Expand Flow – Accessing new chemical space via a combined flash- and photochemical flow chemistry approach for the functionalisation and ring expansion of heterocycles

Project Information

Expand Flow

Grant agreement ID: 101106497

DOI

10.3030/101106497

Project closed

EC signature date 30 March 2023

Start date 16 October 2023

End date 15 October 2025

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 172 750,08

Coordinated by

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved.

Publications

Peer reviewed articles (9)

Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions

Author(s): Francesco Soddu, Iktedar Mahdi, Maria Chiara Cabua, Francesco Secci, Philipp Natho, Riccardo Tassoni, Paolo Dambruoso, Ernesto Mesto, Marco Colella, Renzo Luisi
Published in: Organic Letters, Issue 27, 2025, ISSN 1523-7060
Publisher: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.15542591

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

Author(s): Francesco Pasca, Yuri Gelato, Michael Andresini, Defne Serbetci, Philipp Natho, Giuseppe Romanazzi, Leonardo Degennaro, Marco Colella, Renzo Luisi
Published in: JACS Au, Issue 5, 2025, ISSN 2691-3704
Publisher: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.14441184

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Author(s): Michael Andresini, Laura Marraffa, Defne Şerbetçi, Philipp Natho, Marco Colella, Leonardo Degennaro, Renzo Luisi
Published in: Advanced Synthesis & Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.5281/ZENODO.13957138

Azabicyclo[1.1.0]butyl‐Substituted Sulfonimidoyl Fluoride: Electrophilic Hub Bridging Late‐Stage Azetidine Incorporation with Sufex Chemistry

Author(s): Defne Serbetci, Philipp Natho, Ernesto Mesto, Emanuela Schingaro, Marco Colella, Renzo Luisi
Published in: Advanced Synthesis & Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.5281/ZENODO.17257058

Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C−H Functionalization of 3‐Iodooxetane for the Synthesis of 1,5‐Dioxaspiro[2.3]hexanes

Author(s): Philipp Natho, Marco Colella, Annarita Vicenti, Giuseppe Romanazzi, Faizan Ullah, Nadeem S. Sheikh, Andrew J. P. White, Francesco Pasca, Renzo Luisi
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: Wiley
DOI: 10.5281/ZENODO.14754638

1‐Oxa‐2,6‐Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow‐Assisted Preparation and Derivatisation by Strain‐Release of Azabicyclo[1.1.0]butanes

Author(s): Elena Graziano, Philipp Natho, Michael Andresini, Fabrizio Mastrolorito, Iktedar Mahdi, Ernesto Mesto, Marco Colella, Leonardo Degennaro, Orazio Nicolotti, Renzo Luisi
Published in: Advanced Synthesis & Catalysis, Issue 366, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.5281/ZENODO.13365887

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines

Author(s): Yuri Gelato, Laura Marraffa, Francesco Pasca, Philipp Natho, Giuseppe Romanazzi, Arianna Tota, Marco Colella, Renzo Luisi
Published in: Journal of the American Chemical Society, Issue 147, 2025, ISSN 0002-7863
Publisher: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.17257145

Towards greener-by-design fine chemicals. Part 1: synthetic frontiers

Author(s): Theodore A. Gazis, Jonas Wuyts, Areti Moutsiou, Giulio Volpin, Mark J. Ford, Rodolfo I. Teixeira, Katherine M. P. Wheelhouse, Philipp Natho, Polona Žnidaršič-Plazl, Sonja Jost, Renzo Luisi, Brahim Benyahia, Bert U. W. Maes, Gianvito Vilé
Published in: Chemical Society Reviews, 2025, ISSN 0306-0012
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CS00929D

Flow chemistry as green technology for the genesis and use of organometallic reagents in the synthesis of key building blocks and APIs – An update

Author(s): Philipp Natho, Renzo Luisi
Published in: Tetrahedron Green Chem, Issue 2, 2025, ISSN 2773-2231
Publisher: Elsevier BV
DOI: 10.1016/J.TGCHEM.2023.100015