Obiettivo
Orthopedic implant-associated biofilm infections represent a major public health and socioeconomic burden due the intrinsic tolerance of biofilms that behave as protective and immobile scaffolds to conventional antibiotics and immune system. Further, their long-term and repeated antibiotic treatments lead to an increased potential of antibiotic resistance development. Here, this interdisciplinary proposed project integrates innovative aspects of surface chemistry, 3D morphological characterization of coated implants, and precision engineering with attributes for production of much needed biofilm-targeting nanostructural implant coatings. It also considers the urgent societal needs for introducing an effective, flexible, and universal approach in orthopedic implant patterning and functionalization for combatting and preventing implant-associated biofilms. This core approach is based on controlled patterning with inverse non-lamellar lyotropic liquid crystalline phases having unique nanostructural versatility through prior precision priming of new 3D porous implant surfaces with tailor-made coating method, and their thorough characterization by using different modalities including GISAXS, neutron reflection, high-resolution X-ray photoelectron spectroscopy, and X-ray micro-computed tomography. This is in combination with in vitro profiling on model implant-associated biofilm infections. The project provides an environment with independent research activities for building my professional skills in a research topic at the interface of nanoscience, surface chemistry, and experimental medicine. In addition to training at different synchrotron facilities, my research career will be certainly advanced owing to the gained experience with state-of-art biophysical tools and supervision of Master students.
Campo scientifico
- medical and health sciencesbasic medicineimmunology
- engineering and technologymaterials engineeringcoating and films
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesmedical biotechnologyimplants
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinatore
1165 Kobenhavn
Danimarca