Projektbeschreibung
Bakteriophagen und Antibiotikaresistenz genauer im Blick
Antibiotikaresistenzen können aus Umweltquellen wie Boden, Wasser und Lebensmitteln hervorgehen, denn hier werden die Bakterien Antibiotika oder antimikrobiellen Wirkstoffen ausgesetzt. Mit Unterstützung der Marie-Skłodowska-Curie-Maßnahmen werden im Rahmen des Projekts PHASTER das Vorhandensein, die Vielfalt und die Häufigkeit von Bakteriophagen in der Umwelt erkundet, um jene Mechanismen und Faktoren zu verstehen, die Antibiotikaresistenzen fördern. Dies erfolgt zur rechten Zeit, da jüngste Studien darauf hindeuten, dass im klinischen Bereich entdeckte Antibiotikaresistenzen aus Umweltquellen stammen könnten. PHASTER wird insbesondere die Quellen von Antibiotikaresistenzgenen, ihre Verteilung in der Umwelt und die Auswirkungen anthropogener Einflüsse auf ihre Verbreitung untersuchen. Es werden metagenomische und bioinformatische Ansätze zum Einsatz kommen und Mesokosmenexperimente durchgeführt. Die Ergebnisse des Projekts werden in Strategien für die öffentliche Gesundheit einfließen.
Ziel
Although antibiotic resistance is a major and growing public health concern, surveillance for the expansion of this phenomenon in environmental settings has not been fully explored. However, recent studies suggest that antibiotic resistance found in clinical settings may emerge from environmental sources. In fact, the environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations, which may contribute to the emergence and spread of antibiotic resistance. It is therefore necessary to understand the mechanisms and factors that promote antibiotic resistance. The PHASTER project aims at exploring the presence, diversity, and abundance of bacteriophages in the environment. Particular points of interest will be the study of bacteriophages that lead to the mobilization of antibiotic resistance genes (ARGs) and their interaction with antibiotic compounds, even at extremely low concentrations, similar to those found in some aquatic environments. Mesocosm experiments will also be conducted to examine how bacterial communities respond to the presence of bacteriophages harbouring ARGs under stressful conditions, such as exposure to antibiotics. In order to reach these goals, a combination of metagenomics and bioinformatics approaches will be used to investigate the sources of ARGs, their environmental distribution and how anthropogenic inputs affect their spread. A better understanding of the mechanisms and factors that contribute to antibiotic resistance will permit the implementation of appropriate public health strategies, policies, and mitigation programs. Special attention will also be devoted to dissemination so that stakeholders and policy makers can benefit from PHASTER.
Wissenschaftliches Gebiet
- medical and health scienceshealth sciencespublic health
- engineering and technologyenvironmental engineeringwater treatment processeswastewater treatment processes
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandryanimal feed
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
MSCA-PF - MSCA-PFKoordinator
17003 Girona
Spanien