Objective
All living organisms emerge from a single cell, the zygote. In early embryo development of animals, the interplay of cell surface dynamics, polarity proteins and intracellular flows forms distinct polarity domains, which the cell uses to specify the fate of its daughter cells. A classical biological model to learn how animal cells polarise is the 1-mm long C. elegans roundworm. Establishment of cell polarity in the C. elegans zygote is well studied, yet the biophysical mechanisms controlling cell polarity beyond that stage remain largely unexplored. Biophysical experiments and Finite Element (FE) models could together elucidate this matter. However, FE models of multicellular morphogenesis, other than rare, rely on explicit surface descriptions. Explicit methods are not ideal to simulate cell polarity at the multicellular scale, because they can hardly deal simultaneously with 3D foamlike geometries, coupled surface-bulk physics and topology changes. Conversely, FE methods based on implicit surfaces have recently shown convincing potential to bypass this weakness. In this project, I will launch a new implicit-surface FE paradigm to simulate early embryo development and I will apply it to gain new insights on the patterning of C. elegans embryos. To this end, I will pioneer implicit-surface FE methods for coupled surface-bulk dynamics in foamlike geometries. The success of the project is ensured by joining leading expertise in implicit-surface FEs from myself, biophysics of morphogenesis from my supervisor, and patterning in C. elegans embryos from my external collaborator. I will be based at the Center for Interdisciplinary Research in Biology of the CNRS, located at Collge de France; a unique and ideal place to create new synergies between a FE researcher like me, biophysicists and cell biologists, as well as to grow and diversify my scientific and transferrable skills to become one of the few independent leaders in FEs for multicellular morphogenesis in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics topology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biophysics
- natural sciences mathematics pure mathematics geometry
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.