Descripción del proyecto
Transformar la vigilancia de las enfermedades en África
El azote implacable de la tuberculosis, el paludismo y las enfermedades infecciosas emergentes sigue amenazando la vida de las personas en África. El problema a la hora de combatir estas enfermedades radica en la insuficiente comprensión de su dinámica, la limitada capacidad genómica y la fragmentación del intercambio de datos en África. Teniendo esto en cuenta, en el proyecto PANGenS, financiado con fondos europeos, se pretende transformar el planteamiento africano del control de enfermedades a través de la epidemiología genómica. Su objetivo principal es dotar al continente de competencias punteras en genómica, gestión de datos y biobancos y, al mismo tiempo, favorecer un intercambio de datos eficiente. Con un arsenal de hipótesis, que incluyen la mejora de la vigilancia, mejores respuestas a los microorganismos patógenos emergentes y diagnósticos mejorados, PANGenS aspira a mejorar la vigilancia de las enfermedades, formar a la próxima generación de científicos africanos y fomentar colaboraciones científicas sólidas en África.
Objetivo
The main aim of the proposed project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa as to better understand disease etiology, dynamics of disease transmission, and evolution of drug-resistant pathogens. The study also aims to increase Africa's capacity in bioinformatics, genomics, genomics data management, biobanking, and promote data sharing. Our goal is to improve the health of Africans with innovations in disease surveillance, equip the next generation of African scientists with cutting edge skills and strengthening south-south research collaborations. We propose the following hypotheses:
1. Increased capacity in genomic epidemiology will enable more effective disease surveillance in Africa.
2. Increased capacity in biobanking and genomics data management and analysis in Africa will enhance regional surveillance of infectious diseases and encourage timely and effective responses to emerging pathogens.
3. Regional whole genome sequence-based surveillance will improve the detection of DR-TB and inform the development of more sensitive and specific rapid diagnostics for the detection and surveillance of DR-TB in Africa and elsewhere.
4. Regional genomic surveillance of malaria parasites will inform a pre-emptive detection of emerging DR parasites and measure the impact of programmatic interventions for a data driven decision making by policy makers.
5. Implementation of harmonized genomic data analysis tools will allow the creation of continent-wide surveillance networks able to identify cross-border spread of DR variants and emerging pathogens.
To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by establishing a collaborative framework that brings together all expertise to perform trainings and implementation in all relevant components ranging from wet lab to bioinformatics, and establish proof-of-concept studies for TB and malaria in in selected partner countries
Ámbito científico
- natural sciencescomputer and information sciencesdata science
- medical and health scienceshealth sciencesinfectious diseasesmalaria
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesclinical medicinepneumologytuberculosis
- natural sciencesbiological sciencesgeneticsgenomes
Palabras clave
Programa(s)
- HORIZON.2.1 - Health Main Programme
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinador
23845 Borstel
Alemania