National Public Health Institute of Mozambique.
The consortium’s objectives will be achieved by connecting the specialized genomics facilities of the Africa CDC Pathogen Genomics Initiative (Africa PGI) in South Africa and Kenya with African national public health institutes to translate scientific advances into public health actions. Long-term collaborations with Germany and Belgium will be leveraged to help achieve these objectives and make precision medicine and precision public health a reality in southern and East Africa. The consortium will also contribute to the long-term capacity building objectives of Africa PGI by contributing to harmonising training resources and collaboration with existing networks to ensure that all data are of high quality and available in public databases.
GenPath Africa will advance the EDTCP3 work program by: i) providing researchers and public health professionals with skills in genomic epidemiology to better understand infectious disease epidemiology and drug resistance, ii) strengthening capability in southern and East Africa to rapidly respond to current and emerging epidemics, and iii) providing researchers with training to advance their scientific careers in Africa and establish themselves as scientific and public health leaders.
Ámbito científico
- natural sciencesbiological sciencesgenetics
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance
- medical and health scienceshealth sciencespersonalized medicine
Palabras clave
Programa(s)
- HORIZON.2.1 - Health Main Programme
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinador
7600 Stellenbosch
Sudáfrica