Bacterial Methionine Oxidation Repair and Aging

Informazioni relative al progetto

MOR-AGE

ID dell’accordo di sovvenzione: 101106503

DOI

10.3030/101106503

Progetto chiuso

Data della firma CE 22 Marzo 2023

Data di avvio 1 Maggio 2023

Data di completamento 30 Aprile 2025

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 211 754,88

Coordinato da

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Periodic Reporting for period 1 - MOR-AGE (Bacterial Methionine Oxidation Repair and Aging)

Periodo di rendicontazione: 2023-05-01 al 2025-04-30

Sintesi del contesto e degli obiettivi generali del progetto

Cells are constantly exposed to oxidative stress, which can damage essential molecules and affect their survival. Among the molecules targeted, proteins are particularly vulnerable. The MOR-AGE project aimed to better understand how bacteria repair oxidative damage in proteins, and how this process influences their capacity to cope with stress and age over time.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

During the project, advanced microscopy and genetic tools were developed to observe in real time how bacteria respond to oxidative stress. These tools made it possible to measure how protein repair mechanisms are activated and how they vary from one cell to another. The project also explored how these processes affect bacterial growth and survival under challenging conditions.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

The project produced new tools and experimental approaches to study protein oxidation and its physiological consequences at the single-cell level. These results go beyond the current state of the art by offering new ways to study how cells adapt to their environment and manage internal damage.

Single-cell imaging of E. coli under oxidative attacks