Modulation of complex lipids to promote healthy aging

Información del proyecto

LipidAge

Identificador del acuerdo de subvención: 101108082

DOI

10.3030/101108082

Proyecto cerrado

Fecha de la firma de la CE 3 Abril 2023

Fecha de inicio 1 Agosto 2023

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 203 464,32

Coordinado por

STICHTING AMSTERDAM UMC
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Communication, Dissemination & Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the action It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Publicaciones

Peer reviewed articles (11)

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Autores: van der Rijt, Sanne; Molenaars, Marte; Kamble, Rashmi; Li, Weisha; Schomakers, Bauke V.; Dane, Adrie D.; Denis, Simone W.; van Weeghel, Michel; Vaz, Frédéric M.; Tammaro, Alessandra; Janssens, Georges E.; Gao, Arwen W.; Houtkooper, Riekelt H.
Publicado en: iScience, 2025, ISSN 2589-0042
Editor: Elsvier
DOI: 10.1016/J.ISCI.2025.112880

Systems genetics of metabolic health in the BXD mouse genetic reference population

Autores: Xiaoxu Li, Jean-David Morel, Jonathan Sulc, Alessia De Masi, Amélia Lalou, Giorgia Benegiamo, Johanne Poisson, Yasmine Liu, Giacomo V.G. Von Alvensleben, Arwen W. Gao, Maroun Bou Sleiman, Johan Auwerx
Publicado en: Cell Systems, Edición 15, 2024, ISSN 2405-4712
Editor: Elsevier BV
DOI: 10.1016/J.CELS.2024.05.006

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Autores: Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publicado en: Cell Reports, Edición 43, 2026, ISSN 2211-1247
Editor: Elsevier BV
DOI: 10.1016/J.CELREP.2024.114836

Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

Autores: Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Publicado en: iScience, Edición 27, 2025, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/J.ISCI.2024.109949

Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

Autores: Iman Man Hu, Marte Molenaars, Yorrick R. J. Jaspers, Bauke V. Schomakers, Michel van Weeghel, Amber Bakker, Melanie Modder, Joseph P. Dewulf, Guido T. Bommer, Arwen W. Gao, Georges E. Janssens, Riekelt H. Houtkooper
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61433-6

Plasma triacylglycerol length and saturation level mark healthy aging groups in humans

Autores: Weisha Li, Bauke V. Schomakers, Michel van Weeghel, Lotte Grevendonk, Frédéric M. Vaz, Gajja S. Salomons, Patrick Schrauwen, Joris Hoeks, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Publicado en: GeroScience, Edición 47, 2025, ISSN 2509-2723
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S11357-024-01453-0

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

Autores: Gabriele Civiletto, Dario Brunetti, Giulia Lizzo, Kamila Muller, Guillaume E. Jacot, Ioanna Daskalaki, Federico Sizzano, Minji Huh, Ivano Di Meo, Maria Nicol Colombo, José L. Sanchez-Garcia, Bertrand J. Bétrisey, Alix Zollinger, Patricia Lino, Christopher Neal, Anne-Laure Egesipe, Joy Richard, Myriam Chimen, Aurélie Hermant, Benjamin Brinon, Lorane Texari, Sylviane Metairon, Mohammed Adnan Qureshi, Dhaval S. Patel, Siva A. Vanapalli, Marco Malavolta, Arwen W. Gao, Amelia Lalou, Mauro Provinciali, Fiorenza Orlando, Valeria Tiranti, Robert T. Brooke, Steve Horvath, Johan Auwerx, Jerome N. Feige, Philipp Gut
Publicado en: Nature Aging, Edición 5, 2025, ISSN 2662-8465
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43587-025-00957-4

Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in C. elegans

Autores: Iman Man Hu, Ana Serna, Stacia Everts, Lale Güngördü, Bauke V. Schomakers, Ellen A. A. Nollen, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Publicado en: GeroScience, Edición 47, 2025, ISSN 2509-2723
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S11357-025-01599-5

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Autores: Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx
Publicado en: Cell Discovery, Edición 9, 2023, ISSN 2056-5968
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41421-023-00589-1

A lysosomal surveillance response to stress extends healthspan

Autores: Terytty Yang Li, Arwen W. Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Raya B. Liu, Wenzheng Wang, Ang Zhou, Tong-jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H. Houtkooper, Johan Auwerx
Publicado en: Nature Cell Biology, Edición 27, 2025, ISSN 1465-7392
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41556-025-01693-Y

Data Management Plan

Publicado en: iScience, 2025, ISSN 2589-0042
Editor: Cell
DOI: 10.1016/J.ISCI.2025.112880