Bacterial Methionine Oxidation Repair and Aging

Información del proyecto

MOR-AGE

Identificador del acuerdo de subvención: 101106503

DOI

10.3030/101106503

Proyecto cerrado

Fecha de la firma de la CE 22 Marzo 2023

Fecha de inicio 1 Mayo 2023

Fecha de finalización 30 Abril 2025

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 211 754,88

Coordinado por

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Periodic Reporting for period 1 - MOR-AGE (Bacterial Methionine Oxidation Repair and Aging)

Período documentado: 2023-05-01 hasta 2025-04-30

Resumen del contexto y de los objetivos generales del proyecto

Cells are constantly exposed to oxidative stress, which can damage essential molecules and affect their survival. Among the molecules targeted, proteins are particularly vulnerable. The MOR-AGE project aimed to better understand how bacteria repair oxidative damage in proteins, and how this process influences their capacity to cope with stress and age over time.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

During the project, advanced microscopy and genetic tools were developed to observe in real time how bacteria respond to oxidative stress. These tools made it possible to measure how protein repair mechanisms are activated and how they vary from one cell to another. The project also explored how these processes affect bacterial growth and survival under challenging conditions.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

The project produced new tools and experimental approaches to study protein oxidation and its physiological consequences at the single-cell level. These results go beyond the current state of the art by offering new ways to study how cells adapt to their environment and manage internal damage.

Single-cell imaging of E. coli under oxidative attacks