Nanopore sequencing of cell-free DNA for the sensitive detection, molecular profiling and monitoring of childhood cancers

Project Information

PaedsSeq

Grant agreement ID: 101106070

DOI

10.3030/101106070

Project closed

EC signature date 3 April 2023

Start date 1 June 2023

End date 31 May 2025

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 220 908,48

Coordinated by

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Communication, Dissemination and Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the action It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Publications

Peer reviewed articles (4)

SAVANA: reliable analysis of somatic structural variants and copy number aberrations using long-read sequencing

Author(s): Hillary Elrick, Carolin M. Sauer, Jose Espejo Valle-Inclan, Katherine Trevers, Melanie Tanguy, Sonia Zumalave, Solange De Noon, Francesc Muyas, Rita Cascão, Angela Afonso, Alistair G. Rust, Fernanda Amary, Roberto Tirabosco, Adam Giess, Timothy Freeman, Alona Sosinsky, Katherine Piculell, David T. Miller, Claudia C. Faria, Greg Elgar, Adrienne M. Flanagan, Isidro Cortes-Ciriano
Published in: Nature Methods, Issue 22, 2025, ISSN 1548-7091
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41592-025-02708-0

Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states

Author(s): Sally L. George, Claire Lynn, Reda Stankunaite, Debbie Hughes, Carolin M. Sauer, Jane Chalker, Saira Waqar Ahmed, Minou Oostveen, Paula Z. Proszek, Lina Yuan, Ridwan Shaikh, Sabri Jamal, Ama Brew, Jennifer Tall, Tony Rogers, Steven C. Clifford, Josef Vormoor, Janet M. Shipley, Deborah A. Tweddle, Chris Jones, Courtney Willis, G.A. Amos Burke, Aditi Vedi, Lisa Howell, Robert Johnston, Helen Rees, Madeleine Adams, Angela Jesudason, Milind Ronghe, Martin Elliott, Emma Ross, Guy Makin, Quentin Campbell-Hewson, Richard G. Grundy, Jennifer Turnbull, Shaun Wilson, Victoria Lee, Juliet C. Gray, Sara Stoneham, Susanne A. Gatz, Lynley V. Marshall, Paola Angelini, John Anderson, George D. Cresswell, Trevor A. Graham, Bissan Al-Lazikani, Isidro Cortes-Ciriano, Pamela Kearns, J. Ciaran Hutchinson, Darren Hargrave, Thomas S. Jacques, Michael Hubank, Andrea Sottoriva, Louis Chesler
Published in: Cancer Discovery, 2024, ISSN 2159-8274
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2159-8290.CD-24-0916

SAVANA: reliable analysis of somatic structural variants and copy number aberrations in clinical samples using long-read sequencing

Author(s): Hillary Elrick; Carolin M Sauer; Jose Espejo Valle-Inclan; Katherine Trevers; Melanie Tanguy; Sonia Zumalave; Solange De Noon; Francesc Muyas; Rita Cascao; Angela Afonso; Fernanda Amary; Roberto Tirabosco; Adam Giess; Timothy Freeman; Alona Sosinsky; Katherine Piculell; David T Miller; Claudia C Faria; Greg Elgar; Adrienne M Flanagan; Isidro Cortes-Ciriano
Published in: Crossref, 2024, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.21203/RS.3.RS-4870639/V1

Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution

Author(s): Jose Espejo Valle-Inclan, Solange De Noon, Katherine Trevers, Hillary Elrick, Ianthe A.E.M. van Belzen, Sonia Zumalave, Carolin M. Sauer, Mélanie Tanguy, Thomas Butters, Francesc Muyas, Alistair G. Rust, Fernanda Amary, Roberto Tirabosco, Adam Giess, Alona Sosinsky, Greg Elgar, Adrienne M. Flanagan, Isidro Cortés-Ciriano
Published in: Cell, 2025, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/j.cell.2024.12.005