Descripción del proyecto
Investigación clínica sobre la sepsis neonatal en el África subsahariana
Mejorar el tratamiento de las infecciones infantiles en el África subsahariana (ASS) es fundamental, sobre todo a tenor del aumento de la resistencia a los antimicrobianos. Este problema afecta sobremanera a los neonatos y niños hospitalizados con sepsis. En el proyecto SNIP-AFRICA, financiado con fondos europeos, se pretende crear una red de investigación clínica en el ASS para abordar la sepsis neonatal de forma integral. Sus objetivos incluyen la identificación de posibles tratamientos, la realización de estudios de intervención y la orientación clínica. Este proyecto aspira a revolucionar la investigación intervencionista sobre infecciones infantiles graves mediante el fomento de la colaboración con socios del Norte Global y del ASS, lo que mejorará las capacidades y conocimientos existentes.
Objetivo
SNIP-AFRICA aims to establish a clinical research network and architecture to implement adaptive platform trials in sub-Saharan Africa (SSA), responding to the urgent need for improved treatment of childhood infection in an era of increasing antimicrobial resistance (AMR).
SNIP-AFRICA focuses on the high-burden, high-impact group of inpatient neonates and infants with sepsis. This is a group especially affected by escalating rates of AMR in SSA healthcare facilities contributing to much slower than desirable improvements in neonatal mortality across SSA.
The project will address all aspects of APTs in neonatal sepsis from defining potential treatments of interest to translation into clinical guidance, and will deliver interventional studies in the two domains of neonatal dose confirmation and drug regimen selection. The network and architecture could be readily extended to include older children in hospital with infections with epidemic potential.
SNIP-AFRICA will achieve its aim by bringing together partners from the global North and SSA, including several with experience in designing and running adaptive platform trials and complex randomised controlled trials in SSA. The project therefore builds on existing expertise and capacity to enable an innovative response to the major threat to child health of AMR through a new architecture and extended network. The work plan includes Project Management, Coordination and Communication (WP1), Clinical and Microbiological Surveillance (WP2), Adaptive Platform Core Protocol and Governance (WP3), Pharmacokinetics for Adaptive Platform Trial (WP4), Complex Adaptive Drug Regimen Trial (WP5), Training and Capacity building for Adaptive Trials (WP6) and Stakeholder Engagement and Integration (WP7).
SNIP-AFRICA aims to trigger a paradigm shift in interventional research in severe childhood infection and to equip a network of SSA institutions and researchers to conduct innovative, efficient, targeted research in this area.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.2.1 - Health Main Programme
Convocatoria de propuestas
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HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinador
35127 Padova
Italia