Modulation of complex lipids to promote healthy aging

Project Information

LipidAge

Grant agreement ID: 101108082

DOI

10.3030/101108082

Project closed

EC signature date 3 April 2023

Start date 1 August 2023

End date 31 December 2025

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 203 464,32

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Communication, Dissemination & Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the action It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Publications

Peer reviewed articles (11)

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Author(s): van der Rijt, Sanne; Molenaars, Marte; Kamble, Rashmi; Li, Weisha; Schomakers, Bauke V.; Dane, Adrie D.; Denis, Simone W.; van Weeghel, Michel; Vaz, Frédéric M.; Tammaro, Alessandra; Janssens, Georges E.; Gao, Arwen W.; Houtkooper, Riekelt H.
Published in: iScience, 2025, ISSN 2589-0042
Publisher: Elsvier
DOI: 10.1016/J.ISCI.2025.112880

Systems genetics of metabolic health in the BXD mouse genetic reference population

Author(s): Xiaoxu Li, Jean-David Morel, Jonathan Sulc, Alessia De Masi, Amélia Lalou, Giorgia Benegiamo, Johanne Poisson, Yasmine Liu, Giacomo V.G. Von Alvensleben, Arwen W. Gao, Maroun Bou Sleiman, Johan Auwerx
Published in: Cell Systems, Issue 15, 2024, ISSN 2405-4712
Publisher: Elsevier BV
DOI: 10.1016/J.CELS.2024.05.006

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Author(s): Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Published in: Cell Reports, Issue 43, 2026, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2024.114836

Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

Author(s): Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Published in: iScience, Issue 27, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2024.109949

Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

Author(s): Iman Man Hu, Marte Molenaars, Yorrick R. J. Jaspers, Bauke V. Schomakers, Michel van Weeghel, Amber Bakker, Melanie Modder, Joseph P. Dewulf, Guido T. Bommer, Arwen W. Gao, Georges E. Janssens, Riekelt H. Houtkooper
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61433-6

Plasma triacylglycerol length and saturation level mark healthy aging groups in humans

Author(s): Weisha Li, Bauke V. Schomakers, Michel van Weeghel, Lotte Grevendonk, Frédéric M. Vaz, Gajja S. Salomons, Patrick Schrauwen, Joris Hoeks, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Published in: GeroScience, Issue 47, 2025, ISSN 2509-2723
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11357-024-01453-0

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

Author(s): Gabriele Civiletto, Dario Brunetti, Giulia Lizzo, Kamila Muller, Guillaume E. Jacot, Ioanna Daskalaki, Federico Sizzano, Minji Huh, Ivano Di Meo, Maria Nicol Colombo, José L. Sanchez-Garcia, Bertrand J. Bétrisey, Alix Zollinger, Patricia Lino, Christopher Neal, Anne-Laure Egesipe, Joy Richard, Myriam Chimen, Aurélie Hermant, Benjamin Brinon, Lorane Texari, Sylviane Metairon, Mohammed Adnan Qureshi, Dhaval S. Patel, Siva A. Vanapalli, Marco Malavolta, Arwen W. Gao, Amelia Lalou, Mauro Provinciali, Fiorenza Orlando, Valeria Tiranti, Robert T. Brooke, Steve Horvath, Johan Auwerx, Jerome N. Feige, Philipp Gut
Published in: Nature Aging, Issue 5, 2025, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43587-025-00957-4

Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in C. elegans

Author(s): Iman Man Hu, Ana Serna, Stacia Everts, Lale Güngördü, Bauke V. Schomakers, Ellen A. A. Nollen, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Published in: GeroScience, Issue 47, 2025, ISSN 2509-2723
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11357-025-01599-5

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Author(s): Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx
Published in: Cell Discovery, Issue 9, 2023, ISSN 2056-5968
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41421-023-00589-1

A lysosomal surveillance response to stress extends healthspan

Author(s): Terytty Yang Li, Arwen W. Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Raya B. Liu, Wenzheng Wang, Ang Zhou, Tong-jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H. Houtkooper, Johan Auwerx
Published in: Nature Cell Biology, Issue 27, 2025, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41556-025-01693-Y

Data Management Plan

Published in: iScience, 2025, ISSN 2589-0042
Publisher: Cell
DOI: 10.1016/J.ISCI.2025.112880