A general bismuth-based platform for the catalytic construction of carbon–nitrogen bonds and beyond.

Informazioni relative al progetto

ClaN-Bi

ID dell’accordo di sovvenzione: 101105383

DOI

10.3030/101105383

Progetto chiuso

Data della firma CE 21 Marzo 2023

Data di avvio 1 Maggio 2023

Data di completamento 30 Aprile 2025

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 173 847,36

Coordinato da

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 1 - ClaN-Bi (A general bismuth-based platform for the catalytic construction of carbon–nitrogen bonds and beyond.)

Periodo di rendicontazione: 2023-05-01 al 2025-04-30

Sintesi del contesto e degli obiettivi generali del progetto

The creation of carbon-nitrogen (C-N) and carbon-carbon (C-C) bonds is a cornerstone of modern chemistry, enabling the synthesis of complex molecules used in medicines, agriculture, and materials. Top-selling drugs rely on C-N bonds to achieve their function, yet traditional methods to form these bonds use expensive and toxic metals like palladium, posing environmental and cost challenges. The ClaN-Bi project aimed to transform this landscape by harnessing bismuth, a non-toxic, as a sustainable catalyst for these critical reactions. Recent discoveries have shown that bismuth can mimic transition metals by cycling through different chemical states (Bi(I) to Bi(III) or Bi(III) to Bi(V)) and generate reactive radicals, offering new pathways for chemical synthesis. Within this project, we pursued two key objectives: 1) Develop new bismuth-based chemical processes, focusing on radical-generating steps and transition metal-like reactions to form C-N and C-C bonds; 2) Establish catalytic cycles using low-valent bismuth to create these bonds efficiently, providing a greener and cheaper alternative to conventional methods. By integrating radical and polar mechanisms, often aided by light-driven (photochemical) steps, the project sought to unlock bismuth’s untapped potential in catalysis.

Over the course of this action, we have demonstrated bismuth’s potential to catalyze innovative reactions, inspiring new research directions in chemistry. These advancements could lower production costs for medicines and agrochemicals, making them more accessible.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Within this project, we synthesized and studied new bismuth compounds to develop catalytic processes for forming C-N and C-C bonds. Using advanced analytical techniques, we explored how bismuth complexes generate carbon-centered radicals and cycle through redox states (Bi(I) to Bi(III)). A novel radical generation strategy enabled two major achievements in C-C bond formation: first, a bismuth-catalyzed method to add trifluoromethyl groups to molecules, a critical step in drug discovery; second, a bismuth-catalyzed process to form cyclopropane rings, essential building blocks for pharmaceuticals and agrochemicals. The knowledge gathered during the action is instrumental in promoting C-N and C-Het bond formation.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

The findings of this action open new avenues for main group elements in catalysis, challenging the reliance on traditional metals. To ensure further uptake, additional research is needed to optimize C-N bond formation and explore industrial applications. Support for commercialization, such as partnerships with pharmaceutical companies, intellectual property protection, and regulatory frameworks for bismuth-based catalysts, will be crucial. The project’s results, shared openly, lay a foundation for future innovations in green chemistry, with potential to impact global chemical production.

Bi-redox photocatalysis for organic synthesis