Modulation of complex lipids to promote healthy aging

Informazioni relative al progetto

LipidAge

ID dell’accordo di sovvenzione: 101108082

DOI

10.3030/101108082

Progetto chiuso

Data della firma CE 3 Aprile 2023

Data di avvio 1 Agosto 2023

Data di completamento 31 Dicembre 2025

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 203 464,32

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Communication, Dissemination & Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the action It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Pubblicazioni

Peer reviewed articles (11)

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes

Autori: van der Rijt, Sanne; Molenaars, Marte; Kamble, Rashmi; Li, Weisha; Schomakers, Bauke V.; Dane, Adrie D.; Denis, Simone W.; van Weeghel, Michel; Vaz, Frédéric M.; Tammaro, Alessandra; Janssens, Georges E.; Gao, Arwen W.; Houtkooper, Riekelt H.
Pubblicato in: iScience, 2025, ISSN 2589-0042
Editore: Elsvier
DOI: 10.1016/J.ISCI.2025.112880

Systems genetics of metabolic health in the BXD mouse genetic reference population

Autori: Xiaoxu Li, Jean-David Morel, Jonathan Sulc, Alessia De Masi, Amélia Lalou, Giorgia Benegiamo, Johanne Poisson, Yasmine Liu, Giacomo V.G. Von Alvensleben, Arwen W. Gao, Maroun Bou Sleiman, Johan Auwerx
Pubblicato in: Cell Systems, Numero 15, 2024, ISSN 2405-4712
Editore: Elsevier BV
DOI: 10.1016/J.CELS.2024.05.006

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Autori: Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Pubblicato in: Cell Reports, Numero 43, 2026, ISSN 2211-1247
Editore: Elsevier BV
DOI: 10.1016/J.CELREP.2024.114836

Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

Autori: Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Pubblicato in: iScience, Numero 27, 2025, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2024.109949

Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

Autori: Iman Man Hu, Marte Molenaars, Yorrick R. J. Jaspers, Bauke V. Schomakers, Michel van Weeghel, Amber Bakker, Melanie Modder, Joseph P. Dewulf, Guido T. Bommer, Arwen W. Gao, Georges E. Janssens, Riekelt H. Houtkooper
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61433-6

Plasma triacylglycerol length and saturation level mark healthy aging groups in humans

Autori: Weisha Li, Bauke V. Schomakers, Michel van Weeghel, Lotte Grevendonk, Frédéric M. Vaz, Gajja S. Salomons, Patrick Schrauwen, Joris Hoeks, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Pubblicato in: GeroScience, Numero 47, 2025, ISSN 2509-2723
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S11357-024-01453-0

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

Autori: Gabriele Civiletto, Dario Brunetti, Giulia Lizzo, Kamila Muller, Guillaume E. Jacot, Ioanna Daskalaki, Federico Sizzano, Minji Huh, Ivano Di Meo, Maria Nicol Colombo, José L. Sanchez-Garcia, Bertrand J. Bétrisey, Alix Zollinger, Patricia Lino, Christopher Neal, Anne-Laure Egesipe, Joy Richard, Myriam Chimen, Aurélie Hermant, Benjamin Brinon, Lorane Texari, Sylviane Metairon, Mohammed Adnan Qureshi, Dhaval S. Patel, Siva A. Vanapalli, Marco Malavolta, Arwen W. Gao, Amelia Lalou, Mauro Provinciali, Fiorenza Orlando, Valeria Tiranti, Robert T. Brooke, Steve Horvath, Johan Auwerx, Jerome N. Feige, Philipp Gut
Pubblicato in: Nature Aging, Numero 5, 2025, ISSN 2662-8465
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43587-025-00957-4

Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in C. elegans

Autori: Iman Man Hu, Ana Serna, Stacia Everts, Lale Güngördü, Bauke V. Schomakers, Ellen A. A. Nollen, Arwen W. Gao, Riekelt H. Houtkooper, Georges E. Janssens
Pubblicato in: GeroScience, Numero 47, 2025, ISSN 2509-2723
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S11357-025-01599-5

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Autori: Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx
Pubblicato in: Cell Discovery, Numero 9, 2023, ISSN 2056-5968
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41421-023-00589-1

A lysosomal surveillance response to stress extends healthspan

Autori: Terytty Yang Li, Arwen W. Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Raya B. Liu, Wenzheng Wang, Ang Zhou, Tong-jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H. Houtkooper, Johan Auwerx
Pubblicato in: Nature Cell Biology, Numero 27, 2025, ISSN 1465-7392
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41556-025-01693-Y

Data Management Plan

Pubblicato in: iScience, 2025, ISSN 2589-0042
Editore: Cell
DOI: 10.1016/J.ISCI.2025.112880